Doctor insights on:
Hepatocellular Carcinoma Pathology
Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Stage-Dependent: Breast cancers are staged based upon the size of the cancer, lymph node or distant organ involvement, and unique molecular features of the tumor. Published rates of 5-yr survival (http://www.Cancer.Org/cancer/breastcancer/detailedguide/breast-cancer-survival-by-stage) vary quite a bit based on these variables, between 15%-93%. The type of cancer (ductal, lobular, etc) doesn't impact survival. ...Read more
Genetic component?: There could be genetic component to a squamous cell cancer, although the exact implications on treatment aren't known. Obviously if there is a strong family history of cancers, or if it strikes someone who is young and/or a non smoker/drinker i would suspect a strong genetic contribution. Without more details, it is hard to say with any certainty. ...Read moreSee 1 more doctor answer
Viral insertion: DCIS is the earliest phase of transformation to malignancy developing in the ductal system before invasion into parenchyma has occurred. It is defined on mammo by clustered microcalcification. In general the long terminal repeat of the MMTV viral genome enters the ductal cell to initiate transformation. with time the cells become aggressive and invade basement membrane helped by the EBV virus ...Read more
Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?
Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more
No: The description you provided is not consistent with a diagnosis of carcinoma. It is more consistent with changes due to chronic inflammation. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
Not yet: Hyperplasia is a lot of benign cells that are not yet malignant. Metaplasia is transformation of one benign cell type into another benign cell type. "dysplasia" or "atypical hyperplasia" would be a warning of premalignancy. The chronic inflammatory cells are not cancer. This is a benign biopsy -- either no cancer or it was not at the biopsy site. Please follow up as appropriate. ...Read more
Many organs: The first likely tissue where metastases occurs in invasive ductal cancer is the lymph nodes on the armpit or behind the chest wall. Other organs may include the bones, lungs, liver, brain, adrenal glands, skin, bone marrow, the lining around the lungs or heart or the abdomen. Other parts of the body are less often sites of spread. ...Read more
Nothing: Even in the lung, squamous cell carcinomas are usually silent until they have become large enough to cause coughing up of blood -- one of the common ways in which it announces itself. On the skin, of course, a growing mass with a rough surface is (depending on how it looks) likely to be a squamous skin cancer; these are usually easy to cure. Good luck. ...Read more
There are treatments: The vast majority of neuroendocrine carcinomas in the liver originate in another site. Since the liver disease is the most common contributor to survival, we will often use liver directed therapies to control the liver component of the disease. There is an imaging techinque (ga68) used in europe that is available in certain centers in the us that can help evaluate the ds and response to trtment. ...Read moreSee 1 more doctor answer
Father65,biopsy result of nasal polyps- Moderately differentiated infiltrating keratinizing squamous cell carcinoma with areas vasaloid. is it cancer?
Unfortunate: This is usually an unfortunate situation. The most common primary site will be somewhere in the intestinal tract, like the stomach. The pathologists will try many stains on the tissue to help define the origin. This helps with choosing the most appropriate chemotherapy. ...Read moreSee 1 more doctor answer
Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?
Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more
Hepatocellular carcinoma(HCC) is a Cancer arising from the Liver. It often occurs in in people who have a chronically damaged liver due to infection with Hepatitis B or hepatitis C Virus or it can be due to use of excessive alcoho, drinking that leads to Cirrhosis which then makes you more prone ...Read more
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