Doctor insights on:
Hepatic Fibrosis In Children
Fibrosis = scarring: Inflammation of the liver, as almost anywhere else in the body, often heals with scarring. Lose enough functioning liver cells to scarring & you get cirrhosis. A fibrosis score is typically calculated during liver biopsy (& some fancier liver imagings) to calculate how much damage a chronically inflammed liver has sustained, & its risk of failing /decompensating. Then you need a liver transplant. ...Read more
Liver biopsy = hepatic parenchyma showing moderate to severe chronic hepatitis w/bridging fibrosis &focal changes of early micronodular cirrhosis. Grade 3-4 stage 3-4. Can thyroid cause this? Or what?
Recessive gene: A mutation is carried in the dna of both unaffected parents & that matching or similar mutation is paired up at conception when the sperm & egg form completed chromasomes with the defective info. Late in pregnancy and after delivery, the effect of the CF gene abnormality begins to reveal itself. In carriers, the good gene compensates for the bad & no problems occur. ...Read more
Yes but note:: 1. Cystic fibrosis may affect male fertility through a. Thick viscid semen b. Association with absence of the vas, the tubes that conduct sperm from testes to outside. Thick sperm can be easily handled with iui. Obstruction can be addressed through harvesting sperm from the testes and using it for ivf. 2. Genetic consideration: there is a risk of transmission of CF to children-genetic counseling. ...Read more
Can men with atypical cystic fibrosis have children? I have 2 children, I have no symptoms of CF and I am 32 years old. Never tested for CF.
If you mother is a carrier of cystic fibrosis is it posibble for one of her children to get it in there audlt years.?
Not going to happen: The predominant forms of CF (70%) come from inheriting a delta f508 mutation from both parents. If the biological dad does not carry a CF gene, delta f508 or any of the dozens of similar minor mutations, the kid cannot suddenly develop CF. Carrier detection is available to test any potential parent, and many suggest people know the status of both if one is a known carrier. ...Read more
My partner has cystic fibrosis (male) and I have children 3 boys to a previous relationship. I'm desperate to know if it possible to have iui?
Yes: Of course. Question is whether you are looking for a donor. If so california cryobank takes great care in helping people like you. I'm not sure that IUI with your husbands sperm is a good idea. Check me on this but if you do not carry the gene (1:26 for caucasion, carrier rate) your children may be carriers without the actual disease. Look it up and see geneticist, I'm going off top of head. ...Read more
Certainly: Cystic Fibrosis (CF) most common life-limiting genetic disorder of Caucasians, affecting approximately 30K people in the US. A, impacting mainly respiratory function. In recent years patients symptoms better controlled by genetic findings and better medications. Emotional & phys. Development depend on severity, time in hospital, complications. Morb. & mort. Factors afect emotional, cognitive behavior. ...Read more
As a carrier:
Genetic carrier testing:
more than 10 million americans are symptomless carriers of the defective CF gene. This blood test can help detect carriers, who could pass CF onto their children. To have cystic fibrosis, a child must inherit one copy of the defective CF gene from each parent. ...Read more
I have family members with cystic fibrosis. Is it possible to start show the symptoms in my 20's?
What are the chances of a child getting cystic fibrosis among the different racial groups in the u.S.?
Acording to the CF foundation: the overall birth prevalence is 1/3700. It can occur in any race, however the greatest incidence is in caucasians of northern european descent, being 1/2500. The other major groups affected are hispanics 1/13500, african americans 1/15000.
More than 10 million of us carry one part of the defective gene, but to have the disease you must have a copy from both parents. ...Read more
Retroperitoneal Fibr: Retroperitoneal fibrosis is a rare disease, often idiopathic, but drugs, infections malignancies, prior surgeries, radiation therapy, smoking, and asbestos exposure have been implicated.. It is characterized by the presence of inflammatory and fibrous retroperitoneal tissue that often encases the ureters & other abdominal organs. Symptoms include back or flank pain, and decreased kidney function ...Read more
Genetic disorder: It is a genetic disorder characterized by abnormal sodium channels, which affect a great deal of problems including the respiratory and digestive systems. It is most commonly diagnosed in infants failing to gain appropriate weight, and in children who have multiple chronic infections. ...Read more
Inherited disease: Cystic fibrosis (CF) is an inherited disease that affects the cells lining the lungs, sinuses, intestines, spleen and liver. It prevents chloride ions from crossing the cell membranes properly. This can clog organ ducts. In the lungs, the extra mucus crushes the cilia and leads to more lung infections. Medications can help; in late-stage disease, lung transplantation may be life-saving. ...Read more
Depends on genes: The risk of acquiring cystic fibrosis (CF) depends on whether the parents of a child are carriers for the gene. It is estimated that about 1 in 20 americans are carriers of the CF gene. In order for a child to acquire the disease, both parents must be carriers. If both parents are carriers, there is then a 25% chance that the child will acquire the disease. ...Read more
Cystic fibrosis: CF is a genetic disease that from birth causes the body to produce a thick and sticky mucus. This mucus interferes with the ability to breath and digest food. It is life threatening, but with good management people can live into their 40s and beyond with it. ...Read more