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Doctor insights on: Hep A Antibody Total Reflex Igm

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Dr. Gregory Lanza
816 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

Had HSV DNA PCR test with CSF?  Negative.  Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

No HSV in CNS: With these tests, you're obviously under a doctor's care, maybe including an infectious diseases specialist or neurologist. They can answer these questions best. But these results effectively rule out HSV infection of your central nervous system. Something else is causing the problem. That said, the HSV IgM test is notoriously unreliable. You probably also had an IgG test, probably negative. ...Read more

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Recently tested high levels for all 3 EBV antibodies >5 IGM,IGG,IGG(EBNA). what does this mean?

Recently tested high levels for all 3 EBV antibodies >5 IGM,IGG,IGG(EBNA). what does this mean?

Epidemiology of EBV: Studies show that the Epstein Barr Virus is ubiquitous in all human populations. Children acquire the disease and seroconvert in the first few years of life. Studies also show that EBV titers are high in young children and then in persons above 50 years old. IGM antibodies are usually seen in early infection IGG antibodies immunity or memory response. http://www.ncbi.nlm.nih.gov/books/NBK47424/ ...Read more

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I'd dengue a month back. During hectic travel, had same symptoms again. Today IgM test antibodies detected. Is it confirm I have dengue again ?

I'd dengue a month back. During hectic travel, had same symptoms again. Today IgM test antibodies detected. Is it confirm I have dengue again ?

No: Anti-dengue igm can stay around for as long as a year. The best way to make the diagnosis of a second attack is by symptoms and signs. It is often quite severe, since it's by a second variant of dengue and you're very immune to the first, so your immune system may make you seriously ill. You'll know in a short time. Hoping this is not dengue again, or that you'll get good supporting treatment. ...Read more

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How soon do antibodies change from IgM to igg?

How soon do antibodies change from IgM to igg?

No right answer: There is no right answer to this question. It depends on the virus or vaccine and it depends on the person. The answer can be anywhere from three to twenty four weeks. ...Read more

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What causes high IgG antibodies but negative igm?

What causes high IgG antibodies but negative igm?

Immunity: Igm is the first line of defense and reacts first, then long term immunity is provided by igg. So a positive igg and negative igm to something means an old exposure. ...Read more

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High IgG antibodies but negative igm. What does this mean?

Remote infection: Igm is the first class of antibody made to a microbe and after several months the immune system starts to make igg class of antibodies and then the immune system stops making igm. If all that is found is igg to a particular microbe it means that you were infected over about 6 months to many years previously. ...Read more

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Core ab +be. Igm -ve. Surface antigen -ve. Surface ab +ve. E antigen -ve. E antibody +be. I was vaccinated for hepetitis b in 1996.Explain.

Sounds good: You'll do well to discuss with your personal health care provider, but it sounds to me like you recovered from an episode of hepatitis b, perhaps before you were immunized. ...Read more

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What is the toxoplasma IgG and IgM antibody test?

What is the toxoplasma IgG and IgM antibody test?

You've met it: When one meets the toxoplasmosis organism (mild flu-like or no illness), IgM usually appears and may stay around for as long as 18 months. Igg will also appear and usually stay for life, suggesting you overcame the creatures. However, they may still be alive and dormant, to re-emerge should you become immunocompromised. ...Read more

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What does a high EBV viral capsid antibody IgM mean?

What does a high EBV viral capsid antibody IgM mean?

DIAGNOSIS IS MONO:: Acute phase of infectious mononucleosis is characterized by rapid igm and igg antibody response to viral capsid antibody(vca) in all patients. The test may remain positive from 4 weeks, occasionally up to 4 months. ...Read more

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After how many weeks after exposure does an HSV 1&2 antibody test turn from IgM to igg?

3 weeks: Approximately 50% of people will have igg antibodies detectable by 3 weeks. Most people will have igg detectable by 3-4 months and occasionally it may take up to 6 months. ...Read more

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What is the test result range for both negative & positive for HSV antibodies IgM & igg? Ex. <0.9 ... Etc

What is the test result  range for both negative & positive for HSV antibodies IgM & igg? Ex. <0.9 ... Etc

Differs by lab: What you are asking is for the normal "reference ranges" for these tests. Reference ranges are established by each laboratory based on their testing equipment and vary from lab to lab. There is no universal reference range for these or other lab tests. You would need to ask for the range at the lab where the tests were run. ...Read more

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Recent bloodwork showed an IgM level less than 5 mg/dl. Other antibodies are normal. I do not have a spleen. Could this be the reason?

Unlikely: I find your situation interesting - both are immunologic issues. But, not having a spleen would not drop your igm levels. An isolated deficiency of igm (absence of igm) is rare. Usually it is not a problem. It might be related to your gastrointestinal issues. ...Read more

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OspA (outer-surface protein A) is specific to Borrelia ONLY. I have IgM antibodies to OspA and to no other bands. What's going on here?

Serotype to other +?: OspA serotypes 3–6. Phase I/II studies with the multivalent vaccine have been initiated in humans to determine the optimal dose, formulation, and booster interval in Borrelia seronegative as well as Borrelia seropositive individuals. American patients with Lyme arthritis commonly had antibody responses to OspA, BicA, and OspD. I am not clear as to what may cross react with other substances +? ...Read more

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My rubella antibodies test report says IgG is 8.87 & IgM is 0.92 , should I need to concern with any doctors'? Can anybody help me hare?

My rubella antibodies test report says  IgG is 8.87 & IgM is 0.92 , should I need to concern with any doctors'? Can anybody help me hare?

Rubella: What are the norms for those tests in your laboratory? If you are immune to rubella (not susceptible any more), the test level breakdown usually states so. ...Read more

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IS THERE`S A PRESENT INFECTIOUS ? MY EBV ANTIBODY PANEL: VCA - IGM 43 VCA - IGG 1041 EA - IGG 295 EBNA - IGG 133

Yes, it is recent.: Presence of IGM indicates a recent infection. This type of antibody is released early as this carries five times the blocking sites compared to other antibodies. Presence of IGM thus suggests an ongoing attempt by our immune system to fight a current infection. ...Read more

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My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean?My ANA & Other antibodies Neg.

My anticardiolipins IgM has come back high in the last two years ranging from 113 to 53 recently what does this mean?My ANA & Other antibodies Neg.

Anticardiolipins: Usually that only causes a problem for the fetus. Are you thinking of getting pregnant in the near future? If not, then I would just forget about it for the moment. ...Read more

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Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own? LA Positive but beta glycoprotein & other antibodies neg

Does anticardiolipin IgM (115ug/l) x 3 have any significance when it is rasied on its own?  LA Positive but beta glycoprotein & other antibodies neg

Higher future risk: The cause of an elevated aCL without other diseases is unknown. That said, 50% of people with + lupus anticoagulant have or will have SLE. Presumably, manifestations require the aCL plus another problem - infection, one of a number of drugs, pregnancy, BC pills, etc. The significance is the higher than normal risk in the face of future immunological injury ...Read more

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How long does the IgM antibody stay in your blood before it disappears?

How long does the IgM antibody stay in your blood before it disappears?

Antibodies: This is a major class of antibody secreted into the blood in the early stages of primary response to the infection. The highest levels should be observed in the acute infection and then gradually subside. However, in human autoimmune disorders certain forms of igm could be consistently elevated. Certain abnormal igms (cryoglobulins) are associated with hematologic, autoimmune and chronic infection. ...Read more

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How long does it take for herpes IgM antibodies to disappear - for a person to test negative after exposure?

How long does it take for herpes IgM antibodies to disappear - for a person to test negative after exposure?

Herpes simplex: Positive test results for hsv-2 indicate genital herpes. If this was igm then in 6-8 weeks it should convert to igg antibodies, but this is immaterial. Either you have this or you don't and once you have it, it will remain with you for the rest of your life. We do not yet have a cure for herpes simplex viral infection. ...Read more

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Is a core positive antibody for hepetitis b is dangerous. Igm antibody negetive. Surface antigen negetive with surface antibody positive. Explain?

Is a core positive antibody for hepetitis b is dangerous. Igm antibody negetive. Surface antigen negetive with surface antibody positive. Explain?

Past infection: The results you described are consistent with a past infection with hepatitis b from which you have recovered. You body made antibodies to the constituents of the virus. These results are not a cause for concern. ...Read more

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How long do Hepatitis A IGM antibodies last after exposure/Infection?

4-6 months: detectable for 4-6 months then replaced with IgG which is probably detectable for life. ...Read more

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My hepatitis a IgM antibody value has gone down, so that means the virus is going away?

My hepatitis a IgM antibody value has gone down, so that means the virus is going away?

Yes: Hepatitis a always goes away on its own; there is no chronic form. Therefore, it's not nessary to follow the antibody titer. What matters is whether your jaundice is resolving and you're feeling better. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. Brett Kalmowitz
644 doctors shared insights

Hepatitis A (Definition)

A viral infection of your liver usually food born that will resolve over time with ...Read more