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Doctor insights on: Hep A Antibody Total Reflex Igm

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Dr. Gregory Lanza
811 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


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Had HSV DNA PCR test with CSF? Negative. Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

Had HSV DNA PCR test with CSF?  Negative.  Also had HSV 1/2 antibody (IgM), IFA with reflex to Titer, CSF. Negative. Can I still have HSV 1 or 2?

No HSV in CNS: With these tests, you're obviously under a doctor's care, maybe including an infectious diseases specialist or neurologist. They can answer these questions best. But these results effectively rule out HSV infection of your central nervous system. Something else is causing the problem. That said, the HSV IgM test is notoriously unreliable. You probably also had an IgG test, probably negative. ...Read more

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Recently tested high levels for all 3 EBV antibodies >5 IGM,IGG,IGG(EBNA). what does this mean?

Recently tested high levels for all 3 EBV antibodies >5 IGM,IGG,IGG(EBNA). what does this mean?

Epidemiology of EBV: Studies show that the Epstein Barr Virus is ubiquitous in all human populations. Children acquire the disease and seroconvert in the first few years of life. Studies also show that EBV titers are high in young children and then in persons above 50 years old. IGM antibodies are usually seen in early infection IGG antibodies immunity or memory response. http://www.ncbi.nlm.nih.gov/books/NBK47424/ ...Read more

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Recent bloodwork showed an IgM level less than 5 mg/dl. Other antibodies are normal. I do not have a spleen. Could this be the reason?

Recent bloodwork showed an IgM level less than 5 mg/dl. Other antibodies are normal. I do not have a spleen. Could this be the reason?

Unlikely: I find your situation interesting - both are immunologic issues. But, not having a spleen would not drop your igm levels. An isolated deficiency of igm (absence of igm) is rare. Usually it is not a problem. It might be related to your gastrointestinal issues. ...Read more

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I'd dengue a month back. During hectic travel, had same symptoms again. Today IgM test antibodies detected. Is it confirm I have dengue again ?

I'd dengue a month back. During hectic travel, had same symptoms again. Today IgM test antibodies detected. Is it confirm I have dengue again ?

No: Anti-dengue igm can stay around for as long as a year. The best way to make the diagnosis of a second attack is by symptoms and signs. It is often quite severe, since it's by a second variant of dengue and you're very immune to the first, so your immune system may make you seriously ill. You'll know in a short time. Hoping this is not dengue again, or that you'll get good supporting treatment. ...Read more

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How soon do antibodies change from IgM to igg?

No right answer: There is no right answer to this question. It depends on the virus or vaccine and it depends on the person. The answer can be anywhere from three to twenty four weeks. ...Read more

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What causes high IgG antibodies but negative igm?

What causes high IgG antibodies but negative igm?

Immunity: Igm is the first line of defense and reacts first, then long term immunity is provided by igg. So a positive igg and negative igm to something means an old exposure. ...Read more

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High IgG antibodies but negative igm. What does this mean?

Remote infection: Igm is the first class of antibody made to a microbe and after several months the immune system starts to make igg class of antibodies and then the immune system stops making igm. If all that is found is igg to a particular microbe it means that you were infected over about 6 months to many years previously. ...Read more

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Core ab +be. Igm -ve. Surface antigen -ve. Surface ab +ve. E antigen -ve. E antibody +be. I was vaccinated for hepetitis b in 1996.Explain.

Sounds good: You'll do well to discuss with your personal health care provider, but it sounds to me like you recovered from an episode of hepatitis b, perhaps before you were immunized. ...Read more

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. Brett Kalmowitz
644 doctors shared insights

Hepatitis A (Definition)

It is a viral infection of your liver usually food born that will resolve over time with ...Read more