Doctor insights on:
Hemophagocytic Lymphohistiocytosis Diagnosis
Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?
Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more
Bone and skin change: In Langerhans cell histiocytosis, excess immune system cells, the Langerhans cells build up . These cells, which help regulate the immune system, are normally found in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In histiocytosis, excess immature cells usually form tumors called granulomas. When granulomas develop in the bones, they cause pain, swelling and Fx. ...Read more
CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read moreSee 1 more doctor answer
Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia? Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?
No infections in MBL: The definition of mbl is an elevated lymphocyte count with a lack of symptoms or complications. It can transform into cll (chronic lymphocytic leukemia), in which low immunoglobulins and the abnormal b lymphocytes can indeed cause increased infections. Neither of these has been associated with transformation to acute leukemia, although cll can become an aggressive lymphoma. ...Read moreSee 1 more doctor answer
Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder. What can it be? Is this serious? Treat?
Please interpret pericardium tissue
mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.
Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more
Hypostatic pneumonia: Hypostatic pneumonia is a term used to describe fluid accummulation in the lower portions of lungs in bed-ridden individuals (typically elderly). One thing you can do to reduce a pneumonia risk is to have your physician provide you with an early pneumonia shot (pneumovax /ppsv-23) before age 65. ...Read moreSee 1 more doctor answer
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?
Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read moreSee 1 more doctor answer
Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?
Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more
See below...: Chronic lymphoblastic leukemia does not exist. Cll stands for chronic lymphocytic leukemia. Lymphoblastic leukemias are acute.The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy unless there are symptoms or adverse prognostic factors. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read moreSee 2 more doctor answers
Can Philadelphia chromosome positive Chronic Myeloid Leukemia turn into Pre-B-Acute Lymphoblastic Leukemia?
Chronic skin tumor: Kaposi sarcoma is a hemangio endothelial sarcoma, reddish and nodular on the skin of the lower extremity, chronic in behavior and taking years to advance. Local excision and RT control it. With HIV, an acute variant found usually on the face and virtually fatal until found to be due to immunodeficiency and Herpes 8. When immune system regulated and Herpes 8 vaccine employed the disease regresses ...Read more
Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read moreSee 1 more doctor answer