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Doctor insights on: Hemophagocytic Lymphohistiocytosis Diagnosis

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

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Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?

Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder.  Is this lymphoma?

Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more

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What is langerhans cell histiocytotis?

What is langerhans cell histiocytotis?

Abnormal cells: Langerhans cell histiocytosis (lch) involves abnormal cells developing from bone marrow which can migrate to different parts of the body. ...Read more

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What symptoms make langerhans cell histiocytosis the most likely diagnosis?

What symptoms make langerhans cell histiocytosis the most likely diagnosis?

Bone and skin change: In Langerhans cell histiocytosis, excess immune system cells, the Langerhans cells build up . These cells, which help regulate the immune system, are normally found in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In histiocytosis, excess immature cells usually form tumors called granulomas. When granulomas develop in the bones, they cause pain, swelling and Fx. ...Read more

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What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read more

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Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia? Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia?  Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

No infections in MBL: The definition of mbl is an elevated lymphocyte count with a lack of symptoms or complications. It can transform into cll (chronic lymphocytic leukemia), in which low immunoglobulins and the abnormal b lymphocytes can indeed cause increased infections. Neither of these has been associated with transformation to acute leukemia, although cll can become an aggressive lymphoma. ...Read more

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Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder. What can it be? Is this serious? Treat?

Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder.  What can it be? Is this serious? Treat?

No: Even if it's a low grade lymphoma if it's not anywhere else there's a good chance it will never come back. They should be able to tell from special tests of your thymus. Good luck. ...Read more

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Please interpret pericardium tissue mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.

Please interpret pericardium tissue 
 mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles.  Hemosiderin-laden macrophages.

Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more

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Can monoclonal b-cell lymphocytosis be an antecedent cause of hypostatic pneumonia?

Can monoclonal b-cell lymphocytosis be an antecedent cause of hypostatic pneumonia?

Hypostatic pneumonia: Hypostatic pneumonia is a term used to describe fluid accummulation in the lower portions of lungs in bed-ridden individuals (typically elderly). One thing you can do to reduce a pneumonia risk is to have your physician provide you with an early pneumonia shot (pneumovax /ppsv-23) before age 65. ...Read more

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Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy  give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

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Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?

Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more

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Chronic lymphoblastic leukemia (cll) is cll terminal? Is there a cure?

Chronic lymphoblastic leukemia (cll) is cll terminal? Is there a cure?

See below...: Chronic lymphoblastic leukemia does not exist. Cll stands for chronic lymphocytic leukemia. Lymphoblastic leukemias are acute.The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy unless there are symptoms or adverse prognostic factors. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read more

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Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Sometimes: Both ate classified as hodgkin but they can behave differetlny. Both are treated te same with chemo abvd regimen. Some new data suggest adding Rituxan (rituximab) if cd 20 positive in lymphocyte predominantly disease. ...Read more

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Is diffused b cell lymphoma genetic?

Is diffused b cell lymphoma genetic?

Not really: While there may be a genetic suscepibiltiy to developing lymphoma it is not truly a genetic disease. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

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What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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What is kaposi hemangioendothelioma lymphomatosis?

What is kaposi hemangioendothelioma lymphomatosis?

Chronic skin tumor: Kaposi sarcoma is a hemangio endothelial sarcoma, reddish and nodular on the skin of the lower extremity, chronic in behavior and taking years to advance. Local excision and RT control it. With HIV, an acute variant found usually on the face and virtually fatal until found to be due to immunodeficiency and Herpes 8. When immune system regulated and Herpes 8 vaccine employed the disease regresses ...Read more

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How is acute myeloid leukemia different from chronic lymphoma leukemia?

How is acute myeloid leukemia different from chronic lymphoma leukemia?

Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read more

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Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?

Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?

Yes: In 70 to 80 percent of cases. The availability of tyrosine kinase inhibitors such as gleevec (imatinib) has moved transplant to 3rd line treatment ...Read more