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Doctor insights on: Hemophagocytic Lymphohistiocytosis Criteria

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

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Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?

Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder.  Is this lymphoma?

Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more

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What is langerhans cell histiocytotis?

What is langerhans cell histiocytotis?

Abnormal cells: Langerhans cell histiocytosis (lch) involves abnormal cells developing from bone marrow which can migrate to different parts of the body. ...Read more

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Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia? Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia?  Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

No infections in MBL: The definition of mbl is an elevated lymphocyte count with a lack of symptoms or complications. It can transform into cll (chronic lymphocytic leukemia), in which low immunoglobulins and the abnormal b lymphocytes can indeed cause increased infections. Neither of these has been associated with transformation to acute leukemia, although cll can become an aggressive lymphoma. ...Read more

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What is nonclonal mast cell activation disorder?

What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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What are post-transplant lymphoproliferative disorders?

What are post-transplant lymphoproliferative disorders?

Tumor from Infection: Immunosuppression lowers your immune defenses. One specific infection - the epstein barr virus can be a problem because it can stimulate 1 type of white blood cells, the b lymphocytes to grow uncontrollably. If this happens, treatment may include lowering (or stopping) immunosuppression, anti-viral medication and even chemotherapy. ...Read more

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Differences between myeloid leukemia and lymphoid leukemia?

Differences between myeloid leukemia and lymphoid leukemia?

Type of cell : Lymphoid and myeloid reference the cell type involved in the leukemia. There are different cell types within the lymphoid and within the myeloid groups. We need to identify that cell type to know what treatments will be needed for that specific leukemia.. ...Read more

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Is diffused b cell lymphoma genetic?

Is diffused b cell lymphoma genetic?

Not really: While there may be a genetic suscepibiltiy to developing lymphoma it is not truly a genetic disease. ...Read more

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Please interpret pericardium tissue mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles. Hemosiderin-laden macrophages.

Please interpret pericardium tissue 
 mononuclear infiltrates with rare polymorphnuclear leukocytes & eosinophiles.  Hemosiderin-laden macrophages.

Not tumor: This is the site of an old bleed and probably infection or physical injury. The key is that there's not tumor found. Any interpretation beyond this without a history would be meaningless. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

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What type of leukemia involves immature white blood cells: lymphocytic or myeloid?

Leukemias: Acute leukemias are those with large numbers of immature cells that grow quickly. They can be either myeloid or lymphoid in lineage. Chronic leukemias have more mature cells, a longer course, but can also be myeloid or lymphoid. A hematologist/oncologist is generally the treating physician, and a hematopathologist is the one who give the specific syping. ...Read more

Dr. Liawaty Ho Dr. Ho
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What percent of leukemias does acute myeloid leukemia represent?

Dr. Liawaty Ho Dr. Ho
1 doctor agreed:
What percent of leukemias does acute myeloid leukemia represent?

AML: AML is the most common acute leukemia in adults and accounts for approximately 80 % of cases in this group. In us and europe, the incidence has been stable at 3 to 5 cases per 100, 000 population. In contrast, AML accounts for less than 10 % of acute leukemias in children less than 10 years of age. ...Read more

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Is Adult Pulmonary Langerhans Cell Histiocytosis considered a form of cancer?

Is Adult Pulmonary Langerhans Cell Histiocytosis considered a form of cancer?

Yes: However, it's curious -- it can often regress when the tobacco smoke that is its growth factor is withdrawn. The whole "histiocytosis X" family are a proliferation of cells that are invasive by nature, so by definition there are no benign tumors arising from these cells. I wish you a speedy recovery. ...Read more

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What is myelodysplastic syndromes (mds)?

What is myelodysplastic syndromes (mds)?

Bone marrow disease: MDS is a disease of bone marrow that causes blood precursor cells to have an abnormal appearance ("dysplasia"), and prevents normal production of mature RBC or WBC. This can cause seriously low blood cell counts. It arises from gene mutations acquired during your lifetime, in bone marrow cells. There is a risk that, with additional mutations, it can evolve into acute leukemia. ...Read more

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Hb 10.3, platelets 105000, normoblasts=03/100wbcs. Rbcs morphology is normochromic. Normocytic majority of lymphocytes are atypical. Mononeuclear smal?

Hb 10.3, platelets 105000, normoblasts=03/100wbcs. Rbcs morphology is normochromic. Normocytic majority of lymphocytes are atypical. Mononeuclear smal?

We can't answer: Especially with the abnormal morphology of the lymphocytes, you need to speak either with the treating physician -- primary care or consulting hematologist -- or with a physician you trust. No one here can tell you what this means though it is of course very concerning. ...Read more

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Adult male,bone marrow biopsy show Erythroid hyperplasia RBC borderline on high side,thrombocytopenia fluctuate, Splenomegaly,negative for infections.

Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.

CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more

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Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder. What can it be? Is this serious? Treat?

Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder.  What can it be? Is this serious? Treat?

No: Even if it's a low grade lymphoma if it's not anywhere else there's a good chance it will never come back. They should be able to tell from special tests of your thymus. Good luck. ...Read more