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Doctor insights on: Hemoglobinopathy Indices

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What makes some hemoglobinopathies unstable?

What makes some hemoglobinopathies unstable?

Trait vs disease.: Hemoglobinopathies are a variety of inherited diseases where the hemoglobin molecule (part of RBC that attaches to o2 which all cells need to live) is malformed. Examples are sickle cell & thalassemia anemia. Abnormal gene from one parent, usually have 'trait' and live healthy life. Gene from each parent, get the disease: infection, stress, a cold, other events can set off a crisis and instability. ...Read more

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Dr. William Reed
32 doctors shared insights

Hemoglobinopathies (Definition)

Hemoglobinopathies are disorders of hemoglobin synthesis susch as sickle cell disease and thalassemia. Most result in anemia of varying degrees, and can cause other problems depending on the type ...Read more


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Is there only one type of hemoglobinopathy?

Is there only one type of hemoglobinopathy?

No: There are several types of hemoglobinopathies including c disease, sc disease, sickle cell, and the different types of thalassemias. ...Read more

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What are the different types of hemoglobinopathies?

What are the different types of hemoglobinopathies?

Various: These relate to hemoglobin, the molecule that helps transport oxygen, and is made of 4 subunits. Adults have 2alpha & 2beta, while kids have 2alpha & 2gamma. Other minor forms also exist. Any disorder that alters these subunits can lead to hemoglobinopathy, some of which have no significance (d and e) and others that may (thalassemia & sickle cell). ...Read more

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Hemoglobinopathies, do they require treatment?

Hemoglobinopathies, do they require treatment?

Most so not: Most have altered hemoglobin in the form of "trait." Those individuals may only have small red cells but no anemia. However, patients who have full blown hemoglobinopathy are usually anemic. There are many forms of hemoglobinopathies... Such as thalassemia. Sickle cell disease vs trait is another type of altered hemoglobin. ...Read more

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What blood tests confirm the diagnosis of hemoglobinopathies?

What blood tests confirm the diagnosis of hemoglobinopathies?

Hbg electrophoresis: The usual approach is to perform a hemoglobin electrophoresis. On occasion other more esoteric specific testing may be required depending on the patient's manifestations and family history of known type. You should be seeing a hematologist. ...Read more

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What is the definition or description of: thalassemia and hemoglobinopathy?

Hereditary anemia: Thalassemia is a type of hemoglobinopathy. It is inherited from one or both of your parents. There are many kind of thalassemia. Most causes anemia (low red blood cell count). Anemia couod be severe requiring blood. Taking iron does not cure the disease. Thalassemia is common in people living in the mediteranian countries, africa, middle east, india, and sotheastern asia such as thailand, laos, et. ...Read more

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What makes some hemoglobinopathies unstable?

Trait vs disease.: Hemoglobinopathies are a variety of inherited diseases where the hemoglobin molecule (part of RBC that attaches to o2 which all cells need to live) is malformed. Examples are sickle cell & thalassemia anemia. Abnormal gene from one parent, usually have 'trait' and live healthy life. Gene from each parent, get the disease: infection, stress, a cold, other events can set off a crisis and instability. ...Read more

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What are some symptoms of hemoglobinopathies?

What are some symptoms of hemoglobinopathies?

Depends on disease: Thalassemia and sickle cell disease are the two most common hemoglobinopathies. They both have very different symptoms. Thal patients may have symptoms of anemia like feeling tired and some may need life long blood transfusions. Sickle patients may have pain crisis, infections, chest crisis, strokes, chronic organ damage. ...Read more

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What is the definition or description of: hemoglobinopathies?

What is the definition or description of: hemoglobinopathies?

Hemoglobinopathies: Hemoglobinopathies are disorders of hemoglobin synthesis susch as sickle cell disease and thalassemia. Most result in anemia of varying degrees, and can cause other problems depending on the type of abnormal hemoglobin produced. ...Read more

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Can people with hemoglobinopathy donate their blood?

Can people with hemoglobinopathy donate their blood?

Some can: For example , those with sickle cell trait can give but not sickle cell disease. For an extensive listing of doner information and qualifications go to www.Redcrossblood.Org ...Read more

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What does it mean if I'm a carrier of beta chain-related hemoglobinopathy and spinal muscular atrophy?

What does it mean if I'm a carrier of beta chain-related hemoglobinopathy and spinal muscular atrophy?

Carrier status: SMA is an autosomal recessive neuromuscular disease To be a carrier means you have one 5q deletion on chromosome 5. Beta chain hemoglobinopathy means you have an altered beta chain of hemoglobin as seen in diseases such as sickle cell. Carrier status means you do not have disease but have ability to pass it on to offspring who will have disease if other parent is carrier and passes it on as well. ...Read more

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A 4 month old's hemoglobinopathy test is indeterminate. Mother is fa and father is aa ( both normal). Is the baby atrisk?

A 4 month old's hemoglobinopathy test is indeterminate. Mother is fa and father is aa ( both normal). Is the baby atrisk?

Not likely: This is a bit unusual. In a condition known as hereditary persistence of fetal hemoglobin (hpfe) there is an elevated amount of fetal hemoglobin present. This is reported as af, as there is always more HGB a than f present, unless you have thalassemia trait as well. If mom is not anemic, shouldn't be a problem. Not sure what testing was done to demonstrate that dad is aa rather than a/thal though. ...Read more

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I have a hemoglobinopathy (not sickle cell or thalassemia). At what point is medication considered for my anemia?

I have a hemoglobinopathy (not sickle cell or thalassemia). At what point is medication considered for my anemia?

Symptoms or severe: Depends on specific etiology, as treatments may vary significantly. Generally aggressive tx like transfusions are avoided except in emergencies, but other tx will be considered if there are sxs (like dizziness, weakness, shortness of breath) or if the blood level is low enough to cause other issues (e.g., high-output heart failure). Diet may be important as well in minimizing or avoiding meds. ...Read more

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Is the Skyla IUD less effective than the Kyleena IUD? Please discuss specific pearl indices and failure rates.

Is the Skyla IUD less effective than the Kyleena IUD? Please discuss specific pearl indices and failure rates.

Equally effective: These are both equally effective. There are quoted as over 99% effective. It is not likely that a Healthtap doctor can quote the Pearl index for each specific product of the top of their head but the manufacturers website will list this information inside the package insert describing the instructions for use. ...Read more

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Do WBC differential counts fluctuate alot more than RBC indices and why ? And are absolute WBC differential count supposed to be a fixed number thanks

Do WBC differential counts fluctuate alot more than RBC indices and why ? And are absolute WBC differential count supposed to be a fixed number thanks

Cortisol effect: Cortisol present in the blood undergoes diurnal variation; the level peaks in the early morning (approximately 8 a.m.) and reaches its lowest level at about midnight-4 a.m. High glucocorticoid levels simultaneously increase the circulating number of neutrophils (neutrophilia) and decrease the circulating number of lymphocytes (lymphopenia) and monocytes (monocytopenia). ...Read more

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My results read as followed CBC (H/H, RBC, INDICES, WBC, PLT) OUT OF RANGE 79HIGH Can you please explain I'm very concerned.

My results read as followed CBC (H/H, RBC, INDICES, WBC, PLT) OUT OF RANGE 79HIGH Can you please explain I'm very concerned.

Unclear: Please send us the complete report of your CBC with name of the test followed by its actual value. Right now I can not tell what is 79??? Is it neutrophil percentage??? ...Read more

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My ultrasound report says that Live fetus of 34W 1D Gestational size,With Doppler indices(Small for Gestational Age);LMP GSA is 36W 5D,ur recomendatio?

My ultrasound report says that Live fetus of 34W 1D Gestational size,With Doppler indices(Small for Gestational Age);LMP GSA is 36W 5D,ur recomendatio?

Doctor visit: You will need to review the sonogram with the doctor treating your pregnancy. They can evaluate your gestational dating criteria. Previous sonograms can be used as points of comparison. They can also calculate the estimated fetal weight to confirm that growth restriction is not occurring. Any further testing can be ordered if needed ...Read more

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My CBC (H/H, RBC, indices, WBC, PLT) RDW came back at 18.6 what does that indicate.

My CBC (H/H, RBC, indices, WBC, PLT) RDW came back at 18.6 what does that indicate.

Not much: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, if rest of the parameters are in the normal range, a slightly elevated RDW is not of concern. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Can you please describe the downsides of mixing refractive indices for eye glasses lenses?

Can you please describe the downsides of mixing refractive indices for eye glasses lenses?

Don't do it: Here are the issues: glasses will look funny; this may induce a difference in the way things look between eyes making the glasses intolerable. If you go ahead and do this and you get used to it, all of your future glasses will have to be made in the same, unusual way. ...Read more