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Doctor insights on: Hemoglobin's Beta Thalassemia

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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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Dr. Craig MacArthur
67 doctors shared insights

Beta Thalassemia (Definition)

A genetic blood disorder that limits a person's ability to produce hemoglobin, thus leading to anemia due to an inadequate amount ...Read more


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What is hemoglobin E-beta thalassemia?

What is hemoglobin E-beta thalassemia?

Sever anemia: This syndrome is quite common in Thailand ,where there. is a high incidence of the genes for B0 thalassemia and Be golobin ...Read more

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Are hb s levels elevated with beta thalassemia trait?

No: With beta thalassemia trait alone, no hemoglobin s should be detected. If hemoglobin s is being detected in addition to beta thalassemia trait then the patient has a form of sickle cell beta thalassemia disease. ...Read more

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Is beta thalassemia major andd hb e/beta thalassemia same?

Is beta thalassemia major andd hb e/beta thalassemia same?

Not the same.: Hemoglobin e is found in the asian population frequently and may be seen with thal trait. Thal major is a serious problem requiring much intervention, including transfusions and frequently splenectomy. Your doctor should be your guiding you. Pregnancy needs to be discussed with your doctor. ...Read more

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What is beta thalassemia?

What is beta thalassemia?

Beta thalassemia: is a genetic defect of impaired hemoglobin production, resulting in a varying degree of anemia. ...Read more

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What causes hemoglobin E-beta thalassemia?

What causes hemoglobin E-beta thalassemia?

Thalassemia : This is a genetic hemolytic blood disorders transmitted to you from your parents in your genes & instead of having the normal Hgb A, it becomes abnormal Hgb. there are different types of thalassemia. If both parents are carriers or have the disease then the offspring might get the disease. I hope this helps. Good luck. ...Read more

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Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Can an alpha thalassemia carrier marry a beta thalassemia carrier?

Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more

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My baby have hb e/beta thalassemia? Is it sickle cell disease?

No: It is not sickle cell disease. It is a "hemoglobinopathy" or genetic disorder of hemoglobin...And it can cause anemia. Sickle cell has malformed red blood cells that become "sickle" shaped and can get stuck in organs and vessels and cause pain. E/beta thalassemia is different. ...Read more

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What is thalassemia and thalassemia trait?

What is thalassemia and thalassemia trait?

Cooley's Anemia: Thalassemia is a blood disorder passed down through families (inherited) in which the body makes an abnormal form of hemoglobin, the disorder results in excessive destruction of red blood cells, which leads to anemia. Thalassemia trait is a genetic possibility you pass on to your offspring. The most important reason for discovering if you carry the thalassemia trait is this: if two people who each. ...Read more

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What is trait thalassemia?

Ok: Thal trait is different from thal major--the trait has one chromosome for this disease and the full disease means each parent gave the trait and that the child got a thalassemia gene from each parent which can cause thal major, a very serious and transfusion requiring process. There are different types of thalassemia--some more concerning than others. Please ask your doctor. ...Read more

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Is alpha thalassemia trait the same thing as alpha thalassemia?

Is alpha thalassemia trait the same thing as alpha thalassemia?

Not quite: Normal people have 4 Alpha globulin genes. Mutations in 1, 2, 3, or all 4 of the genes cause the 4 levels of Alpha thalassemia. One mutation = silent carrier (no symptoms), 2 mutat. = Alpha trait (mild anemia), 3 mutat. = HGB h disease (anemia sometimes needing transfusions), 4 mutat. = bart's disease (fatal before birth in almost all cases; lifelong transfusions needed to survive if born alive). ...Read more

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What is the alpha thalassemia trait?

Inherited defect: Our regular hemoglobin is composed of Alpha and beta chains that come together to form working hemaglobin. Alpha thalassemia trait occurs when a person inherits a defective Alpha chain gene from one parent & a normal Alpha chain gene from the other. This causes some reduction in Alpha chain production with resulting mild anemia. ...Read more

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Is hb e beta thalassemia cureble? Is it a trait or disease?

Genetic disorder: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3237252/ "the disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. "...."careful tailoring of treatment is required for each patient, and that therapeutic approaches should be re-assessed over-time." not curable..Look at website-. ...Read more

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Why anemia caused when hb is "hb e/beta thallassemia?

Need more info.: The pattern of your blood counts over the years would be helpful. Many asian populations have hemoglobin e. Beta thal trait is also frequently seen. You need to see your hematologist to clarify what is going on and any potential treatments. Good luck. ...Read more

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Beta thalesemic carrier state...Meaning?

Beta thalesemic carrier state...Meaning?

Genes: To have beta thalessemia, you have to have 2 copies of a particular gene. If you only have 1 copy, you don't have the disease, but you do carry the trait, and can pass it to your children. If your partner also is a carrier of the gene, then there is a 1 in 4 chance that your child will have beta thalessimia. ...Read more

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Is hgb e/beta thalassemia is dangerous for survive?Is it major thalassemia?

Manifestations vary: Hgb e/b-t results from inheritance of a HGB e mutation from one parent and a beta-thalassemia mutation from the other parent. The severity of HGB e/b-t varies from mild to severe. ~50% of individuals who have HGB e/b-t have severe manifestations that resemble thalassemia major. ~50% of individuals who have HGB e/b-t have symptoms similar to thalassemia intermedia. ...Read more

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Can a person wtih alpha thalassemia trait donate blood?

Can a person wtih alpha thalassemia trait donate blood?

Maybe: A person with Alpha thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read more

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Do hb e/beta thalassemia anemia reduce life expectancy?

Not necessarily: Did you look at the website reference i sent? It is quite informative. You will be best served with a visit to a specialist to get all your questions answered. It is clear you are so worried about this, and it would be so much more reassuring to have a face to face visit with someone who can answer all your great questions. ...Read more

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What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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Dr. Michael Engel
279 doctors shared insights

Thalassemia (Definition)

An inherited condition characterized by severe anemia (a deficiency of red blood cells), ...Read more