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Doctor insights on: Hemoglobin Electrophoresis Sickle Cell Anemia

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I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

Yes: Sick led cells are readily seen on a peripheral blood smear. It's worth knowing that the irreversibly sick led cells that you see on a smear are not necessarily the ones that cause the problem. In order for a cell at risk for sickling to occlude the small blood vessels (capillaries), they first must be able to enter them. In other words they must be deformable. They become occlusive in the vessel. ...Read more

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Electrophoresis (Definition)

Elecrophoresis is a process of running an electrical current through a matrix and separating items based on how fast they move through the matrix. Frequently in science and medicine, proteins or dna/rna is separated on gel based on the ...Read more


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Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Epigenetics and drug: We know that sickle cell patients that have increased Hemoglobin F typically have less sickle cell complications. This is the basis for using Hydroxyurea in sickle cell patients. Some individuals have elevated Hemoglobin F levels due to differences in the genetic region of the beta and gamma globin genes that prevent the normal shutting-off of the gamma globin gene. This leads to increased HGB f. ...Read more

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Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Yes: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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Will a hemoglobin electrophoresis tell me which anemia i have?

Will a hemoglobin electrophoresis tell me which anemia i have?

Anemia tests: More frequently done are complete blood count (to check hemoglobin, hemotocrit, other parameters), iron, ferritin, tibc, transferrin saturation, B12 level, sickle cell test. Protein electrophoresis might be used to test for abnormal hemoglobins such as those in sickle cell or in thalassemia. ...Read more

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How is living with sickle cell anemia/disease?

Depends on the sever: It all depends on what kinds of sickle cell anemia you have and how severe it is. For instance someone with sickle cell trait may have no problems whatsoever. ...Read more

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Can sickle-cell anemia be detected from a test?

Can sickle-cell anemia be detected from a test?

Yes: Certain blood work - i.e. Cbc, and a hemoglobin electrophoresis, - would need to be done to establish a diagnosis of sickle cell anemia. ...Read more

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Can you develop sickle cell anemia as an adult?

Can you develop sickle cell anemia as an adult?

Yes: You may not manifest sickle cell anemia until later in life. However, you don't develop or acquire sickle cell anemia at some point in life. It is genetic so you had it since birth. ...Read more

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What can cause the symptoms of sickle cell anemia?

Anemia itself : Causes some symptoms. Sickle cells can decrease flow to organs and lead to bone pain and chest syndrome. ...Read more

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What is the long-term outlook for sickle cell anemia?

Sickle cell future: As we better understand sickle cell disease, we hope to increase the quality of life for those affected by this disease. It is essential for those who have this disease to see a physician who specializes in sickle cell. For those with very severe disease, bone marrow transplantation may offer a cure. For others, screening and healthy lifestyle choices will help manage their disease. ...Read more

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What parts of the body does sickle cell anemia effect?

What parts of the body does sickle cell anemia effect?

Everything: Pretty much everything. As the problem is on the red blood cell itself and red blood cells are circulating through out the whole body and every organ systems in the body. It will definitely affect the bone marrow, the blood system, as well as other organs like kidney, lung, vasculature, brain, heart etc. ...Read more

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Can you explain a punnet square of sickle cell anemia ?

Can you explain a punnet square of sickle cell anemia ?

In 400 words?: This sounds like homework. This is simple mendelian genetics, the old 1:2:1 ratio of outcomes if two carriers mate. So if two sickle carriers mate, 1/4 offspring will be wild-type, 2/4 will be carriers, and 1/4 will have full-blown sickle cell disease. http://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/mendel1.htm. ...Read more

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What is most commonly affected with sickle cell anemia?

What is most commonly affected with sickle cell anemia?

Several symptoms: Sickle cell anemia leads to pain in the bones. It can also lead to shortness of breath, fatigue, chest pain, strokes. ...Read more

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Why is sickle cell anemia so painful? I need some advice.

Why is sickle cell anemia so painful? I need some advice.

More info needed: Sickle cell disease is so painful because the sickled cells criss cross in the tiny blood vessels and decrease blood flow to areas downstream of the vessel. This causes pain because new oxygen and nutrients cannot be delivered and cell waste and co2 cannot be efficiently handled. As a 38 year old with sickle cell disease, you must have had excellent care and recommendations by your doctors. ...Read more

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What impact does sickle cell anemia have on the individual?

What impact does sickle cell anemia have on the individual?

Several symptoms: Sickle cell anemia leads to pain in the bones. It can also lead to shortness of breath, fatigue, chest pain, strokes. It affects the bones, brain, kidneys, heart, joints, lungs and spleen. ...Read more

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Please describe another medical name for sickle cell anemia?

Sickle cell anemia: Sickle cell anemia is the medical name. You might also hear sickle cell disease, hemoglobin ss, hemoglobin s/beta thal, or hemoglobin sc depending on the type of sickle cell anemia that you have. ...Read more

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If I adopt a child with sickle cell anemia, what should I expect?

If I adopt a child with sickle cell anemia, what should I expect?

Talk to a specialist: They can be well a lot but can have a lot of pain issues, pulmonary problems, more infections than other kids, maybe need transfusions and can be overwhelming if you do not know what you are getting in to. ...Read more

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What are effective ways to treat the symptoms of sickle cell anemia?

See below: Sickle cell anemia can be very difficult to treat. Avoiding any known precipitating circumstance may help. Keep well hydrated. There are medications that may help if crises are frequent or severe. Blood (exchange) transfusions may also help if crises are severe or frequent. Consult with a hematologist who treats people with sickle cell anemia. ...Read more

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Can you please tell me how sickle cell disase and sickle cell anemia differ?

Can you please tell me how sickle cell disase and sickle cell anemia differ?

It depends: This often gets confusing because doctors don't always use terms the same way. Sickle cell anemia typically refers to the condition where a person inherits two s genes; by convention hematologists call this ss. This is also a type of sickle cell disease, but often hematologist include other diseases like sc disease (one s gene, one c gene) or s/beta thal under the umbrella of sickle cell disease. ...Read more

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Dr. James Ball
354 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more


Dr. Steven Ginsberg
1,276 doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more