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Doctor insights on: Hemoglobin Electrophoresis Sickle Cell Anemia

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I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

I know that the typical test for sickle-cell anemia is a hemoglobin electrophoresis, but will you be able to see the sickle shape of the blood cells?

Yes: Sick led cells are readily seen on a peripheral blood smear. It's worth knowing that the irreversibly sick led cells that you see on a smear are not necessarily the ones that cause the problem. In order for a cell at risk for sickling to occlude the small blood vessels (capillaries), they first must be able to enter them. In other words they must be deformable. They become occlusive in the vessel. ...Read more

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Dr. James Ball
348 doctors shared insights

Sickle Cell Disease (Definition)

This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more


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Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Some adults with sickle cell anemia have high levels of fetal hemoglobin. Any reason for this?

Epigenetics and drug: We know that sickle cell patients that have increased Hemoglobin F typically have less sickle cell complications. This is the basis for using Hydroxyurea in sickle cell patients. Some individuals have elevated Hemoglobin F levels due to differences in the genetic region of the beta and gamma globin genes that prevent the normal shutting-off of the gamma globin gene. This leads to increased HGB f. ...Read more

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Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Is abnormal hemoglobin is a key characteristic of sickle cell anemia?

Yes: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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Will a hemoglobin electrophoresis tell me which anemia i have?

Will a hemoglobin electrophoresis tell me which anemia i have?

Anemia tests: More frequently done are complete blood count (to check hemoglobin, hemotocrit, other parameters), iron, ferritin, tibc, transferrin saturation, B12 level, sickle cell test. Protein electrophoresis might be used to test for abnormal hemoglobins such as those in sickle cell or in thalassemia. ...Read more

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How is living with sickle cell anemia/disease?

Depends on the sever: It all depends on what kinds of sickle cell anemia you have and how severe it is. For instance someone with sickle cell trait may have no problems whatsoever. ...Read more

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Can sickle-cell anemia be detected from a test?

Can sickle-cell anemia be detected from a test?

Yes: Certain blood work - i.e. Cbc, and a hemoglobin electrophoresis, - would need to be done to establish a diagnosis of sickle cell anemia. ...Read more

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Can you develop sickle cell anemia as an adult?

Can you develop sickle cell anemia as an adult?

Yes: You may not manifest sickle cell anemia until later in life. However, you don't develop or acquire sickle cell anemia at some point in life. It is genetic so you had it since birth. ...Read more

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What can cause the symptoms of sickle cell anemia?

Anemia itself : Causes some symptoms. Sickle cells can decrease flow to organs and lead to bone pain and chest syndrome. ...Read more

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What is the long-term outlook for sickle cell anemia?

Sickle cell future: As we better understand sickle cell disease, we hope to increase the quality of life for those affected by this disease. It is essential for those who have this disease to see a physician who specializes in sickle cell. For those with very severe disease, bone marrow transplantation may offer a cure. For others, screening and healthy lifestyle choices will help manage their disease. ...Read more

Dr. Steven Ginsberg
1,239 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more


Electrophoresis (Definition)

Elecrophoresis is a process of running an electrical current through a matrix and separating items based on how fast they move through the matrix. Frequently in science and medicine, proteins or dna/rna is separated on gel based on the ...Read more