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Doctor insights on: Hemochromatosis Liver Disease

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Ferritin high 425 ug/l but iron & UIBC normal - has fatty liver disease - could this be hemochromatosis or is it the inflammation from liver disease?

Ferritin high 425 ug/l but iron & UIBC normal - has fatty liver disease - could this be hemochromatosis or is it the inflammation from liver disease?

Both: a ferritin level above 300 in a male usually indicates iron overload from hemochromatosis. It is also high in other causes of liver inflammation so more specific testing is necessary to differentiate hemochromatosis from others. Genetic testing, imaging, and biopsy are options ...Read more

Dr. James Chapman
2 doctors shared insights

Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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My mum has non alcoholic fatty liver disease & just been diagnosis with type2 diabetes - her ferritin has been very high - could hemochromatosis be cause?

My mum has non alcoholic fatty liver disease & just been diagnosis with type2 diabetes - her ferritin has been very high - could hemochromatosis be cause?

May need liverbiopsy: Although blood testing (measurement of iron studies and hfe assay) combined with family history can be very suggestive, a liver biopsy with iron staining clinches a diagnosis of hemochromatosis and distinguishes it from other iron overload diseases. Ferritin by the way can also be reactive or a secondary phenomenon. ...Read more

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Can a person with skin bronzing symptom have hemochromatosis if his liver function tests are normal?

Can a person with skin bronzing symptom have hemochromatosis if his liver function tests are normal?

Yes: Patients with hemachromatosis do not always have elevated liver enzymes. It is possible to have bronzing of the skin without elevated liver enzymes. All of these manifestations would be uncommon at 19 years old as end organ damage generally takes decades. ...Read more

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Is it possible for someone to show normal liver function test and still have hemochromatosis?

Is it possible for someone to show normal liver function test and still have hemochromatosis?

Yes: A majority of hemochromatosis patients do have elevated transaminases especially later. If you have the high serum ferritin and/or symptoms and/or genetic studies sufficient to justify starting phlebotomy, don't hesitate. ...Read more

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What are my chances of having liver cancer as a result of having hemochromatosis?

What are my chances of having liver cancer as a result of having hemochromatosis?

Are you compliant?: If you are getting phlebotomy and keeping your ferritin where it should be, your risk is low. If not, and you're iron-overloaded, you are setting yourself up for cancer. I can't give you the percentage odds and neither can anyone else even if they are very familiar with you. But they're high enough to want to avoid. ...Read more

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Must I have a liver biopsy to confirm a diagnosis of hemochromatosis before I can begin treatment?

Must I have a liver biopsy to confirm a diagnosis of hemochromatosis before I can begin treatment?

I say no: I think I'm in the majority. If it's obvious that you have the disease (very high ferritin and symptoms / imaging findings, and/or mutant HFE gene), I think most physicians will treat you. ...Read more

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Discrete coarsened increased echogenicity of the liver with history of hemochromatosis meaning on ultrasound?

This is : A nonspecific finding on ultrasound though hemochromatosis in one of the many things that can cause this appearance. Magnetic resonance imaging (MRI) is the best imaging examination to evaluate abnormal iron deposition in the liver. ...Read more

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Hemochromatosis is always hereditary or congenital? I have cirrhosis in the liver and moderate iron accumulation, which one caused the other one?


Hemochromatosis is always hereditary or congenital? I have cirrhosis in the liver and moderate iron accumulation, which one caused the other one?

Need more info: How was diagnosis made? ferritin >200 with % iron bound >50%? unfortunately, the liver bx is unreliable for determining amount of iron accumulation, as one are may be normal and another area may be very high. Were you found homozygous for specific predisposing genes? If not homozygous, it is not likely genetic. Have they started therapy? Look up N-acetyl cysteine in Wikipedia. ...Read more

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Symptoms of liver disease?

Symptoms of liver disease?

Multiple symptoms: Liver disease has a multitude of symptoms. In the early phases it can be nonspecific like tiredness, lack of appetite ; energy, distaste for cigarettes, yellowish discolouration of eyes ; urine. With increasing loss of liver function, 1) fluid retention (belly/ankle swelling, 2) mental changes(confusion), 3) bleeding from the mouth or rectum, on in the skin. Hope this helps. ...Read more

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Is liver disease really serious?

Is liver disease really serious?

Could be: There are many varieties of "liver disease." hepatitis c can cause eventual cirrhosis. Alcohol excess can cause cirrhosis. Some liver disease caused by hepatitis a or b or from some medications can fully resolve with no further problems. Fatty liver damage can rarely progress to a serious problem. So it depends. Your doctor would know best what a person's future risks may be. ...Read more

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Dr. Anne Larson
1,586 doctors shared insights

Liver Diseases (Definition)

Liver diseases include genetic problems such as Wilson's disease, infection, inflammation, and cancer. The liver carries out many functions in our body including metabolizing drugs and ...Read more


Dr. (Liz)Phuong Tran
316 doctors shared insights

Hemochromatosis (Definition)

Hemochromatosis is a medical condition caused by iron accumulation in the body. It can be the result of underlying hereditary disease or be due ...Read more