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Doctor insights on: Help Me With Understanding Agonist And Antagonist Drug Actions

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Help me with understanding agonist and antagonist drug actions?

Help me with understanding agonist and antagonist drug actions?

Stimulating vs block: Agonists are stimulators of receptors and antagonists are blockers of receptors. ...Read more

Agonist (Definition)

An agonist is a chemical that binds to a receptor on a cell and triggers a response by that cell. An agonist usually mimics the action of the naturally occuring substance. An antagonist does just the opposite, blocking the ...Read more


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What happens if a certain poison/drug blocks the receptor site for a particular neurotransmitter, is it considered an agonist or an antagonist?

Could be either: We have both excitatory neurotransmitters (such as glutamate, glycine), and many inhibitory neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin), and some agents can interfere by imbalancing the homeostasis. However, mechanistically, receptor blockers really cannot be considered in either category. ...Read more

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Can anyone tell me is Zoloft (sertraline) an agonist or antagonist?

Can anyone tell me is Zoloft (sertraline) an agonist or antagonist?

SSRI: Zoloft (sertraline) is a selective serotonin re-uptake inhibitor. It stops the nerve cell from removing the neurotransmitter serotonin from the synapse, thus making more serotonin available to the cell. In theory it temporarily disengages the re-uptake mechanism. ...Read more

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Why night you use an opioid agonist-antagonist?

Why night you use an opioid agonist-antagonist?

Opiate addiction: Opioid agonist antagonist like buprenorphine are commonly used to help people addicted to heroin or other opiate agonists ...Read more

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Can you tell me how is it possible that buprenorphine and butorphanol are partial agonists-antagonists?

Can you tell me how is it possible that buprenorphine and butorphanol are partial agonists-antagonists?

Agonist/antagonist: They are agonists at some receptor types and antagonist at other receptor types. Also agonist/antagonist effects may also be dose dependent as well. ...Read more

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Can I take remeron (mirtazapine) and guanfacine together? Remeron (mirtazapine) is an a2 antagonist and guan is an a2 agonist. Would these compliment each other or cancel out?

Can I take remeron (mirtazapine) and guanfacine together? Remeron (mirtazapine) is an a2 antagonist and guan is an a2 agonist. Would these compliment each other or cancel out?

Well ...: These 2 medicines would not be an ideal combination as they do interact as you mentioned. Mainly you'd be concerned about a dystegulation on your blood pressure. There are a lot safer & frankly better alternatives out there - depending on what you're taking them for. Always better safe than sorry ... Hope that helps! ...Read more