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Doctor insights on: Has Anyone Tried Fluoxetine Or Duloxetine For Fibromyalgia

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Has anyone tried fluoxetine or duloxetine for fibromyalgia?

Has anyone tried fluoxetine or duloxetine for fibromyalgia?

Duloxetine for Fibro: There are now three drugs that have been approved by the fda for the treatment of fibromyalgia-duloxetine (cymbalta), lyrica (pregabalin), (pregabalin) and milnacipran (savella). Studies has shown no difference in effectiveness between savella and cymbalta. We usually use one of the two along with lyrica (pregabalin). This combination has been the first medications to provide real benefit to fibromyalgia patients in years. ...Read more

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Dr. Heidi Fowler
1,040 doctors shared insights

Fluoxetine (Definition)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better ...Read more


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Hi! I'm switching from a daily dose of 30mg Duloxetine to 20mg Fluoxetine. Do I need to taper off Duloxetine, or can I switch immediately?

Hi! I'm switching from a daily dose of 30mg Duloxetine to 20mg Fluoxetine. Do I need to taper off Duloxetine, or can I switch immediately?

Switching Medication: I understand your need for improvement in Depression and Anxiety. Duloxetine (Cymbalta) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Fluoxetine is a SSRI medication. See Psychiatrist and inform about side effects of Duloxetine, and discuss risks of sudden withdrawal from it; discuss benefits and side effects of Fluoxetine; and Therapy for stresses in life. ...Read more

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What is the chemical difference between duloxetine and fluoxetine?

What is the chemical difference between duloxetine and fluoxetine?

Differences: These two medicines share similarities, but they have different chemical structures, leading to different actions on the nervous system. Fluoxetine almost exclusively acts on the neurotransmitter serotonin, while duloxetine has a mixed action on both serotonin and norepinephrine. This difference will sometimes result in a person doing better with one medicine versus the other. ...Read more

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What is the difference between fluoxetine and duloxetine in effects on weight?

What is the difference between fluoxetine and duloxetine in effects on weight?

Varied: Fluoxetine can initially decrease appetite, but has been associated with weight gain with prolonged use. Duloxetine can also cause initial weight loss and is less likely to cause weight gain over time. ...Read more

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Hi IV recently gone from 40mg fluoxetine a day to starting duloxetine 30mg. Is duloxetine stronger than fluoxetine ? Or is 40mg Prozac stronger ? Thnx

Hi IV recently gone from 40mg fluoxetine a day to starting duloxetine 30mg. Is duloxetine stronger than fluoxetine ? Or is 40mg Prozac stronger ? Thnx

Responses vary: Each individual patient responds differently to each medication, so there is no way to directly compare fluoxetine and duloxetine or to predict how you will respond to a particular dose. In general, dosing of fluoxetine ranges between 20-60mg, while duloxetine is typically dosed between 30 and 60mg. ...Read more

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What are the differences between Prozac and cymbalta (duloxetine)?

What are the differences between Prozac and cymbalta (duloxetine)?

Prozac (fluoxetine) lasts longer: Prozac primarily blocks serotonin reuptake. Cymbalta (duloxetine) blocks norepinephrine & serotonin reuptake. Prozac lasts up to 2 wks in your system after the last dose. Cymbalta (duloxetine) also is used to treat pain & depression. Prozac can help for some anxiety disorders, bulimia & depression. It has variable efficacy in borderline personality disorder. ...Read more

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Is there a way to go off cymbalta (duloxetine) by just switching completely over to Prozac the first day and continuing with prozac?

Is there a way to go off cymbalta (duloxetine) by just switching completely over to Prozac the first day and continuing with prozac?

To avoid: Ssri discontinuation symptoms while making the change - a cross titration could be useful. In other words, reducing the dose of one while increasing the dose of the other. And doing this progressively until you are off the first medication and you get to the target dose of the second medication. ...Read more

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I'm switching from cymbalta (duloxetine) to Prozac so i can get off do I really have to take Prozac before i can go off it as we'll. Just using Prozac as a halfway?

Check game plan.: Everyone who is being tapered from Cymbalta (duloxetine) does not have to hake prozac. However, there may be good reasons why your doctor wants to switch you to this medication . It is possible that this medications will work better for you. It is always best to talk it over with the prescribing doctor so you understand the game plan. ...Read more

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After i switch to Prozac after a week of transition from cymbalta (duloxetine) would i be able to wean off Prozac without issues or keep take for a month then wean?

Work w/your doctor: I don't know what your psychiatrist has in mind for your treatment, so it's not appropriate for me to guess about that. You really need to discuss this withhim or her. However, Prozac (fluoxetine) is a very long-acting medication and is sometimes used to taper from other ssri antidepressants. Smaller increments of Prozac (fluoxetine) are also available, and can be used in tapering if needed. ...Read more

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I've been taking Prozac 60mg for a few months now. With no improvement, my doc switched me to cymbalta (duloxetine) 60mg. Can i stop the Prozac cold and switch over?

Consult Doc: Prozac (fluoxetine) is a long acting medication and stays in your system for a long time and usually does not need tapering down of dose, however you seem to be on a higher dose, tapering to a smaller dose should before discontinuing. Your doc is the best person to decide that. ...Read more

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Are fluoxetine and gabapentin effective treatments for fibromyalgia?

Are fluoxetine and gabapentin effective treatments for fibromyalgia?

They can be: Fluoxetine is an anti-anxiety, anti-depressant medication that may help mood and anxiety problems that can be common in fibromyalgia. Gabapentin is an anti-convulsant medication that can be used off-label to improve neuropathic pain, which is common in fibromyalgia. So in some patients, together these medications can improve different problems that occur in fibromyalgia. ...Read more

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Am i at risk of serotonin syndrome i'm switching to to Prozac from cymbalta (duloxetine). One day Prozac one day cymbalta (duloxetine) for a week. Then Prozac all for a month?

Am i at risk of serotonin syndrome i'm switching to to Prozac from cymbalta (duloxetine). One day Prozac one day cymbalta (duloxetine) for a week. Then Prozac all for a month?

Don't know the: Doses. It sounds like this is not a cross titration but rather doubling up the medications for a week? There are some people who develop serotonin syndrome even at low medication doses. However, for most people - the higher amounts of serotonin are the issue. Without knowing doses can't really comment. ...Read more

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Do wellbutrin, Prozac and cymbalta (duloxetine) cause weight gain?

Do wellbutrin, Prozac and cymbalta (duloxetine) cause weight gain?

Sometimes: Wellbutrin does not generally cause weight gain (and is often used specifically because it doesn't), although rarely it might cause weight gain. Prozac is somewhat more likely than wellbutrin to cause weight gain, but again generally does not. Cymbalta (duloxetine) is probably about as likely as Prozac to cause weight gain, but again generally does not cause significant weight gain. ...Read more

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My psychiatrist selected Prozac for ocd and off of 30 Cymbalta (duloxetine)...1 week 20 now 40 ..a little restlesst claims this is normal til Prozac in system ok?

Yes.: Some ppl can get akathisia -- limb restlessness with higher doses of SSRI meds. If the restlessness worsens tell your doc. May be evolving akathisia. Remedy may be low dose Benadryl (diphenhydramine) 25mg twice a day. Watch out for sedation and confusion from benadryl (diphenhydramine). ...Read more

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How does Prozac (fluoxetine) reduce pain? Helps with my back pain/my neuropathy in my foot. Doesn't seem to help all pain (fibromyalgia = not as much help)

Chemicals: Prozac (fluoxetine) is approved for chronic headaches but otherwise lacks indication for chronic pain such as neuropathy. It may help improving the pain by improving underlying depression, even if it was subtle or undiagnosed. Improvements in depression are linked to heightened pain tolerance. ...Read more

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Anti-depressant meds I have been on anti-depressants previously. In 2006-2008 i was on wellbrutin, then prozac, then cymbalta (duloxetine). I am depressed again - would the last med (cymbalta (duloxetine)) i took be the best choice at this time.

Anti-depressant meds I have been on anti-depressants previously.  In 2006-2008 i was on wellbrutin, then prozac, then cymbalta (duloxetine). I am depressed again - would the last med (cymbalta (duloxetine)) i took be the best choice at this time.

Whichever one: Worked the best for you is what i would recommend. Prozac (fluoxetine) is the only antidepressant with a study on trying it again after it stopped working. There was a 90% chance of it working the second time around. We have no comparable data on the others. ...Read more

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Dr. Laurence Badgley
1,354 doctors shared insights

Fibromyalgia (Definition)

Widespread pain and tenderness on palpation of specific muscle points, associated with variety of other symptoms that include fatigue, sleep disturbances, depression, ...Read more


Dr. Alan Ali
761 doctors shared insights

Prozac (Definition)

Prozac is a serotonin reuptake blocker which is a kind of ...Read more