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Doctor insights on: Has Anyone Tried Fluoxetine Or Duloxetine For Fibromyalgia

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Has anyone tried fluoxetine or duloxetine for fibromyalgia?

Has anyone tried fluoxetine or duloxetine for fibromyalgia?

Duloxetine for Fibro: There are now three drugs that have been approved by the fda for the treatment of fibromyalgia-duloxetine (cymbalta), lyrica (pregabalin), (pregabalin) and milnacipran (savella). Studies has shown no difference in effectiveness between savella and cymbalta. We usually use one of the two along with lyrica (pregabalin). This combination has been the first medications to provide real benefit to fibromyalgia patients in years. ...Read more

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Dr. Heidi Fowler
1,016 doctors shared insights

Fluoxetine (Definition)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better ...Read more


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Hi! I'm switching from a daily dose of 30mg Duloxetine to 20mg Fluoxetine. Do I need to taper off Duloxetine, or can I switch immediately?

Hi! I'm switching from a daily dose of 30mg Duloxetine to 20mg Fluoxetine. Do I need to taper off Duloxetine, or can I switch immediately?

Switching Medication: I understand your need for improvement in Depression and Anxiety. Duloxetine (Cymbalta) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Fluoxetine is a SSRI medication. See Psychiatrist and inform about side effects of Duloxetine, and discuss risks of sudden withdrawal from it; discuss benefits and side effects of Fluoxetine; and Therapy for stresses in life. ...Read more

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What is the chemical difference between duloxetine and fluoxetine?

What is the chemical difference between duloxetine and fluoxetine?

Differences: These two medicines share similarities, but they have different chemical structures, leading to different actions on the nervous system. Fluoxetine almost exclusively acts on the neurotransmitter serotonin, while duloxetine has a mixed action on both serotonin and norepinephrine. This difference will sometimes result in a person doing better with one medicine versus the other. ...Read more

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What is the difference between fluoxetine and duloxetine in effects on weight?

What is the difference between fluoxetine and duloxetine in effects on weight?

Varied: Fluoxetine can initially decrease appetite, but has been associated with weight gain with prolonged use. Duloxetine can also cause initial weight loss and is less likely to cause weight gain over time. ...Read more

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Hi IV recently gone from 40mg fluoxetine a day to starting duloxetine 30mg. Is duloxetine stronger than fluoxetine ? Or is 40mg Prozac stronger ? Thnx

Hi IV recently gone from 40mg fluoxetine a day to starting duloxetine 30mg. Is duloxetine stronger than fluoxetine ? Or is 40mg Prozac stronger ? Thnx

Responses vary: Each individual patient responds differently to each medication, so there is no way to directly compare fluoxetine and duloxetine or to predict how you will respond to a particular dose. In general, dosing of fluoxetine ranges between 20-60mg, while duloxetine is typically dosed between 30 and 60mg. ...Read more

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What are the differences between Prozac and cymbalta (duloxetine)?

What are the differences between Prozac and cymbalta (duloxetine)?

Prozac (fluoxetine) lasts longer: Prozac primarily blocks serotonin reuptake. Cymbalta (duloxetine) blocks norepinephrine & serotonin reuptake. Prozac lasts up to 2 wks in your system after the last dose. Cymbalta (duloxetine) also is used to treat pain & depression. Prozac can help for some anxiety disorders, bulimia & depression. It has variable efficacy in borderline personality disorder. ...Read more

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Is there a way to go off cymbalta (duloxetine) by just switching completely over to Prozac the first day and continuing with prozac?

Is there a way to go off cymbalta (duloxetine) by just switching completely over to Prozac the first day and continuing with prozac?

To avoid: Ssri discontinuation symptoms while making the change - a cross titration could be useful. In other words, reducing the dose of one while increasing the dose of the other. And doing this progressively until you are off the first medication and you get to the target dose of the second medication. ...Read more

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I'm switching from cymbalta (duloxetine) to Prozac so i can get off do I really have to take Prozac before i can go off it as we'll. Just using Prozac as a halfway?

Check game plan.: Everyone who is being tapered from Cymbalta (duloxetine) does not have to hake prozac. However, there may be good reasons why your doctor wants to switch you to this medication . It is possible that this medications will work better for you. It is always best to talk it over with the prescribing doctor so you understand the game plan. ...Read more

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After i switch to Prozac after a week of transition from cymbalta (duloxetine) would i be able to wean off Prozac without issues or keep take for a month then wean?

Work w/your doctor: I don't know what your psychiatrist has in mind for your treatment, so it's not appropriate for me to guess about that. You really need to discuss this withhim or her. However, Prozac (fluoxetine) is a very long-acting medication and is sometimes used to taper from other ssri antidepressants. Smaller increments of Prozac (fluoxetine) are also available, and can be used in tapering if needed. ...Read more

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Dr. Jay Rosenfeld
1,329 doctors shared insights

Fibromyalgia (Definition)

Widespread pain and tenderness on palpation of specific muscle points, associated with variety of other symptoms that include fatigue, sleep disturbances, depression, anxiety, ...Read more


Dr. Alan Ali
737 doctors shared insights

Prozac (Definition)

Prozac is a serotonin reuptake blocker which is a kind of ...Read more