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Doctor insights on: Handling Angelman Syndrome Condition

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Please tell me if angelman syndrome is inherited or a disorder?

Please tell me if angelman syndrome is inherited or a disorder?

Sometimes: Some cases are due to a mutation carried by the mother. Most are due to spontaneous mutations or epigenetic events in the fertilized egg. So, the risk of Angelman may be inherited, but the disease may be genetic or due to epigenetic factors. It is one of the most complex genetic mechanisms yet discovered, and a clinical geneticist must analyze whether other family members are at up to 50% risk ...Read more

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Dr. Neeta Jain
67 doctors shared insights

Angelman Syndrome (Definition)

Angelman syndrome is a genetic disorder that causes mental retardation, movement problems, and seizures. Children with Angelman syndrome typically laugh a lot and ...Read more


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How is angelman syndrome treated? and how is this disorder diagnosed?

How is angelman syndrome treated? and  how is this disorder diagnosed?

Dx 90% lab, 10% PE: A clinical geneticist can make a diagnosis by observing the combination of unusual behavioral features and pattern of developmental delay, usually by 2 years of age. 90% confirmed by convoluted genetic testing, 10% by clinical presentation alone. Treatment includes the full range of therapies for developmental delay, especially speech therapy initially concentrating on nonverbal communication. ...Read more

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Hello docs, is angelman syndrome inherited or a disorder?

Hello docs, is angelman syndrome inherited or a disorder?

Most of the time not: Angelman syndrome, while it is a genetic condition, is rarely inherited and thus the risk of it happening again in other children of the same parents is very low, . ...Read more

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Angelman syndrome information needed?

Angelman: The answer can be found here: http://www.Ninds.Nih.Gov/disorders/angelman/angelman.Htm. ...Read more

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What is the population affected by angelman syndrome?

What is the population affected by angelman syndrome?

Angelman s.: Newborns with genetic abnormality involving chromosome #15q ( partial deletion of short piece of that chromosome). ...Read more

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What is a way to detect a carrier of angelman syndrome?

What is a way to detect a carrier of angelman syndrome?

Angelman Syndrome: Most cases of Angelman syndrome are not inherited, particularly those caused by a deletion in the maternal chromosome 15. These genetic changes occur as random events during the formation of reproductive cells (eggs and sperm) or in early embryonic development. Affected people typically have no history of the disorder in their families. ...Read more

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Is angelman syndrome dominant or recessive?

Is angelman syndrome dominant or recessive?

Neither: Angelman's syndrome doesn't follow simple mendelian genetics. Rather, it's due to de novo single genetic mutations, translocational errors, chromosomal abnormalities, or more commonly epi-genetic mutations such as changes in dna methylation. ...Read more

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What are signs and symptoms of angelman syndrome?

What are signs and symptoms of angelman syndrome?

ANGELMAN SYNDROME: Angelman syndrome is a complex genetic disorder that affects the nervous system. Characteristic features of this condition include delayed development, intellectual disability, severe speech impairment, and problems with movement and balance. Most affected children also have recurrent seizures and a small head size. Delayed development becomes noticeable by the age of 6 and other S/S appear. ...Read more

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What are the signs and symptoms of angelman syndrome?

What are the signs and symptoms of angelman syndrome?

Angelman: Happy kids, pleasant disposition, developmental and speech delay, seizures and ataxia(uncoordinated)walking. ...Read more