Doctor insights on:
Fatigable weakness: Myasthenia gravis is an autoimmune disease that disrupts the neuromuscular junction, so that when motor nerves fire the muscle fibers do not reliably contract. It manifests as a "fatigable weakness" (one that gets worse with sustained effort) that can involve the limbs, the cranial nerves (hoarseness, double vision, difficulty swallowing), or, in some dangerous cases, muscles of breathing. ...Read moreSee 2 more doctor answers
Immune disorder: Which affects to neuromuscular junction connections of nerve to muscle. Associated with progressive weakness on exertion, and can be associated with double vision, problems breathing, and swallowing. Treatment in past involved, steroids, immune agents, and meds that affect the neurotransmitter acetylcholine. ...Read more
Wide range of people: Conditions that increase your risk for developing myasthenia include: autoimmune disease (thyroid disease, lupus, rheumatoid, type I diabetes), a tumor called a thymoma, and exposure to certain medications (most famously an immunosuppressant and chelating agent called penicillamine). ...Read more
In most cases, myasthenia gravis is not inherited and occurs in people with no history of the disorder in their family.
About 3 to 5 percent of affected individuals have other family members with myasthenia gravis or other autoimmune disorders, but the inheritance pattern is unknown.
For more info please review the following:
http://www. Myasthenia. Org/whatismg/faqs. Aspx. ...Read more
Usually very serious: Myasthenia gravis is typically seen in the young and the elderly. In the latter group, they typically have ocular mg, that is there symptoms are confined to the eye muscles. In the young, symptoms include muscle weakness, breathing difficulties, swallowing difficulties, visual problems (double vision, droopy eye lids), problems chewing. Symptoms worsen during the day. If not treated, it can be fatal. ...Read moreSee 2 more doctor answers
Wide range of people: Myasthenia has been reported in people of all age groups, but it tends to be more common in people aged 50-70 or in women under 40. Conditions that increase your risk for developing myasthenia include: autoimmune disease (thyroid disease, lupus, rheumatoid, type I diabetes), thymoma, and exposure to certain medications (most famously an immunosuppressant and chelating agent called penicillamine). ...Read more
Women>men: Before the age of 40 mg is 3x more common in women, but at older ages both sexes are equally affected. Familial cases are rare. Congenital mg in children are rarely encountered. Their mothers are asymptomatic, and the condition is often familial. Limb weakness is present but eye movement weakness is the dominant sign. There are also neonatal forms characterized by weak suck, and juvenile forms. ...Read moreSee 1 more doctor answer
Fatigable weakness: The hallmark of myasthenia is "fatigable weakness", meaning that muscles get weaker with prolonged use. Typical symptoms include double vision, droopy eyelids, or weakness of the limbs, all worse with activity or at the end of the day. It can also cause difficulty speaking, swallowing, and breathing, which can be extremely dangerous. ...Read more
Weakness: Characteristically, it is a disease affecting nerve and muscle connections, and may initially present with double vision, drooping of eyelids, and weakness involving arms and legs. Repetitive usage of muscles can result in increased weakness and increased lid drooping and double vision. If the problem intensifies, difficulty with breathing can occur, and this may become critical. ...Read more
Weakness: An immunological disorder of the neuromuscular junction, affecting efficiency of nerve muscle impulses, by making acetylcholine surge ineffective. Repetitive contractions are increasingly weak. May affect eye muscles predominantly, with double vision, and lid drooping, but can also affect arms and legs, and ability to breathe. Thymectomy may help, meds also useful. ...Read more