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Doctor insights on: Going Off Methotrexate

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Was on humira (adalimumab) weekly&psoriasis came back. Now on enbrel&25mg methotraxte.Do u think psorias will clear?Y did humira (adalimumab) stop working?Stress overpower it?

Was on humira (adalimumab) weekly&psoriasis came back. Now on enbrel&25mg methotraxte.Do u think psorias will clear?Y did humira (adalimumab) stop working?Stress overpower it?

Both work: It's your these medicines are effective. The reason medication stop working may depend on many factors. Sometimes the body develops resistance to a medication that is working fine. The resistance can occur because of antibodies against the drug. It can also occur because the mechanism of the disease of the illness can change differently at the molecular level. You doctor can better answer this. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Dr thought I had hives, put on prednisone 50mg 9 days now, then taper off. Turns out its bed bug bites. Can I stop taking the prednisone now or taper?

Dr thought I had hives, put on prednisone 50mg 9 days now, then taper off. Turns out its bed bug bites. Can I stop taking the prednisone now or taper?

Here is the issue: You are under another doctor's care. Once I direct you how to discontinue this medication, I have now interfered with the care you are receiving. I know what the answer is, but this site is for general medical education. I believe it would not be ethical for me to give you information, that would enable your medical provider to be by-passed. ...Read more

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Why does one have to wean off methotrexate?

Why does one have to wean off methotrexate?

Weaning is not: Necessary. The body takes 2 & 1/2 months to eliminate MTX. Stopping is enough. Weaning makes little sense! ...Read more

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Would it be ok going out of state day after having 2nd remicade (infliximab) infusion?

Would it be ok going out of state day after having 2nd remicade (infliximab) infusion?

Remicade (infliximab): You can go out of town in developed countries(US),but would take a thermometer, for temperature.. if you do get ill, diarrhea, pains,fever,cough, during your trip seek attention within 24 hours at an urgent care/ER and always have your doctor's number with you when traveling. Immunosuppressed should best avoid swimming in lakes, oceans (oxymetazoline) (bacteria), dusty/desert areas(mold),sleeping on the ground ...Read more

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I am on 20mg Methotrexate for Psoriasis for the last 10 years.Can I give it up without weaning off without side effects. Thanks?

I am on 20mg Methotrexate for Psoriasis for the last 10 years.Can I give it up without weaning off without side effects. Thanks?

Talk to derm: It is best for you to work with your doctor on getting your off of methotrexate and discuss potential options should the psoriasis recur. ...Read more

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How should I taper off Donezepil 10mg?

How should I taper off Donezepil 10mg?

Consult: Please consult your physician who knows you best. ...Read more

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Im 8weeks off off Suboxone and on naltrexone still no energy and terrible RLS .Just started lyrica (pregabalin) &doc is slowly raising dose will this ever end?

Im 8weeks off off Suboxone and on naltrexone still no energy and terrible RLS .Just started lyrica (pregabalin) &doc is slowly raising dose will this ever end?

Ask for specific : Treatment for rls. Narcotics such as suboxone do a great job blocking rls. Naltrexone on the other hand can have the opposite effect. Your doctor should order a ferritin level to make sure that your total iron body stores are not diminished. I would not be surprised if you also have periodic limb movements of sleep which often accompanies rls. This can cause a great disturbance in sleep continuity and daytime fatigue and sleepiness. The treatment is the same as for rls. ...Read more

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Cousin went off of anxiety meds and gained 15lbs in the weaning process. I start weaning off Lexapro (escitalopram) July 10th. Will this happen to me also?

Cousin went off of anxiety meds and gained 15lbs in the weaning process. I start weaning off Lexapro (escitalopram) July 10th. Will this happen to me also?

Lexapro (escitalopram): Not necessarily because no two people respond the same way. But if worried about weight then would be proactive by eating balanced healthy meals and incorporating a regular exercise regimen. ...Read more

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Hands broke out from generic plaquenil (hydroxychloroquine). Was put on prednisone 5mg dr says he will ween me off pred. Put me on name brand plaquenil (hydroxychloroquine). Is that normal?

Hands broke out from generic plaquenil (hydroxychloroquine). Was put on prednisone 5mg dr says he will ween me off pred. Put me on name brand plaquenil (hydroxychloroquine). Is that normal?

Do not take it: Allergic reactions to generic meds almost always means you are allergic to the brand name as well. In addition, the next reaction is likely to be much more severe than the initial one. Do not take it. This is a rheumatologist telling you. ...Read more

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I've been on Effexor (venlafaxine) for almost ten yrs.Seems like its not helping anymore? Should I wean off nd go on something else like a ssri?

I've been on Effexor (venlafaxine) for almost ten yrs.Seems like its not helping anymore? Should I wean off nd go on something else like a ssri?

DO NOT DO ANYTHING: Without talking wtih your doctor first! you may need a change, or an augmentation strategy, but you need to be working with your doctor! ...Read more

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What to expect when first starting off on clonazepam?

What to expect when first starting off on clonazepam?

Depends on dose: and what you are being treated for. The approved indication for Clonazepam is for treatment of seizures, and then I would expect a reduction in your number and severity of seizures. If treatment for anxiety, that should gradually lessen. You may feel tired or sleepy, and may experience reduced concentration and focus. You should not drive until you see how it effects you, and exercise caution. ...Read more

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How to taper off taking 10 mg Escitalopram. Been on it 2 years.

How to taper off taking  10 mg Escitalopram. Been on it 2 years.

Slow taper: First of all, are you sure you want to go off it? Is that what the doctor ordered? If yes, you can do a slow taper by reducing to 5mg for a week, then take it alternate days for a further 5 days then stop. Keep an eye out for how you feel over the next few weeks to months after stopping. ...Read more

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Off celexa (citalopram) for 45days now. Was on it for 6months. Didn't stop cold turkey. Tamp slowly. Still getting neaseous & shocks. When will this stop?

Off celexa (citalopram) for 45days now. Was on it for 6months. Didn't stop cold turkey. Tamp slowly.  Still getting neaseous & shocks. When will this stop?

Usually Two Weeks: Two weeks would be a normal maximum time for withdrawal. Symptoms you are experiencing now are more likely from an underlying condition. ...Read more

Dr. Robert Lowe
341 doctors shared insights

Rheumatrex (Definition)

Rheumatrex ...Read more