Doctor insights on:
Gnrh Stimulator Medication
Can you tell me for some women, secretion of gnrh is inadequate, they're consider sterile and are treated drugs that mimic it?
GnRH secretion: Some women (and men) fail to secrete GnRH from the hypothalamus (part of the brain). Therefore, there is no signal to the pituitary to make reproductive hormones (FSH and LH). In Europe, Factrel is available via an automated pump. In the US, we give fertility pts FSH and hCG to cause ovulation. For those women not trying to conceive, estrogen and progesterone hormone replacement is given. ...Read more
Complicated: Gnrh stands for gonadotropin releasing hornone. It's a neurohormone produced in the hypothalamus (part of the brain). Its release controls the production/release of 2 pituitary hormones called luteinizing hormone (lh) and follicle stimulating hormone (fsh) which in turn regulate and affect your ovary/menstrual periods or in men sperm and testosterone production. ...Read moreSee 1 more doctor answer
Insulin: GnRH is stimulated by an increase in insulin (as can be seen in PCOS). An increase in prolactin causes a decrease in GnRH. GnRH is low in early childhood, then is activated in puberty, and has a pulsatile release for normal reproductive function. What exactly initiates puberty is not completely known with biological and environmental factors playing a role. ...Read more
Normal: I am not sure what you are asking, but GNRH is a hormone produced by the hypothalamus. It is made in a pulsatile manner normally. This acts on the pituitary gland to cause the release of LH, also in a pulsatile manner. Taking large amounts of GNRH analogs (such as Lupron) initially causes release of LH, but then suppresses further release (thereby turning off testosterone or estrogen production) ...Read more
GnRH hormones: While normally gnrh stimulates sex hormones, it achieves this only when it is secreted in bursts by the hypothalamus. When given in injections, it circulates continuously and it suppresses the hormones that in turn stimulate the ovary in women and the testes in men. As a consequence, there is a lack of sex hormones (estradiol in women, testosterone in men, leading to bone loss as in menopause. ...Read moreSee 1 more doctor answer
FSH,LH: Gnrh stimulates follicle stimulating hormone & luteinizing hormone which stimulates the ovary to produce estrogen and Progesterone which stimulates ovulation which causes increased Progesterone which causes secretory endometrium which prepares the endometrium to allow implantation of a fertilized egg. If no fertilized egg, Progesterone falls which stimulates gnrh to again rise & the cycle repeats. ...Read more
Yes: Testosterone (from the testicles) and gnrh (from the hypothalamus) are connected by a feedback mechanism much like the thermostat in one's house. When testosterone levels rise for whatever reason, the hypothalamus decreases its release of gnrh to help bring t back to normal levels and vice versa. ...Read moreSee 1 more doctor answer
Unlikely: Generally no, not pain unless you mean pain at the injection site. ...Read more
Good question: Gnrh would seem by its name to help release gonadotropin. And if used in a certain fashion it could cause the release of gonadotropins (lh, fsh). However when given in a shot and having a sustained effect on the pituitary, it actually suppresses the release of lh and fsh. And this aspect of the medication can be used to help in many situations. ...Read more
I was told that I had a slight decrease in my bone density while on gnrh-a. Can you explain this?
Why do FSH levels rise around day 14 of the cycle? Is it just because of the higher GnRH that cause the LH surge?
You asked...: FSH rises because 1) it induces expression of its own receptor and 2) it stimulates E2 production, which also induces expression of more FSH receptors. GnRH is not "higher" or lower, GnRH is pulsatile: the frequency of the pulses is as important (or more) than the pulse amplitude. If this unclear, I suggest consulting an endocrinology text, there is no short version. ...Read moreSee 1 more doctor answer
Temporary Relief?: First, one needs to be sure of the diagnosis. It is a surgical diagnosis. Second, these medications create a temporary menopause with numerous side effects including bone loss. Add back hormones may help. That stated, these medications allow for the shrinking of the lesions but they are not removed. Within three months of stopping the medication, the lesions are back with symptoms to follow. ...Read moreSee 1 more doctor answer