Doctor insights on:
Gnrh Stimulator Medication
Can you tell me for some women, secretion of gnrh is inadequate, they're consider sterile and are treated drugs that mimic it?
GnRH secretion: Some women (and men) fail to secrete GnRH from the hypothalamus (part of the brain). Therefore, there is no signal to the pituitary to make reproductive hormones (FSH and LH). In Europe, Factrel is available via an automated pump. In the US, we give fertility pts FSH and hCG to cause ovulation. For those women not trying to conceive, estrogen and progesterone hormone replacement is given. ...Read more
Complicated: Gnrh stands for gonadotropin releasing hornone. It's a neurohormone produced in the hypothalamus (part of the brain). Its release controls the production/release of 2 pituitary hormones called luteinizing hormone (lh) and follicle stimulating hormone (fsh) which in turn regulate and affect your ovary/menstrual periods or in men sperm and testosterone production. ...Read more
Insulin: GnRH is stimulated by an increase in insulin (as can be seen in PCOS). An increase in prolactin causes a decrease in GnRH. GnRH is low in early childhood, then is activated in puberty, and has a pulsatile release for normal reproductive function. What exactly initiates puberty is not completely known with biological and environmental factors playing a role. ...Read more
Normal: I am not sure what you are asking, but GNRH is a hormone produced by the hypothalamus. It is made in a pulsatile manner normally. This acts on the pituitary gland to cause the release of LH, also in a pulsatile manner. Taking large amounts of GNRH analogs (such as Lupron) initially causes release of LH, but then suppresses further release (thereby turning off testosterone or estrogen production) ...Read more
Different effects: Continuous secretion of gnrh suppresses production of FSH & lh from the pituitary. Pulses of gnrh stimulate production of FSH & lh from the pituitary. ...Read more
GnRH hormones: While normally gnrh stimulates sex hormones, it achieves this only when it is secreted in bursts by the hypothalamus. When given in injections, it circulates continuously and it suppresses the hormones that in turn stimulate the ovary in women and the testes in men. As a consequence, there is a lack of sex hormones (estradiol in women, testosterone in men, leading to bone loss as in menopause. ...Read more
FSH, LH: Gnrh stimulates follicle stimulating hormone & luteinizing hormone which stimulates the ovary to produce estrogen and Progesterone which stimulates ovulation which causes increased Progesterone which causes secretory endometrium which prepares the endometrium to allow implantation of a fertilized egg. If no fertilized egg, Progesterone falls which stimulates gnrh to again rise & the cycle repeats. ...Read more
Yes: Testosterone (from the testicles) and gnrh (from the hypothalamus) are connected by a feedback mechanism much like the thermostat in one's house. When testosterone levels rise for whatever reason, the hypothalamus decreases its release of gnrh to help bring t back to normal levels and vice versa. ...Read more
Unlikely: Generally no, not pain unless you mean pain at the injection site. ...Read more
Good question: Gnrh would seem by its name to help release gonadotropin. And if used in a certain fashion it could cause the release of gonadotropins (lh, fsh). However when given in a shot and having a sustained effect on the pituitary, it actually suppresses the release of lh and fsh. And this aspect of the medication can be used to help in many situations. ...Read more
GnRH: Fsh and lh.Get a more detailed answer ›
I was told that I had a slight decrease in my bone density while on gnrh-a. Can you explain this?
Why do FSH levels rise around day 14 of the cycle? Is it just because of the higher GnRH that cause the LH surge?
You asked...: FSH rises because 1) it induces expression of its own receptor and 2) it stimulates E2 production, which also induces expression of more FSH receptors. GnRH is not "higher" or lower, GnRH is pulsatile: the frequency of the pulses is as important (or more) than the pulse amplitude. If this unclear, I suggest consulting an endocrinology text, there is no short version. ...Read more
Temporary Relief?: First, one needs to be sure of the diagnosis. It is a surgical diagnosis. Second, these medications create a temporary menopause with numerous side effects including bone loss. Add back hormones may help. That stated, these medications allow for the shrinking of the lesions but they are not removed. Within three months of stopping the medication, the lesions are back with symptoms to follow. ...Read more
Any doctor prescribe gnrh in ny? Can someone help me to locate a obgyn in ny who prescribe gnrh in ny?
See the right kind: Any doctor can prescribe gnrh but you need to see the right type of doctor to be sure you are being treated appropriately. Pure gnrh is used to help women ovulate who have a very specific hormone imbalance. Very few people in the field of reproductive medicine still use this. If you are interested in a gnrh agonist such as Lupron (leuprolide) most gyns use it commonly. ...Read more
Had chocolate cyst laparoscopy done 3 months back, was on gnrh hormoneinjection. When can I have my periods as it is already 1 1/2 months now
Endometriosis: Sounds like the periods should be returning soon, like within 2 weeks. ...Read more
Had open myomectomy 1 month ago & 15fibroids were removed. 3 months GnRH before surgery. When to expect my menstruation?
6 to 8 weeks: Sic to eight weeks post operatively.Get a more detailed answer ›
A lot: They work in different ways and for different indications. ...Read more
Adult-onset hypogonadotropic hypogonadism--how does gnrh therapy differ from normal testosterone therapy? Which therapy is best for 42 year old male?
Only for children: Gnrh is by injection, vey expensive, and only for children -- it wouldn't be appropriate or effective or prescribed for you. Stick with transdermal testosterone. Hopefully, you've had your undescended testicle fixed early in childhood, as they can become cancerous of not brought down surgically early in life. If it's still undescended, see you doctor soon. ...Read more
I recently had the gnrh injection prior to surgery to remove fibroids. Is it normal to have a slight bleed with severe backache and abdominal pain?
WHAT DID THE DOC SAY: Who gave u the injection, u should be asking that doc before u ask here- that is just common sense, your doc should have expalined to u that for the 1st 2 weeks it can make your symptoms worse as u get a hormone surg before it shuts them down, your doc should have expalined that to u but u should call that doc now as the doc may want to see u or give u pain med relief. ...Read more
MAO meds: Don't worry about any OTC supplements or meds. MAO meds are very few & hardly used now. MAOIs were the first antidepressants in clinical use. They were discovered in 1952. These meds irreversibly block monoamine oxidase, the enzyme responsible for metabolizing neurotransmitters like serotonin. They include tranylcypromine, phenelzine, & selegiline. These meds interact w/ many others & foods ...Read more
VNS: Is a wonderful device used to treat refractory seizures and depression. About the size of half an Oreo Cookie it is placed under the skin by a skilled surgeon. A thin wire sends a tiny current intermittently to the brain by way of the left Vagus Nerve in the neck. My patients who are lucky enough to have one report overwhelmingly a vast improvement in their lives. They are made in Houston Tx ...Read more
Best for leg pain: Spinal cord stimulation can be very effective for chronic intractable extremity pain but is not as effective for back pain. Temporary electrodes are initially inserted with an external pulse generator and if the leg or arm pain is adequately controlled, a permanent system is then implanted. ...Read more