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Doctor insights on: Gnrh Gene And Addiction

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Do med assisted therapy drugs like Suboxone & Methadone continue to hinder dopamine production in the opiate abused brain?

Do med assisted therapy drugs like Suboxone & Methadone continue to hinder dopamine production in the opiate abused brain?

Still studied: Currently the thought is that although suboxone initially increases dopamine ultimately it blocks dopamine activity. Methadone may stimulate dopamine synthesis but recent brain studies do not see effect in the brain Stimulents are very potent dopamineric medications. ...Read more

Dr. Vasu Brown
612 doctors shared insights

Addiction (Definition)

Addiction is a primary, chronic disease of brain reward, motivation, memory, and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by substance use and other behaviors. A person affected by addiction will be unable to consistently Abstain from use, will have Impaired Behavioral control, will have Craving or increased "hunger" for drugs or rewarding experiences, will have a Dysfunctional Emotional response, and will show diminished recognition of significant problems with their own ...Read more


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How are genetics inovlved with nicotine addiction?

How are genetics inovlved with nicotine addiction?

Some involvement: There are a group of genes that have been shown to predispose people to be more likely to develop nicotine addiction if they choose to smoke, and the absence of all these genes appears to be more likely in those who are able to "chip" occasionally - smoke a cigarette here and there "socially," - and yet not get addicted. For most people, 7 cigarettes in life will predict tobacco dependency. ...Read more

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With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter , DNA mutation (mthfr, a1at ...) methylation etc.

Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients. ...Read more

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Testosterone replacement increases dopamine? Potential for tolerance and dependence?

Testosterone replacement increases dopamine? Potential for tolerance and dependence?

Testosterone: Makes us feel good but do not take unless your blood level is low. If you do not need it, your ownnproduction of testosterone drops and then you are dependent on it. ...Read more

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Does excercise help with repairing blocked dopamine receptors(due to addiction)?

Does excercise help with repairing blocked dopamine receptors(due to addiction)?

Yes: Exercise helps increase dopamine levels. Exercise benefits your mental and physical health in many ways! Go for a natural high with exercise. Check first with your primary care physician before you begin an exercise program. ...Read more

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Why is the alpha-5 nicotinic receptor linked to nicotine addiction?

Why is the alpha-5 nicotinic receptor linked to nicotine addiction?

In Bronchial Epithel: Very interesting question, regarding nicotine related damage to bronchial epithelia cell BEC. Nic decreased the relative numbers of alpha 5-containing nAChRs, suggesting a role for receptor desensitization. This was demonstrated by biphasic increase in the concentrations of intracellular calcium ([Ca++]i) in response to activation of the channel by Nicotine and damage to delicate cell lining. ...Read more

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How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?

How do dopamine antagonist help opioid nausea if opioid nause is mediated through opioid receptors and not dopamine?

interrelated: All receptor systems are interrelated and interact with each other. Whatever induces nausea, the reaction is triggered by dopaminergic pathways in a part of the brain called the chemoreceptor trigger zone. Most anti-emetics work by antagonizing dopamine. The combination of opioids and antinausea medications is quite common, both for synergism and to reduce nausea. ...Read more

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Why we doctor's so afraid of marijuana? An entire new class of medication with risk:benefit and LD50 superior to (?)all drugs. Politics > Science?

Why we doctor's so afraid of marijuana? An entire new class of medication with risk:benefit and LD50 superior to (?)all drugs. Politics > Science?

Both: While Marijuana is illegal in most states even medical use hence excluding most doctors in prescribing it. In some states it is legal medically and recreational in a few states. It is clear that Marijuana is helpful in anxiety, chronic pain, anorexia in aids and cancer. However this benefits must be weighed against the adverse effects including decreased response and altered cognition ...Read more

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Would medication for alcohol and amphetamine addiction complicate a mini tummy tuck procedure? I'm struggling to overcome alcohol and amphetamine addiction with specialized therapy and counseling. The medications that help me with the withdrawal are cloni

Not a Good Idea: You should not undergo tummy tuck surgery or any other type of elective surgery while in the recovery phase of addictions. Patients should be medically, psychosocially, financially stable prior to proceeding with any type of elective surgery. Best wishes. ...Read more

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How does giving FSH and LH in a fertility drug for women who need IVF help?

How does giving FSH and LH in a fertility drug for women who need IVF help?

Superovulation: Fsh & lh help stimulate egg development in the ovaries. More eggs give you more embryos with better success rates for ivf. ...Read more

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How does imatinib stop the signaling pathway of mutated kit in patients with gist?

How does imatinib stop the signaling pathway of mutated kit in patients with gist?

Inhibits enzyme: The drug fits precisely into a "pocket" in the enzyme encoded by the mutant gene, blocking the enzyme's function. ...Read more

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Why isn't gene therapy used to produce insulin?

Why isn't gene therapy used to produce insulin?

Gene therapy: A good question but no immediate answer. I am confident that within the next 5-10 years there will be major advances to produce insulin in your body. Till then you have to be patient. PS: There may be some ongoing clinical trials in which you could participate. ...Read more

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Fertility: thoughts on frenchscientists discoving link btw use of ovarian stim drugs to a 2.6 fold increase in acute lymphoma inchildren. Chlomid ok?

Fertility: thoughts on frenchscientists discoving link btw use of ovarian stim drugs to a 2.6 fold increase in acute lymphoma inchildren. Chlomid ok?

Clomid (clomiphene) risk: As with everything in medicine, time will tell , more research, etc also, if Clomid (clomiphene) is the way a couple can have a baby the benefit versus risk of other alternatives must be considered as well as costs. Clomid (clomiphene) is one of the most affordable means to stimulate ovulation. ...Read more

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Can l-tyrosine restore dopamine from stimulant usage (medical usage) or does it build your tolerance? Stims r 4 narcolepsy and helps some motivation.

Can l-tyrosine restore dopamine from stimulant usage (medical usage) or does it build your tolerance? Stims r 4 narcolepsy and helps some motivation.

May help: There is little research on this, but l-tyrosine and l-phenyalanine are the precursors (building blocks) of Dopamine & norepinephrine. Theoretically taking these should help us to produce more of these neurotransmitters. This is reasonable to try. For an interesting article on other considerations see http://www.Livestrong.Com/article/322098-how-do-i-boost-dopamine-levels/. ...Read more

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Can psychiatrists prescribe a dopamine agonist like dostinex (cabergoline) to patients with OCD and Anxiety or depression?

Can psychiatrists prescribe a dopamine agonist like dostinex (cabergoline) to patients with OCD and Anxiety or depression?

Anything: Hi. Psychiatrists can prescribe anything the want to that they deem is good for patient care! They're licensed physicians! ...Read more

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How do drug treatments for Alzheimer's disease effect the risk gene apolipoprotein e-e4?

How do drug treatments for Alzheimer's disease effect the risk gene apolipoprotein e-e4?

They don't: Drug treatments for alzheimer's don't affect genes like apo e4. Their intent is to treat the aftermath (the cognitive symptoms of alzheimer's disease itself). Young people with this gene should read dr. David perlmitters new book, "grain brain, " which makes a strong research-based case for gluten and other sugars being linked to alzheimer's and many other problems. http://tinyurl.com/mof6qj8. ...Read more

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Which chromosome defect leads to maple syrup urine disease and can stem cell therapy help?

Which chromosome defect leads to maple syrup urine disease and can stem cell therapy help?

No single chromosome: Mutations in any of the genes that make the enzyme complex needed for normal breakdown of the Amino Acids leucine, isoleucine & valine can be involved. The bckdhb gene on chr. 6 has > 40 possible mutations, as does the bckdha gene on chr.19. The dbt gene on chr 1 has > 30 possible mutations. The dld gene on chr 7 has > 10 mutations that can cause a variant with Lactic Acid build-up. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more