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Doctor insights on: Gnrh Agonists Good Treatments Endometriosis

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Is it true that gnrh agonists are good treatments for endometriosis?

Is it true that gnrh agonists are good treatments for endometriosis?

Temporary Relief?: First, one needs to be sure of the diagnosis. It is a surgical diagnosis. Second, these medications create a temporary menopause with numerous side effects including bone loss. Add back hormones may help. That stated, these medications allow for the shrinking of the lesions but they are not removed. Within three months of stopping the medication, the lesions are back with symptoms to follow. ...Read more

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Agonist (Definition)

An agonist is a chemical that binds to a receptor on a cell and triggers a response by that cell. An agonist usually mimics the action of the naturally occuring substance. An antagonist does just the opposite, blocking the ...Read more


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Is lupron (leuprolide) an effective treatment for endometriosis?

Is lupron (leuprolide) an effective treatment for endometriosis?

Yes: There are many different treatments available for the treatment of endometriosis. Lupron (leuprolide) is a medicine that decrteases estrogen levels and causes endometriosis to shrink away in most woman. Lupron (leuprolide) is used to treat endometriosis pain and endometriosis lesions/endometriomas. It should not be used long term to treat infertility associated with endometriosis-consider other options such as surgery. ...Read more

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What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?

What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca?  Carbo/taxol?  Aromatase inhibitor? Other? Clinical trials?

Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more

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Are there alternative treatments for endometriosis other than the lupron (leuprolide) depot shot?

Are there alternative treatments for endometriosis other than the lupron (leuprolide) depot shot?

Surgery: Removal of endometriosis is an excellent complement to any medical treatment. Aromatase inhibitors and continuous oral contraceptives are also effective in dealing with the symptoms of this disease. ...Read more

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Are progesterone creams good menopause treatments?

Are progesterone creams good menopause treatments?

Not very good: In natural or surgical menopause (removal of both ovaries) the problem is lack of estrogen. Giving estrogen to women who have not had their uterus removed (hysterectomy) increases the risk of uterine cancer, so we give Progesterone or synthetic progestins to protect the uterus. Progesterone as skin cream is not enough to protect the uterus, but can reduce hot flashes and does not prevent bone loss. ...Read more

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Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Are femara (letrozole) and norethindrone used for stage 4 endometriosis?

Not very successfull: No medical treatment has ever been shown to be effective in treating stage IV endo. This stage means that there is deeply invasive endo usually between the rectum and vagina or cervix. Endo nodules are by definition deeper than 5mm, and the hormones can't penetrate well and they don't respond. You need a surgeon very experienced in complex procedures to remove the endo. ...Read more

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Dx w/ endometriosis. Tried multiple bc pills before this diagnosis for ovarian cysts and made bleeding & pain much worse. Will lupron (leuprolide) be similar? Wary of lup

Dx w/ endometriosis. Tried multiple bc pills before this diagnosis for ovarian cysts and made bleeding & pain much worse. Will lupron (leuprolide) be similar? Wary of lup

Different: Lupron (leuprolide) gives you a (temporary) chemical menopause, thus no period. By not stimulating the ovaries the symptoms of endometriosis might improve. Bcp are also commonly used, also put the ovaries "at rest", but different mechanism. ...Read more

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Am faced w/ choices of lupron (leuprolide) or surgery for endometriosis. Unable to tolorate hormone contraceptives and have gilberts syndrome. Which option is best?

Am faced w/ choices of lupron (leuprolide) or surgery for endometriosis. Unable to tolorate hormone contraceptives and have gilberts syndrome. Which option is best?

Choices: Only a doctor who met and examined you can answer this. But, i recommend surgery for patients who are good candidates. Surgery is the only way to make a firm diagnosis, results are generally excellent, and though recurrences happen, they often don't. Lupron (leuprolide) can defintiely help with pain, but: no diagnosis, no fix, expensive, symptoms, and pain comes back when you discontinue. ...Read more

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What are your thoughts on Lupron (leuprolide) treatment for endometriosis pain?

What are your thoughts on Lupron (leuprolide) treatment for endometriosis pain?

It may help: Lupron and Synarel (nafarelin) are both GnRh Agonist drugs that tend to block any progression of existing endometriosis, but may or may not help with the pain. If a 3 to 6 month course of Lupron doesn't alleviate the pain your MD may consider Laparoscopy with ablation as a method + pain medication. ...Read more

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Lupron (leuprolide) depot not helping. What are some alternatives?

Lupron (leuprolide) depot not helping. What are some alternatives?

Assume Pelvic Pain: ? Diagnosis endometriosis and pain. If Lupron (leuprolide) is not helping, the pain is either coming from very severe endo, or from another source. A common associated pain is from the inguinal region and is often associated with endo. Surgery to correct this relieves pain in more than 80%. There are other potential causes of pain that should be evaluated. Seek pelvic pain/endo specialist for more help. ...Read more

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How does lupron (leuprolide) depot work for endometriosis?

How does lupron (leuprolide) depot work for endometriosis?

In the brain: Receptors in the brain get saturated to a that point the pulses of gnrh cannot stimulate the ovarian production of estrogen. ...Read more

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Has anyone used synarel (nafarelin) to treat endometriosis?

Has anyone used synarel (nafarelin) to treat endometriosis?

Long time: Yes, i used it to treat patients occasionally in the early-mid 1990s, as did many other specialists. It was fairly effective but cumbersome to use. I've not used it in many years, and it's overall popularity has faded significantly. ...Read more

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What % of men get heart attacks using lupron (leuprolide) therapy?

What % of men  get heart attacks  using lupron (leuprolide)  therapy?

There is an answer..: Not sure but the risks for each are more or less the same. The incidence of prostate cancer is high in heart disease patients and the incidence of heart disease is high in prostate cancer patients. In my belief, based on oriental medicine, dairy products are the main cause of cancer of the prostate (esp ice cream). Dairy products are the most potent fat raising cholesterol (major heart risk). ...Read more

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How effective are Irinotecan injections for treating colon cancer?

How effective are Irinotecan injections for treating colon cancer?

Pretty good: Usually they're part of a protocol. If I were offered this as adjuvant Rx and it was affordable from my end, I'd probably go ahead if it was offered by an ethical oncologist. I'd quit if it was clearly not helping. ...Read more

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Alternative treatments for pcos good?

Alternative treatments for pcos good?

Focus On Cause: The signs and symptoms that arise for pcos are due to excessive estrogen. Any way that you can decrease estrogen exposure may help. Others may also recommend balancing your excessive estrogen with additional progesterone. You can explore decreasing your estrogen by reading: the anti-estrogen diet. ...Read more

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How effective are Cetuximab injections for treating colon cancer?

How effective are Cetuximab injections for treating colon cancer?

Some response: Erbitux was one of the first monoclonals develoed. It targets epidermal growth Factor 1 and is used in metastatic colon Ca that has the wild mutated KRAS. The best response is like Herceptin (trastuzumab) where this epidermal growth factor 2 mAb requires added chemo. As such when Colon Ca is treated with Erbitux + chemo there is an improvement in response for a number of months. No cures have been seen. ...Read more

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How effective are Leucovorin injections for treating colon cancer?

How effective are Leucovorin injections for treating colon cancer?

Not anti tumor: Leukovorum is used as an adjuvant or modifier of single or combinations of chemotherapeutic agents. It helps to prevent the toxic side effects of a number of chemotherapeutic agents including methotrexate. It also can be used to treat anemia caused by a lack of folic acid. It is added to combination of drugs employed in the supportive care of patients with colon cancer but does not have anticancer effects on diseases such as colon cancer, . ...Read more

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What non surgical treatments for endometriosis are effective?

What non surgical treatments for endometriosis are effective?

Many: There are many treatments and some women respond better to different treatments. Birth control pills can be taking in different ways to help with pain. Lupron injections are a very powerful and effective treatment.. Sometimes Progesterone or Norethindrone acetate helps. Acupuncturist can provide relief to some women. A Mirena (levonorgestrel) iud may help as well. Many options exist! ...Read more

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Dr. Michael Traub
1,248 doctors shared insights

Endometriosis (Definition)

A painful condition where the lining tissue of the uterus grows outside the uterus. This tissue causes pain when it bleeds ...Read more


Dr. Hamid Sajjadi
25 doctors shared insights

Gnrh (Definition)

Gnrh= gonadotropin releasing hormone is a hormone made in the hypothalamus of the brain involved with release of ...Read more