Doctor insights on:
Glyburide Vs Glipizide
Glipizide: Glipizide is an oral medication used to treat type 2 diabetes. The drug works by stimulating the pancreas to release additional Insulin so a partially functioning pancreas is necessary for Glipizide to work. Sometime Glipizide causes too much Insulin to be released by the pancreas which can lead to potentially dangerous low blood sugar (hypoglycemia). ...Read more
Diabetes pill.: Diabeta is a brand of the medication glyburide. It is an effective treatment for type 2 diabetes. It is available as generic Glyburide (lower in cost). It may not be the safest of this class, known as sulfonylurea medications, however (concerns about hypoglycemia in patients with kidney disease and heart effects in patients with heart disease). ...Read more
In general glyburide and other sulfonamides are well documented to increase risk of MI about 20% - there are safer options.
Invokana is a SGLTP2i- sodium glucose transport protein inhibitor, that results in sugar in the urine. It has actually been shown to protect kidney function over the long term. It also has a diuretic effect so should skip if you are dehdrated from scan or other reason ...Read more
An insulin releaser:
Glyburide (called glibenclamide outside the U.S.) Is a sulfonylurea anti-diabetic agent. It causes the pancreas to release insulin. It can do this even in the absence of food, so can cause the sugar to get too low.
Glyburide can be a problem in the elderly, again because of the risk for low blood sugar.
If you take this medicine, it could be dangerous to skip meals. ...Read more
Many options: When choosing a diet, make sure it's one that you can maintain lifelong so do not do anything drastic. In general, you should eat lots of vegetable and fruits. Non-starchy vegetables are best: spinach, carrots, broccoli or green beans. Eat whole grain foods instead of processed food (whole wheat over white breads) add fish to your meals 2-3 times per week. Dry beans & lentils are good protein... ...Read more
Glipizide 5mg xs 2/day. Lately #s rising slowly. Haven't changed anything)I don't think). Is diabetes progressive? Lots of fatigue also. : (
Yes, progressive: Hi. Yes, type 2 diabetes is progressive, and sufonylureas like glipizide have very poor durability. I haven't prescribed a sulfonylurea in YEARS. We have much better drugs with much more durable benefit. I would say if possible, you should see an endocrinologist; ask about GLP-1 receptor agonists, SGLT-2 inhibitors, and of course, good ol' metformin. Other options too. Good luck! ...Read more
Glipizide: Glipizide is the generic name for the anti diabetic drug glucotrol (glipizide). It is in the drug category of sulfonylureas. These drugs are very effective in treating type 2 diabetes. However, they can cause hypoglycemia (low blood sugar) if blood glucose is not monitored closely. ...Read more
Hypoglycemia: Prolonged hypoglycemia (mild to severe -low blood sugar- noted as tremor, sweating, headache, fatigue, confusion) is the most common/ concerning side effect of glyburide, this is due to its long half- life / active metabolite compared to other 2nd generation sulfonylureas. Minor weight gain seen. Nausea, heartburn (GI) are transient/ dose related. Rash/itching may occur. Liver injury is rare. ...Read more
Neither is my choice: Hi. I'm not a fan of sulfonylurea drugs (the class they're both in) and haven't written for any in years. Nevertheless, between the two, I'd prefer glimepiride by a slight margin. ...Read more
Varies (1 - 2 hours): Depending on the formulation ingested (micronized (glynase) or conventional Glyburide (diabeta, micronase)) onset of action ranges from about 1 to 2 hours with a maximum reduction of blood sugar seen within 3-4 hours. May last in body for over 18 to 24 hours. Should be taken with breakfast or main meal of the day to help reduce symptoms of low blood sugar (tremors, sweating, irritable, fatigue). ...Read more
Metformin: Possible side-effects include rash, palpitations, muscle aches, cramps, & changes in taste, . ...Read more
Yep: You bet you can.Get a more detailed answer ›
Allergic to metformin, glipizide 5 mg twice a day seems to not be as effective anymore. Suggestions?
Can metformin & glipizide mixed together? If yes than what is the possible side effect related to this
Taking glipizide XL and metformin bid. Did A1c and nurse said to take glipizide only in a.M. Now. What would that indicate?
Glipizide: I read this story as the nurse teaching you how you should have been using glipizde all along. This is a once daily medication. I see nothing else here that you should worry or wonder about. ...Read more
I need a prescription for Janumet 50/1000 60 tablets (take 2a day and I have a free 60 tablet voucher) and 60 tablets of glipizide 10 mg extended relea?
JANUVIA (sitagliptin): Onglyza, byetta, victoza, (liraglutide) etc. Plenty of choices. ...Read more
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other.
More important - you need to take control of your eating habits, your weight (if overweight), and your exercise.
Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose ...Read more
Either wth or after: Just so you don't skip meals to avoid hypoglycemia. ...Read more
Metformin: metformin most common side effect is stomach upset and loose stools. for this reason many healthcare professionals start at a low dose and gradually increase it to minimize adverse effects. glipizide can also cause nausea, headache, diarrhea; major effect is that it lowers blood sugar (which is why you are taking it) ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more