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Doctor insights on: Glyburide

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Dr. Luis Curet
131 doctors shared insights

Glyburide (Overview)

Used with diet and exercise to help control blood sugar in patients with type 2 diabetes. It is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfa drugs.


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What are potential problems with glyburide?

What are potential problems with glyburide?

Hypoglycemia: Prolonged hypoglycemia (mild to severe -low blood sugar- noted as tremor, sweating, headache, fatigue, confusion ) is the most common/ concerning side effect of glyburide, this is due to its long half- life / active metabolite compared to other 2nd generation sulfonylureas. Minor weight gain seen. Nausea, heartburn (GI) are transient/ dose related. Rash/itching may occur. Liver injury is rare. ...Read more

Dr. Luis Curet
131 doctors shared insights

Glyburide (Overview)

Used with diet and exercise to help control blood sugar in patients with type 2 diabetes. It is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfa drugs.


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Please describe the medication: glyburide?

Please describe the medication: glyburide?

A sulfonylurea: A drug to treat diabetes by stimulating beta cell to produce/secrete more insulin but works no matter what blood sugar is- thus high rate hypoglycemia-low blood sugar; and weight gain significantly increased risk of adverse cardiovascular events amer assoc of clinical endocrinology recommends it be "used rarely, if at all" incretins much safer;no hypoglycemic risk if used without Insulin or su. ...Read more

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Is the glipizide more effective than glyburide and januvia (sitagliptin)?

Is the glipizide more effective than glyburide and januvia (sitagliptin)?

No: Depending on how high your initial sugar levels are all 3 will lower the a1c about 0.3-1.0%. Glyburide is a poor choice for people with kidney problems and januvia (sitagliptin) is expensive. Most guidelines suggest beginning with metformin. Talk to your doctor. ...Read more

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Is glyburide safe for women who are pregnant or breastfeeding?

Is glyburide safe for women who are pregnant or breastfeeding?

Yes: Glyburide is sometimes used by some physicians during pregnancy for diabetes but this is not the most standard treatment. Most diabetics requiring medication will be changed to Insulin to control blood sugar during pregnancy. ...Read more

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How long does it take for glyburide to become effective?

Varies (1 - 2 hours): Depending on the formulation ingested (micronized (glynase) or conventional Glyburide (diabeta, micronase)) onset of action ranges from about 1 to 2 hours with a maximum reduction of blood sugar seen within 3-4 hours. May last in body for over 18 to 24 hours. Should be taken with breakfast or main meal of the day to help reduce symptoms of low blood sugar (tremors, sweating, irritable, fatigue). ...Read more

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Are there long term effects of diabetes medication (glyburide, metformin)?

Are there long term effects of diabetes medication (glyburide, metformin)?

Not many: Glyburide is a sulfonourea (it forces your pancreas to produce more insulin). Metformin does three things... It helps your Insulin work better by making the Insulin receptors in the body more sensitive, it slows glucose absorption in the intestine, and slows the production of glucose by the liver. ...Read more

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Overdosed w/glyburide(190pills) dec2011, now i'm experiencing a lot of nausea (not pregnant).Could it be a long term affect from the overdose?

Overdosed w/glyburide(190pills) dec2011, now i'm experiencing a lot of nausea (not pregnant).Could it be a long term affect from the overdose?

Doubtful: The meds are out of your system. It is unlikely you would have a long-term reaction. Follow up with your doc. ...Read more

Dr. Zahid Niazi
24 doctors shared insights

Glynase Prestab (Definition)

Glynase PresTab is a second generation sulfonylurea which is a kind of diabetes-related drug ...Read more


Dr. James Chapman
25 doctors shared insights

Micronase (Definition)

Micronase is a second generation sulfonylurea which is a kind of diabetes-related drug ...Read more