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Doctor insights on: Glutamate Receptors

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Is there a test to detect autoantibodies against metabotropic glutamate receptors?

Is there a test to detect autoantibodies against metabotropic glutamate receptors?

You asked for it: Yes, there is. It's for research. Abs to the mGluR1 subunit of metabotropic Glu receptor 1 have been found in small groups of ataxia pts. They're also detected in nonimmunological neurological diseases eg stroke & trauma but these may be epiphenomena (due to spillage of cell contents outside the blood-brain barrier). If you're concerned, my advice is: Find something else to worry about. ...Read more

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more

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Are there any natural supplements that effect the glutamate receptor in a positive way?

Are there any natural supplements that effect the glutamate receptor in a positive way?

Magnesium: I would say, that magnesium have the potential forhaving a positive effect on the glutamate receptors. I say this, because magnesium for the most part, inhibits excitation which would salvage these receptors. ...Read more

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Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Possibly, not likely: There may be a possible tests to detect antibodies to the peripheral tissues, but it would likely require a biopsy. It would be very difficult to differentiate antibodies also because they would be in present in your entire body rather than just in one location. ...Read more

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What things, in the body, regulate glutamic acid? Glutamic acid decarboxylase? Glutamate receptors (nmda, ampa...Etc.)? What else is involved?

It's complicated...: There are some very exciting discoveries on the metabolism of glutamate... There are multiple pathways impacting on things such as gaba neurotransmitter, nitrogen clearance from the liver portal, etc... These pathways play vital roles in survival! please read this.... And email me your questions if you'd like! http://voh.Chem.Ucla.Edu/vohtar/spring04/classes/153ch/pdf/kelly%20and%20stanley.Pdf. ...Read more

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L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?

L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse.  Could I have glutamate metabolism disorder or glutamate receptor antibodies?

Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more

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What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

What would cause an intolerance to glutamic acid? Gad autoantibodies?  Gad deficiency?  Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?

None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read more

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Msg makes me have panic attacks and burning pain all over with extreme irritability. Is this caused by glutamate receptor problem or channelopathies?

Msg makes me have panic attacks and burning pain all over with extreme irritability.  Is this caused by glutamate receptor problem or channelopathies?

MSG symptom complex : The proposed mechanism is though to involve exaggerated sensitivity to msg which is metabolized to glutamate, a dominant excitatory Amino Acid neurotransmitter. Msg is a normal constituent of food protein and rarely causes symptoms when excess amount are not added to food. The complex has to do with upregulation of normal receptors as opposed to a channelopathy or a glutamate receptor problem. ...Read more

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What happens to pyruvate and glutamate when fasting?

What happens to pyruvate and glutamate when fasting?

You've pushed me---: I've been avoiding this question (as my colleagues have as well). I never was a fan of biochem in college or medical school. But I still have&refer to my Lubert Stryer from time to time...not the most recent edition you understand but mine is SPECIAL. Anyways, I'm still going through the chapter on amino metabolism which partially explains this so stay tuned. I promise to answer this shortly! ...Read more