Doctor insights on:
What kind(s) of specialist(s) would be able to diagnose & treat glutamate metabolism disorders and nitrogen metabolism disorders?
1-Step Metabolomics: Any physician can order the most broad-spectrum screen for metabolic disorders: "one-step metabolomics". Here is a link to a video demonstration of the technique. http://www.jove.com/video/2014/one-step-metabolomics-carbohydrates-organic-amino-acids-quantified. ...Read moreSee 1 more doctor answer
Glutamate metabolism dysregulation is associated with cancer. What comes first, glutamate metabolism dysregulation or cancer?
Not simple: Cancer is ultimately a genetic disease, that is cancer cells have mutations not found in normal cells. Some mutations are in genes affecting metabolic pathways, including glutamate metabolism, and the abnormal metabolism may contribute to the progression to invasive cancer. So your question is sort of a chicken and egg one; ultimately it is the mutation that is what starts a cancer. ...Read more
Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more
What kinds of doctors treat metabolic disorders (glutamate metabolism, nitrogen metabolism, methylation disorders)?
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
If you have a glutamate metabolism disorder...& then you eat a food high in glutamic acid (meat, gluten, casein..Etc), what happens to you? Symptoms?
A lot: Glutamate overall is an excitatory protein in the body. It stimulates the perception of taste and appetite. It also acts on the pancreas and liver. Our bodies need some but too much can cause a lot of different problems such as weight gain, diabetes, and neurotoxicity. In addition to avoiding high glutamate foods it is useful to consume extra carnitine (high in red meat) to counter the glutamate. ...Read more
What could cause disorders of glutamate metabolism besides genetic causes? Viruses? Heavy metals? Pancreas/liver problems?
Primarily genetic: Almost totally genetic. Why do you believe you have a disorder in glutamate metabolism? ...Read more
Can a person be genetically predisposed to develop a disorder of glutamate metabolism later in life? How could you test for this?
Could a glutamate metabolism disorder either directly or indirectly cause my stool to constantly have strong ammonia smell for last few years?
More likely GI flora: You are in distress and high gad65 ab can cause brain effects. Environmental influences possible. Avoid tobacco, alcohol, processed foods, dairy, grains except quinoa, and sugar.Eat plenty of fresh vegetables and some wild caught fish. Check 25-oh vit d. Eat 6 equal meals a day followed by relaxation breathing for 5 minutes , and mild exercise for 10-15 minutes. Read kelly mcgonigal. ...Read moreSee 1 more doctor answer
Can high gad-65 autoantibodies cause glutamate metabolism disorder (gmd)? What tests confirm gmd? My plasma ammonia is normal & anti-gad ab's high
Can cause diabetes.: It seems these autoabs can cause stiff man's syndrome, a neurological disorder with impaired motor function and muscle stiffness and spasm. There is also a great deal of glutamic acid decarboxylase in the pancreas and so these antibodies act here and produce diabetes mellitus in the patient. This is likely the metabolic disorder involved. So titers of this ab, glucose, and neural tests help. ...Read more
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