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Doctor insights on: Gluconeogenesis

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Whats pyruvate dehydrogenase complex?

Whats pyruvate dehydrogenase complex?

Enzymes: Pyruvate dehydrogenase complex is a complex of three enzymes in the mitichondria that change the Amino Acid pyruvate into the molecule acetyl-coa by a process called pyruvate decarboxylation. Acetyl-coa is used in the citric acid cycle to make energy for cells the complex links the metabolic pathway that breaks down glucose (elemental sugar) to the citric acid cycle. ...Read more

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Is pyruvate dehydrogenase deficiency heritable?

Is pyruvate dehydrogenase deficiency heritable?

Yes.: In the most common situation it is inherited in an x-linked pattern, affecting hemizygous males (with one x chromosome) and heterozygous females (two x chromosomes, one with mutation). Less commonly it is inherited in an autosomal recessive pattern, in which a mutation must be provided by both the mother and the father of the affected person. ...Read more

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Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?

Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more

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Does metformin regulate glucose made by liver? What's best way to treat diabetics, control liver glucose production or pancreatic insulin production?

Does metformin regulate glucose made by liver? What's best way to treat diabetics, control liver glucose production or pancreatic insulin production?

Yes but there's more: One of metformin's actions is reducing liver glucose production. It also helps improve the body's use of insulin, aka Insulin sensitivity. This is key to long term health with diabetes. Eating smart, exercise, and keeping to a good weight also help. Metformin is our usual first choice & meds that increase pancreatic Insulin production are not , but you & your doc must pick what's best for you. ...Read more

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Which relation between bilirubin metabolism and glucose?

Which relation between bilirubin metabolism and glucose?

None: Hi. There is no direct relationship between bilirubin metabolism & glucose metabolism. ...Read more

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How much does novorapid (insulin aspart) insulin reduce blood sugar?

How much does novorapid (insulin aspart) insulin reduce blood sugar?

Depends: Depends on your degree of control/resistance and how much of the Insulin you inject. In general, it's a quick acting Insulin and can lower your blood sugar very fast. ...Read more

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What causes pyruvate dehydrogenase complex deficiency?

What causes pyruvate dehydrogenase complex deficiency?

Mitochondrial diseas: A very rare genetic disorder which leads to neurodegeneration. Presenting in infancy or later childhood, the earlier presentation is usually more severe. Those who develop symtpoms later in childhood may survive into adulthood. ...Read more

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Does your body process different sugars differently (eg. Glucose, fructose, sucrose, lactose, etc.)?

Does your body process different sugars differently (eg. Glucose, fructose, sucrose, lactose, etc.)?

With minor: Differences, your body can easily metabolize any sugar. Glucose, fructose and galactose are all simple sugars or monosaccharides. Sucrose, maltose and lactose are all compound sugars or disaccharides. Sucrose is formed as a combination of a molecule of glucose and one of fructose, and they are broken apart by enzymes. All are equal to 4 calories / gram. ...Read more

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Does sweetener zero calories contain lactose sucrose leucine crosscarmellose sodium which is diet sweetener effect on triglycerides like sugar ?

Does sweetener zero calories contain lactose sucrose leucine crosscarmellose sodium which is diet sweetener effect on triglycerides like sugar ?

Sweeteners: Don't have calories, i agree. The trouble is that our taste mechanism is made up of 6 stimulants--- sweet, sour bitter, salt, astringent, and metal. All god made food provides flavor from permutations and combinations of the 6. A single sweet input provides a jolt of pleasure that is addictive. It is brain signals that govern our ability to adapt to our environment. We need to obey diet rules. ...Read more

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What nutrients stimulate angiogenesis?

What nutrients stimulate angiogenesis?

InternalBodyControls: If food made us what we are, they we would likely look like what we eat; reality far more complex. The bodies we inhabit: chemical wizards taking apart molecules & reassembling them like fantastic complex tinker toys under internal controls, called biochemistry. Current knowledge: ischemia, ?pressure diff. & flow may trigger complex responses ?angiogenesis & ?inhibitory controls: balance critical. ...Read more

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My bl sugar level drops to 50 3 h after eating,normal insulin, c-peptide, liver enzymes' levels,family history of diabetes,is it reactive hypoglycemia?

My bl sugar level drops to 50 3 h after eating,normal insulin, c-peptide, liver enzymes' levels,family history of diabetes,is it reactive hypoglycemia?

Reactive hypoglycemi: yes. It is. Whenever you eat ready sugars or simple sugars( made with table sugar, juices) your body releases lots of insulin . Your sugars get absorbed mostly from stmach and there is still insulin in the blood that continue to lower your sugar.you should avoid ready sugars and take more complex carbs. Along with proteins. You most likely will be developing diabetes in near future. So watch !! ...Read more

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Which is rate metabolic disorder 4 hydroxy butyric aciduria?

Which is rate metabolic disorder 4 hydroxy butyric aciduria?

Probable ketosis: Beta hydroxybutyric acid is a compound formed during starvation, or diabetic ketoacidosis as the result of fat breakdown for energy in the absence of carbohydrates the question here is unclear, perhaps re submit? ...Read more

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Where is fructose metabolised?

Fructose is Sugar: In the gut as it is absorbed. It is sugar and that is all it is or will become unless there is too much and then the liver will metabolize it and turn it into fat storage molecules known as triglycerides. ...Read more

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Has 'branched chain amino acids' (bcaa) diet suplement some negative affects on human body? (kidneys, liver etc.?)

Has 'branched chain amino acids' (bcaa) diet suplement some negative affects on human body? (kidneys, liver etc.?)

?beneficial: Likly to be beneficial in variety of conditions as source of protein. I am not sure the price you pay. Is worth it as egg white is as good a protein which comes. In natural form. ...Read more

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How can eating carbohydrate build muscle or insulin increases protein synthesis?

Everything: You eat is broken down into small building blocks and metabolized into calories of energy. Your body then uses this energy to generate proteins, fats, carbohydrates or whatever else it needs to manufacture. Insulin is an anabolic hormone which does stimulate protein synthesis, but increasing your Insulin levels does not lead to muscle building. ...Read more

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