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Doctor insights on: Glucocorticoid Stomach Damage

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Does corticosteroids cause stomach ulcers?

Does corticosteroids cause stomach ulcers?

They may: Especially high dose oral corticosteroids like Prednisone taken for longer periods of time. Inhaled corticosteroids used for the treatment of asthma and allergic rhinitis rarely, if ever, cause or exacerbate existing stomach ulcers. ...Read more

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I think glucocorticoids have caused my muscle cells to die. How can I prove this?

Nothing to prove: It's certainly possible to lose muscle particularly after long term high dose steroids. If you're now off of them, exercise can return some muscle mass, but it's very slow. ...Read more

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Will glucocorticoids restore ovulation in NCAH? And how long approx until it does so?

Will glucocorticoids restore ovulation in NCAH? And how long approx until it does so?

Often, yes: Hi. Treating nonclassical congenital adrenal hyperplasia (CAH) with dexamethasone (dex) is the standard therapy and often restores normal cycling and fertility. The dex dose should be adequate to suppress adrenal androgen production but be low enough to not cause Cushing's. It may take months for ovulatory periods to resume. Good luck! ...Read more

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Do glucocorticoids suppress all parts of the immune system, or suppress some parts and increase the activity of other parts?

Do glucocorticoids suppress all parts of the immune system, or suppress some parts and increase the activity of other parts?

Complicated: The answer is complicated. In general glucocorticoids suppress the immune system by interfering with protein production in cells. That being said, glucocorticoids also work on receptors in the cytoplasm of cells, enacting signal mechanisms, some of which are unclear as to action. Glucocorticoids also release food stores for use in a stress reaction. ...Read more

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What's glucocorticoid hormone?

What's glucocorticoid hormone?

Hormon: Adrenall gland secrete glucoticoid that is the same as steroid/cortison. ...Read more

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Can cause glucocorticoids erythematous lesions?

Can cause glucocorticoids erythematous lesions?

Thin skin: Chronic glucocorticoids lead to thinning of the skin and fragile capilaries which leads to easy bruising. ...Read more

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How do glucocorticoids help in a stress response?

How do glucocorticoids help in a stress response?

Not the best drug: Considering your pituitary problems you would be much better off with another drug and or a psychologist and also consult with your endocrinologist.. ...Read more

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How do glucocorticoids activate the intrinsic pathway?

There are many: "intrinsic" pathways. Which one do you mean? ...Read more

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Does glycyrrhizic acid (in liquorice root) have glucocorticoid effects? If so, has it ever been studied for use in treating lo-cah? Study links?

Does glycyrrhizic acid (in liquorice root) have glucocorticoid effects?  If so, has it ever been studied for use in treating lo-cah? Study links?

No: Glycyrrhizinic acid inhibits an enzyme in the kidney (11?-hydroxysteroid dehydrogenase). This enzyme inactivates cortisol in the kidney. Inhibition of this enzyme leads to decreased inactivation of cortisol and thus to increased cortisol levels. Not expected to work in cah since this is characterized by an inabilty to make cortisol. ...Read more