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Doctor insights on: Glucocorticoid Combination With Methotrexate

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My mother have rheumatoid arthritis and her doctor prescribed methotrexate & adalimumab (sub-q), did this combination too heavy for health or normal?

My mother have rheumatoid arthritis and her doctor prescribed methotrexate  & adalimumab (sub-q), did this combination too heavy for health or normal?

No: This is appropriate combination therapy for uncontrolled ra. The benefits of these meds in preventing joint damage and disability far outweighs the risks. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What do you think of the combination of celebrex (celecoxib) and sulfasalazine to treat RA beside taking other medications such as methotrexate and Enbrel ? Instead of Norco or motrin or tramadol

What do you think of the combination of celebrex (celecoxib) and sulfasalazine to treat RA beside taking other medications such as methotrexate and Enbrel ? Instead of Norco or motrin or tramadol

Depends on severity: It depends on the severity and activity of your RA. Enbrel and Methotrexate are great drugs if you have active. If it is not active Celebrex (celecoxib) and sulfasalazine are alternatives. We discourage people to use narcotic painkillers for non cancer pain for the long term since it is very addictive and people become tolerant for the doses and expect increasing doses ...Read more

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Rheu Dr stoped Predn after 9months.only on methotrexate n plaqunil now. I have severe flare up now I want to take 20 mg predn without Dr know can I?

Rheu Dr stoped Predn after 9months.only on methotrexate n plaqunil now. I have severe flare up now I want to take 20 mg predn without Dr know can I?

Absolutely not: This has the potential for serious consequences to your health and will likely destroy your relationship with your doctor. Discuss the addition of a biologic agent with your doctor. ...Read more

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How well does methotrexate work?

How well does methotrexate work?

Need more info: Methrotrexate is used for many diseases. Please ask this question again and be specific about what the Methotrexate is being used for. ...Read more

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Do you have information on methotrexate uses and effects?

Many and quite safe!: Mtx is used in many autoimmune diseases with great effect. The drug is given IV in high doses to treat cancer. In much lower doses, given subcutaneously like insulin, with fewer side-effects than the same oral dose, does not go to the liver. And you absorb 100%, not the 40-90% when taken by mouth. Great drug. Ist line in ra! ...Read more

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What would weekly methotrexate injections do to a person?

What would weekly methotrexate injections do to a person?

A mainstay for...: The treatment of rheumatoid arthritis and psoriatic arthritis, and other inflammatory conditions! i administer to my patients mtx by the subcutaneous route, thereby insuring 100% absorption and bypassing stomach and liver. When given with folic acid, i rarely see significant problems for my patients! ...Read more

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Any methotrexate side effects?

Any methotrexate side effects?

Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more

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Is it harmful to take methotrexate?

Yes, if no indicatio: It will be harmful if no indication to take. However, if there is a strong indication- it is something that is tolerable. Just like any other medication, there will be some possible adverse events- and this is something that you have to discuss with your doctor- to weigh the benefit and the risk and make a decision. ...Read more

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Would an overdose of methotrexate kill you?

Would an overdose of methotrexate kill you?

No if well hydrated: When heavy doses of MTX were first given to children this was followed by calcium leucovorum. First child not rescued by mistake and when returned no problem noted. child well hydrated. In adults it is essential when giving doses >1000 mg. to make sure hydration complete followed by rescue. ...Read more

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Should i take methotrexate if I have a cold?

Should i take methotrexate if I have a cold?

see details: When in doubt it is always prudent to skip a week. This question is best directed to the doctor who is prescribing it. ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more