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Doctor insights on: Globulin Low

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Low auto lymph high globulin low a/G RATIO?

Low auto lymph high globulin low a/G RATIO?

A/G ratio: If you are referring to a low albumin to globulin ratio, this lab parameter only has significance when taken into context with the information gathered by the doctor from history, physical, and other labs. A low A/G ratio ( ...Read more

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What does it mean to have low alk phos levels and ALT levels globulin low and could there be something underlying?

What does it mean to have low alk phos levels and ALT levels globulin low and could there be something underlying?

Not concerning.: There is generally no significance to low levels of ast or alkaline phosphatase. In a healthy pt it is very unlikely that low globulin is of any concern. ...Read more

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Blood work shows gam globulin low at 0.7 and M-spike, SPE, g/fl abnormal at 0.3. Two para protein bands in gam. Region. How serious is this?

Blood work shows gam globulin low at 0.7 and M-spike, SPE, g/fl abnormal at 0.3. Two para protein bands in gam. Region. How serious is this?

Need more info: I am assuming that you had a serum electrophoresis performed for one reason or another. The "normal" and "abnormal" in this case can only be judged in context rather than in absolutes, so more information is necessary. Did you have a urine electrophoresis? Any other results? Free light chains? Did your doctor state that you have protein in the urine? ...Read more

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Had high alk phos and absolute eosphils. 10. .. also elavated bun/crea and globulin. Low vit d and calcium. Is it my kidneys? Could it be lymphoma?

Had high alk phos and absolute eosphils. 10. .. also elavated bun/crea and globulin. Low vit d and calcium. Is it my kidneys? Could it be lymphoma?

Need for evaluation: You have mentioned enough abnormal results to warrant a thorough evaluation of your health. Elevated BUN/Creat are the most serious. Please see your doctor and follow her/his advice for further evaluation and treatment. This issue is not suitable for this forum or self treatment. ...Read more

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What causes high globulin, but low globulin albumin ratio?

What causes high globulin, but low globulin albumin ratio?

Liver blood tests: The liver is an amazing organ- it does many things including making proteins your body needs. Albumin is a major protein product of the liver. Chronic illness can cause that to decline- esp. If you're not eating. Globulins are other proteins usually made to fight diseases like infections- perhaps you've been fighting an illness for a few weeks/months that explain this pattern. ...Read more

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Had an annual cbc, all normal except albumin a little high and globulin little low, co2 is a little high (again). Is that bad?

Had an annual cbc, all normal except albumin a little high and globulin little low, co2 is a little high (again). Is that bad?

Normal: In medicine we done "chase the numbers" except in a few cases like TSH levels. It is better to look at the symptoms. If you are doing fine without symptoms, then I wouldn't worry. ...Read more

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Doc wants to do protein electrophoresis test. Globulin always low and a/g always high. Could globulin just be low due to my igg3 deficiency, though?

Doc wants to do protein electrophoresis test. Globulin always low and a/g always high. Could globulin just be low due to my igg3 deficiency, though?

Globulin: Globulin production affects immunoglobulin
production, hence your low igg3 is a result of your low globulin level and this needs to be investigated. Your doctor is right. ...Read more

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I have high albumin, high a/g, low globulin. Why does doc want 2 do protein electrophoresis? I thought globulin was low due 2 my igg3 deficiency.

I have high albumin, high a/g, low globulin. Why does doc want 2 do protein electrophoresis? I thought globulin was low due 2 my igg3 deficiency.

Ask your doctor: Yes, you may be correct. Your doctor may be looking for something else with a more detailed test. Communicate. If you cannot and it is because of your doctor, find a new one. Good luck and hope this works out. ...Read more

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Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

CSF: Some experts consider CSF protein levels to be normal if the value is equal to or below your age in years. I don't think in your case there is a reason to worry. Other CSF components are important as well. Check with your physician to see if there is any reasons to worry. Hope you feel well soon. ...Read more

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What does having low globulin levels mean and how can I get it to normal?

What does having low globulin levels mean and how can I get it to normal?

Be more specific: There are lots of globulins & to answer your question we need to know the type and reason the test was done. People have a range of antibody levels, globulins in certain classes, IgA, IgG, Ig E, or specific globulins to a prior illnesses or vaccinations. Without knowing specifics we cannot provide a specific answer. You are welcome to start over. Posts are not linked so each must have all info. ...Read more

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In my case I have low globulin 1.8 and high a/g ratio. I definately fasted prior. I'm a 31 year old female. Healthy. I do try to eat a lot of protein?

In my case I have low globulin 1.8 and high a/g ratio. I definately fasted prior. I'm a 31 year old female. Healthy. I do try to eat a lot of protein?

Insufficient info: Globulins consist of a number of different proteins, and you need a serum protein electrophoresis, as a start, for a detailed examination of the different proteins. Please consult the doctor who ordered the test. ...Read more

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Low globulin, high albumin/globulin, high ALT what does it mean?

Need more info: Lab test results need to be interpreted in the clinical context and is best done by the doctor who ordered the test as s/he likely knows your health history. A doctor needs to know the actual values of the results and more clinical information. ...Read more

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Hello. My blood work shows slightly Low Globulin and High Alanine 2.1 low and 49 high What could this mean?

Hello. My blood work shows slightly Low Globulin and High Alanine 2.1 low and 49 high What could this mean?

Incomplete info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the information your provided does not add up. It would be prudent to discuss it with the doctor who ordered the tests.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more

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What can cause low serum globulin, 1.5 (reference cutoff 1.6)? Can slightly low globulin have an affect on the accuracy of other labs?

What can cause low serum globulin, 1.5 (reference cutoff 1.6)? Can slightly low globulin have an affect on the accuracy of other labs?

May not be anything.: It's not clear if such a small reduction means anything. Globulin on a chemistry panel measures a group of blood proteins that include antibodies. A low globulin can mean lowered immunity, but not always. Additional testing (quantitative immunoglobulins) should be done to verify normal immune function. ...Read more

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Is low globulin count due to long term use of doxycycline hyclate 150mg?

Is low globulin count due to long term use of doxycycline hyclate 150mg?

Doubtful: But possible. Check with your doctor regularly and have blood work to make sure improving. There may be other causes and most of the time this isn't a worrisome issue unless severe or getting worse and worse. ...Read more

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Docs overlooking lymphoma? Months w/ab pain, rectal blood (cscope ok), lymph pain, non-healing acne, episodic fuo. Neg mono test. Latest labs = high ldh, high lipase, low globulin, pos for atyp wbcs

Docs overlooking lymphoma? Months w/ab pain, rectal blood (cscope ok), lymph pain, non-healing acne, episodic fuo. Neg mono test. Latest labs = high ldh, high lipase, low globulin, pos for atyp wbcs

.: I'm not exactly sure what you mean by lymph pain. But if you are having episodes of fevers and chills, unexplained abdominal pain for months, high ldh, this could warrant a ct scan with contrast (if kidneys okay) to look for a cause. Could be lymphoma but most probably not as lymphoma is not that common. Talk to your doctor. ...Read more

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What could a high immunoglobulin g 1660 and low a1 globulin 1.9 & a2 globulin 10.6 mean?

What could a high immunoglobulin g 1660 and low a1 globulin 1.9 & a2 globulin 10.6 mean?

IgA Deficiency: Sounds like selective IgA deficiency, if these are the results. Selective IgA deficiency is the most common immunodeficiency in the world and is usually benign but needs to be followed. IgA def in women is more significant since it can convert to common variable immune deficiency and there is HUGE risk of lymphoma development in the 50's-60's. See an immunologist ...Read more

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Tested for autoimmune and reoccurring chest/sinus/flu illness cause. Low gamma globulin and IgG but normal subclasses, is this significant to symptoms?

Tested for autoimmune and reoccurring chest/sinus/flu illness cause. Low gamma globulin and IgG but normal subclasses, is this significant to symptoms?

See allergist/immuno: Thought I have answered a very similar question. You need to get tested on how your body responds to vaccination (usually pneumococcal and tetanus toxoid) since it is not just the quantity but the function of your IgG which matters the most. A B/C allergist should be able to handle this for you ...Read more

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2yo has for last 2 yrs high temps, seizures at end of temps, low protein globulin, no immunity to tetanus mumps diphtheria?

2yo has for last 2 yrs high temps, seizures at end of temps, low protein globulin, no immunity to tetanus mumps diphtheria?

See details: There is, as you know, a potentially very serious issue. It may suggest significant compromise of the immune system related to such issues as hypogammaglobulinemia. Seek specialized pediatric evaluation such as with a pediatric immunologist. If there is a medical school reasonably close, consider seeking help there. ...Read more

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Very large lymph node on post. Neck with reticulo count at 10400 but hemoglobin at 8.6? albumin 3.3 and gamma globulin 2.3. Wbc low at 2.9? Help.

She needs help.: She should be under the care of a hematologist now. She needs an extensive physical exam wit more stidies. ...Read more

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Does low serum globulin affect blood tests that assess immunoglobulin levels? For example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?

Depends: If your immunoglobulin (s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly. ...Read more

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I have high ESR high serum globulin protine levels and low albumin levels plus ive had right sided pelvic/hip pain for the past 10 months?

I have high ESR high serum globulin protine levels and low albumin levels plus ive had right sided pelvic/hip pain for the past 10 months?

See your doctor: Without actual numbers, I can't be of much help. You should definitely be fully worked up, with protein and urine electrophoresis, and X-rays of your pelvis and hip. ...Read more

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Why would an immunologist put me on bactrim (sulfamethoxazole and trimethoprim) for a whole year? Should I take probiotic with them? I am 53 years old and have low beta globulin.

Why would an immunologist put me on bactrim (sulfamethoxazole and trimethoprim) for a whole year? Should I take probiotic with them? I am 53 years old and have low beta globulin.

Bactrim (sulfamethoxazole and trimethoprim): Bactrim (sulfamethoxazole and trimethoprim) has been used for prevention of urinary tract infections. This approach is being used less these days for several reasons. Treatment for a whole year seems surprising even if your immunoglobulins (gamma globulin) are low. If you have had lots of certain infections maybe he want to prevent more. But the likelihood of getting resistance is high with chronic use of most antibiotics. Bactrim (sulfamethoxazole and trimethoprim) has been used and proven beneficial for prevention of pneumocystis pneumonia. Many immunologists might use antibiotic at the first sign of infection. Ask him/her what the evidence is for this therapy, its pros and cons. Nothing wrong with taking a probiotic with this. ...Read more

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Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

>100, 000 proteins: Globulin = total proteins less albumen, the most abundant protein. While globulins includes antibodies, it also includes many other proteins. Within the 5 antibody subclasses (IgM, IgG, IgA, IgE & IgD), with >100, 000 specific binding activities for just IgG, the whole point is the ratio of relative targeting specifics, competing physiologic controls & responses. Globulin can be ↓ & targeting also ↑ ...Read more

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Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?

Complicated: When I was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more

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Smoke/alco free 15 months. New labs show high ldh + lipase; borderline low amylase + globulin. Already ruled out ibd, celiac, mono, hep, hiv, tb, lupus, ra. July ct=normal liver/kidneys/panc. Cancer?

Smoke/alco free 15 months. New labs show high ldh + lipase; borderline low amylase + globulin. Already ruled out ibd, celiac, mono, hep, hiv, tb, lupus, ra. July ct=normal liver/kidneys/panc. Cancer?

MRCP: Looks like you have pancreatitis, but if you have not had alcohol, need mrcp to see if there any pancreatic duct abnormalities. Need more info, were you drinking before and did you have multiple pancreatits before? Mrcp followed by eus would help. Ercp may be needed once acute episode is resolved, or if you find any stricture in the duct. ...Read more

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If your albinum level is low does that mean your globulins level and protein will elevate.

Not necessarily: It would depend on why the albumin is low.
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex.
Get HPV vaccine ...Read more