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Doctor insights on: Global Scleroderma

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Global dysfuction: what does "global" mean?

Multiple systems: Global dysfunction refers to illness or pathological status of multiple portions of the body rather than one specific system. Global therefore indicates a broad pattern of involvement. ...Read more

Dr. Pierre Moeser
184 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases can affect the ...Read more


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Transient global amnesia treatment?

Transient global amnesia treatment?

Typical no need: Tga, by virtue of being transient, resolves spontaneously without treatment. It is usually thought to be a migraine aura-based mechanism. Do no harm and reassure the person of what they are asking about would be my advise. ...Read more

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MRI brain results Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

MRI brain results  Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

Covering the bases: That signal that is seen in patients who age is seen very frequently. Most of the time it is what has become known as microangiopathic disease or small vessel disease. Demyelination and gliosis come with a more notable history. Gliosis or scarring and demyelination also produces symptoms that MRI is useful for. Depends on why you had the MRI in the first place. The first entity more common than 2 ...Read more

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Is scleroderma genetic?

Is scleroderma genetic?

Yes: In certain groups such as the choctaw population in oklahoma there is a strong genetic component. There is also a difference in populations between the different continents. ...Read more

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Are migraines associated with global cerebral ischemia?

Are migraines associated with global cerebral ischemia?

So complicated: In short, no - migraines are not a hypoperfusive state. The old (not correct) understanding in fact was based on the observation that blood flow often increases with migraines. Like all things in the body, our understanding now is much more complicated. There's a complex interaction between the neurons (primary problem) and the vessels and surrounding structures (secondary). ...Read more

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Help me, 59yrf-dercum's disease, lymphedema, ans disorder, heart disease- mi x3, 10+herniated discs, autoimmunity, gastroparesis, duodenitis w nodule?

Help me, 59yrf-dercum's disease, lymphedema, ans disorder, heart disease- mi x3, 10+herniated discs, autoimmunity, gastroparesis, duodenitis w nodule?

Too many issues here: If you do have all these listed problems, you need a good internist to take care of you and guide you further. Health matters get complicated if you truly have more than one or 2 ailments and you need long term care for any such diseases that are chronic in nature. You need a good primary care doctor to guide you for the long term. ...Read more

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Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

It can be: Sensorimotor peripheral neuropathies have many types and various causes. Some of them can be disabling, even long term in some cases. A thorough search will have to include blood tests and urine tests. In some cases spinal tab (lumbar puncture) can be necessary. In delineating the diagnosis. ...Read more

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Cerebral palsy & mental illness common?

Cerebral palsy & mental illness common?

Behavior cer palsy: Behavioral problems are common in children with cerebral palsy. Child psychiatric disorders were found in 57% of the children, including 28 children meeting criteria for an attention deficit disorder, which was the most common (bjorgaas et al 2012) communication problem was significantly associated with having a psychiatric disorder. Early evaluation for children with CP may prevent severe behavio. ...Read more

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Is the cognitive dysfunction that results from systemic lupus erythematosus typically permanent?

Is the cognitive dysfunction that results from systemic lupus erythematosus typically permanent?

It depends: Lupus can cause both reversible and irreversible changes to the nervous system, and these can affect personality, memory, and other basic aspects of patients' lives. That said, simply being sick can aggravate depression, sleep deprivation, etc. Controlling pain and other disruptive elements of the disease, can improve quality of life and help people be more who they would like to be. ...Read more

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61healthy.MRIbrain..Multiplefoci of flairhyperintensityinbilateral subcortical whitematterare nonspecifi findingsoften seenwith chron vas isc chang

61healthy.MRIbrain..Multiplefoci of flairhyperintensityinbilateral subcortical whitematterare nonspecifi findingsoften seenwith chron vas isc chang

Common findings: These are findings that are often found in every person's MRI of the brain that hold very little significance. You can say they are the "liver spots" of the brain. ...Read more

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Is autism associated with celiac disease?

Is autism associated with celiac disease?

No: Autism is a complex neurobiological inherited disorder that is worsened by environmental toxins. Celiac disease is a digestive disorder that prevents absorption of gluten from the diet. There is no scientific evidence the two are related. Years ago, there was a flurry of thinking that malabsorption of gluten could lead to or worsen autism. This has been disproven. ...Read more

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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What is global severe hypokinesis?

What is global severe hypokinesis?

Hypokinesis: Global severe hypokinesis means the whole heart is contracting poorly. It implies very significant heart muscle dysfunction. ...Read more

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What is severe global hypokinesia?

What is severe global hypokinesia?

Heart don't squeeze.: I suspect you are talking about a cardiac echo. Global hypokinesis means that the heart as a whole is contracting less well than would be expected. This could be the result of a cardiomyopathy, severe multivessel disease or any one of a number of metabolic or infectious causes. Best to see the one who ordered the test. ...Read more

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CT-Thorax extensive mediastinal lymphadenopathy with central caseation ,tuberculous lymphadenopathy to consider skin test,blood cultural neg itisTB?

CT-Thorax  extensive mediastinal lymphadenopathy with central caseation ,tuberculous lymphadenopathy to consider skin test,blood cultural neg itisTB?

Common things common: In India, there is a high prevalence of TB. With those imaging findings, I would be very suspicious of that. Good you're en route to getting a diagnosis and treatment. Of course it could be other diseases, but TB would be at the top of my list. You are young and should be able to pull through this. Keep fighting! ...Read more

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Is progressive supranuclear palsy a demyelinating disease?

Is progressive supranuclear palsy a demyelinating disease?

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more

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Dr. Al Hegab
143 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more