Doctor insights on:
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other.
More important - you need to take control of your eating habits, your weight (if overweight), and your exercise.
Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more
No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read more
I use 4 mg amaryl (glimepiride) morn and night, added 100 mg invokana, sugar 150-165 at night, can I increase either drug, 61 yr male, 189 lbs, a runner.
Yes: Invokana can be increased up to 300mg/day in patients that tolerate the drug. It appears that you are already at the max daily dose of amaryl, (glimepiride) and likely wouldn't add an additional benefit to increase the dose. You should talk with your doctor before increasing any drug. ...Read more
Are glimepiride&metformin safe drugs for a diabetic of12yrs. Cretanine now 1.2.Are these drugs safe or they shud be changed. Any advice to change meds.
Yes.: Metformin is considered first line therapy for type II diabetics. It should be stopped if your creatinine goes over 1.3-1.4 or for certain procedures using contrast dye for a couple days. The advantage for both is that they are cheap. Are there better choices than glimipiride? Yes. It pushes the pancreas to secrete more insulin and can "wear out" cells. Newer options exist but expensive. ...Read more
Both type 2 drugs: Hi. Metformin and glimepiride are both type 2 drugs. Metformin is an insulin sensitizer - makes tissues (predominantly liver but also muscle) more sensitive to insulin. Glimepiride is an insulin secretogogue - makes your own pancreas secrete more insulin. They are synergistic used in combination. To your good diabetes control! ...Read more
Type 2 drugs: Hi. Metformin is an insulin sensitizer and predominantly works at the liver to increase sensitivity to your own insulin (or exogenous insulin) to reduce the release of sugar from your liver into the blood. Glimepiride stimulates the release of insulin from your pancreas (insulin secretogogue). The 2 drugs are synergistic together. They may or may not control your diabetes. Good control is the goal ...Read more
Glimepiride and metformin hydrochloride which group of drug are they in and what are their purposes?
Diabetes is a condition where Insulin does not work well and there is insufficient insulin. Metformin works to overcome some of the Insulin resistance and reduce excessive glucose production from the liver.
Glimepiride works on the cells that make Insulin to augment Insulin deficiency and both together lower blood sugar. ...Read more
Hyperglycemic patient, a sudden hyperglycemia to more than 430 ml/dl, what type of emergency drug can be used in home? Pt use glimepiride & metformin
Insulin: The only way to address rapid rise in blood glucose is with a sliding scale of regular Insulin (or its equivalent injectable). The pills take too long and are too broad-acting to use for this purpose. If happens more than once every several months, talk to dr about having an Insulin option to help 'reset' blood glucose when climbing too high. ...Read more
Amaryl (glimepiride) effect/time: Amaryl (glimepiride) works by stimulating beta cells in pancreas to produce insulin.It should start working right away as it gets absorped, if after two weeks you don't see its effect on blood sugar, than you will need to increase the dose gradually to the maximum dose, to see the ful effect. Often you have to use another drug with it like metformin or actose. ...Read more
Can I take my. 5 mg of glimepiride in the late afternoon. I have trouble with low bs if I take it during the day.?
Possibly OK.: There is no reason it can't be done, but there may be a reason it shouldn't be done. Discuss with your doctor. ...Read more
Amaryl (glimepiride): Amaryl (glimepiride) has half life of 5 to 9 hours, after 5 half lives 95% of the drug is out of your system. So mutiply 5-9 by 5, so that makes it 25 to 45 hours. ...Read more
Depends: Generally if you miss a dose, you take it as soon as you remember unless it’s almost time to take your next dose, then you would skip the missed dose. ...Read more
Unknown: If you have type ii diabetes and you have uncontroled blood sugar, when you start glimepiride, your blood sugar gets under control and that can change the refractive index of your cornea and lens and that changes you vision. Make sure your blood sugar is in normal limit and then have your doctor check for need for glasses. ...Read more
Consult your plan: If you have normal renal function the preferred brand for your healthplan is the one to take - if you feel there is a need to change from a sulfonylurea to a dpp4i. Dpp4is have the same efficacy in lowering bs as glimeperide. Dpp4is have been implicated in increased pancreatitis and pancreatic and thyroid cancers. A better choice if you have good renal function is metformin. ...Read more
Why?: There might be more details in the question that I'm missing but don't stop any meds without talking to your prescribing physician first. ...Read more
Sulfonylurea.: That seems like a lot of sulfonylurea type medication - Glimepiride and Glyburide. The reason why that's important is that they can cause hypoglycemia (low blood sugar) which can be dangerous. I'd like to see you on more Metformin and less sulfonylurea to reduce your risk of hypoglycemia. ...Read more
I am having DM taking glimepiride 1mg once daily. How to confirm whether I am type1 DM or type2 DM?
Neither is my choice: Hi. I'm not a fan of sulfonylurea drugs (the class they're both in) and haven't written for any in years. Nevertheless, between the two, I'd prefer glimepiride by a slight margin. ...Read more
I am type2 DM taking amaryl (glimepiride) 1mg once daily. I am 30 year old female. I am not getting good control with tablet can I use insulin? Which is safe?
DM: Type 2 DM is typically associated with Insulin Resistance. Most type 2 diabetics can do very well if they can stick to a good low carb diet and regular exercise which promotes weight loss and helps with Insulin resistance. Metformin may also be helpful for Insulin resistance in type 2 DM. If all of this has been tried, your doctor can make the decision regarding if Insulin needs to be started. ...Read more