Doctor insights on:
Glimepiride And Pioglitazone Medication
Yes, unless: Hi. Yes, in general that 3-drug cocktail is safe. Exceptions would be metformin at a certain level of kidney disease, pioglitazone in heart failure, and glimepiride if it's causing hypoglycemia. That 3-drug regimen will likely lose efficacy over time. Keep your diabetes, blood pressure, and lipids tightly controlled. Don't smoke! Good luck! ...Read more
I take glimperide 4mg x2, metformin 1000mg x2, and pioglitazone 45mg.How should I be taking these meds any specific combinations ?
Just a thought:
but , in my opinion, the number and amount of oral medication you are taking indicate that you and your treating physician should consider INSULIN.....My opinion only
BTW the amount/timing/combination of these three drugs is dependent upon your blood sugar and when these sugars are measured
Hope this is helpful
Dr Z ...Read more
Pt 60 years , well controlled dm and htn, now suddenly developing ankle edema progressing chf? , discontinue pioglitazone+metformin+glimepride?
Diabetic medication: Actos (pioglitazone) is a prescription medication used with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. Actos (pioglitazone) is not for patients with type 1 "juvenile" diabetes or diabetic ketoacidosis. Actos (pioglitazone) works on two of the common problems that lead to high blood sugar in type 2 diabetes. ...Read more
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
Diabetes: Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other. More important - you need to take control of your eating habits, your weight (if overweight), and your exercise. Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more
I use 4 mg amaryl (glimepiride) morn and night, added 100 mg invokana, sugar 150-165 at night, can I increase either drug, 61 yr male, 189 lbs, a runner.
Yes: Invokana can be increased up to 300mg/day in patients that tolerate the drug. It appears that you are already at the max daily dose of amaryl, (glimepiride) and likely wouldn't add an additional benefit to increase the dose. You should talk with your doctor before increasing any drug. ...Read moreSee 1 more doctor answer
No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read moreSee 1 more doctor answer
Are glimepiride&metformin safe drugs for a diabetic of12yrs.Cretanine now 1.2.Are these drugs safe or they shud be changed.Any advice to change meds.
Yes.: Metformin is considered first line therapy for type II diabetics. It should be stopped if your creatinine goes over 1.3-1.4 or for certain procedures using contrast dye for a couple days. The advantage for both is that they are cheap. Are there better choices than glimipiride? Yes. It pushes the pancreas to secrete more insulin and can "wear out" cells. Newer options exist but expensive. ...Read more