Doctor insights on:
Glimepiride And Pioglitazone Medication
Yes, unless: Hi. Yes, in general that 3-drug cocktail is safe. Exceptions would be metformin at a certain level of kidney disease, pioglitazone in heart failure, and glimepiride if it's causing hypoglycemia. That 3-drug regimen will likely lose efficacy over time. Keep your diabetes, blood pressure, and lipids tightly controlled. Don't smoke! Good luck! ...Read more
Pt 60 years, well controlled dm and htn, now suddenly developing ankle edema progressing chf? , discontinue pioglitazone+metformin+glimepride?
Swelling: Do not stop any medication on your own. Need to discuss with doctor that is treating your CHF and dm. ...Read more
Actos (pioglitazone) is a prescription medication used with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. Actos (pioglitazone) is not for patients with type 1 "juvenile" diabetes or diabetic ketoacidosis.
Actos (pioglitazone) works on two of the common problems that lead to high blood sugar in type 2 diabetes. ...Read more
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other.
More important - you need to take control of your eating habits, your weight (if overweight), and your exercise.
Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more
I use 4 mg amaryl (glimepiride) morn and night, added 100 mg invokana, sugar 150-165 at night, can I increase either drug, 61 yr male, 189 lbs, a runner.
Yes: Invokana can be increased up to 300mg/day in patients that tolerate the drug. It appears that you are already at the max daily dose of amaryl, (glimepiride) and likely wouldn't add an additional benefit to increase the dose. You should talk with your doctor before increasing any drug. ...Read more
No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read more
Are glimepiride&metformin safe drugs for a diabetic of12yrs. Cretanine now 1.2.Are these drugs safe or they shud be changed. Any advice to change meds.
Yes.: Metformin is considered first line therapy for type II diabetics. It should be stopped if your creatinine goes over 1.3-1.4 or for certain procedures using contrast dye for a couple days. The advantage for both is that they are cheap. Are there better choices than glimipiride? Yes. It pushes the pancreas to secrete more insulin and can "wear out" cells. Newer options exist but expensive. ...Read more
Lowering blood sugar: This med helps to lower blood sugar by improving the cell ability to respond to Insulin as well as reducing sugar-producing ability of the liver. It has quite a few significant side effects and currently a big concern is risk of bladder cancer for long-term use (more than 1 yr). So, if you are on it, follow-up/consult doc regularly. Good luck. ...Read more
Both type 2 drugs: Hi. Metformin and glimepiride are both type 2 drugs. Metformin is an insulin sensitizer - makes tissues (predominantly liver but also muscle) more sensitive to insulin. Glimepiride is an insulin secretogogue - makes your own pancreas secrete more insulin. They are synergistic used in combination. To your good diabetes control! ...Read more
Type 2 drugs: Hi. Metformin is an insulin sensitizer and predominantly works at the liver to increase sensitivity to your own insulin (or exogenous insulin) to reduce the release of sugar from your liver into the blood. Glimepiride stimulates the release of insulin from your pancreas (insulin secretogogue). The 2 drugs are synergistic together. They may or may not control your diabetes. Good control is the goal ...Read more
Glimepiride and metformin hydrochloride which group of drug are they in and what are their purposes?
Diabetes is a condition where Insulin does not work well and there is insufficient insulin. Metformin works to overcome some of the Insulin resistance and reduce excessive glucose production from the liver.
Glimepiride works on the cells that make Insulin to augment Insulin deficiency and both together lower blood sugar. ...Read more
Hyperglycemic patient, a sudden hyperglycemia to more than 430 ml/dl, what type of emergency drug can be used in home? Pt use glimepiride & metformin
Insulin: The only way to address rapid rise in blood glucose is with a sliding scale of regular Insulin (or its equivalent injectable). The pills take too long and are too broad-acting to use for this purpose. If happens more than once every several months, talk to dr about having an Insulin option to help 'reset' blood glucose when climbing too high. ...Read more
Her are some side: Effect of actos:muscle pain -- up to 5.4 percent, tooth problems -- up to 5.3 percent', sore throat -- up to 5.1 percent, swelling or water weight gain, and others not as frequent but could serious.•symptoms of bladder cancer, symptoms of low blood sugar, trouble breathing, swelling, especially in the legs or ankles, rapid increase in weight, liver problems. Good luck. ...Read more
Depends: Generally if you miss a dose, you take it as soon as you remember unless it’s almost time to take your next dose, then you would skip the missed dose. ...Read more
Neither is my choice: Hi. I'm not a fan of sulfonylurea drugs (the class they're both in) and haven't written for any in years. Nevertheless, between the two, I'd prefer glimepiride by a slight margin. ...Read more
I'm not a fan: Hi. The TZD era came and went for me. They're not bad drugs in most cases, but they can cause serious weight gain and fluid retention, and we have such better drugs now. I haven't prescribed pioglitazone in years. So, yes, it helps treat diabetes, but other drug choices may have better overall profiles. ...Read more