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Doctor insights on: Gleevec

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Dr. Andrew Seibert
33 doctors shared insights

Gleevec (Overview)

Gleevec is an aklylating agent which is a kind of cancer drug.


Dr. Liawaty Ho Dr. Ho
2 doctors agreed:
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Is treatment necessary for systemic mastocytosis? I am taking gleevec (imatinib). What would happen if i stopped taking it?

Dr. Liawaty Ho Dr. Ho
2 doctors agreed:
Is treatment necessary for systemic mastocytosis? I am taking gleevec (imatinib). What would happen if i stopped taking it?

D/w oncologist: There are indolent systemic masto, and agressive systemic mastocytosis (asm). Many times, with indolent disease- therapy will be aimed only to control the symptoms- itching, diarrhea etc. If you have an asm- then usually treatment is started. Asm can manifest from slowly progressive to rapid fatal disease.Organ involvement , transformation to other blood DX including acute leukemia can happen. ...Read more

Dr. Andrew Seibert
33 doctors shared insights

Gleevec (Overview)

Gleevec is an aklylating agent which is a kind of cancer drug.


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What testing do I need to have in order to get gleevec (imatinib)?

What testing do I need to have in order to get gleevec (imatinib)?

C-kit analysis: Whether patients with gist are candidates for Gleevec (imatinib) depends on the status of a particular gene called c-kit, or cd117. This is a test that must be run on the tumor biopsy tissue and is generally coordinated with the help of the pathology laboratory. In select cases, some patients are candidates for Gleevec (imatinib) regardless of their c-kit results, but this is highly individualized. ...Read more

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Noticed there is a serious interaction between flomax, which i was just prescribed, and gleevec, but none with sprycel, (dasatinib) which i take for cml. Correct?

Noticed there is a serious interaction between flomax, which i was just prescribed, and gleevec, but none with sprycel, (dasatinib) which i take for cml. Correct?

Increase serum Floma: Gleevec increases serum levels of flomax, and therefore dosage adjustment may be necessary. Flomax is metabolized through cyp3a4 and sprycel (dasatinib) is also a substrate for cyp3a4, so may also increase the levels of flomax. ...Read more

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Emily Lu Dr. Lu
2 doctors agreed:
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If you don't have the gene to use gleevec, (imatinib) will the drug help at all?

Emily Lu Dr. Lu
2 doctors agreed:

No: Gleevec (imatinib) is a targeted cancer therapy, which means that it is only effective against cancer cells with a particular genetic mutation. It will not be effective against cancer cells without the mutation. ...Read more

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What should I do if I have to take gleevec (imatinib) for leukemia and its hard to work because it makes me so sick?

What should I do if I have to take gleevec (imatinib) for leukemia and its hard to work because it makes me so sick?

Call Oncologist: There are a large amount of information on different approaches to manage toxicity based upon the response of the cml. It is expected that people will live for decades with CML on treatment. There are dose changes and other agents to be considered. Don't stop the drug. Have a discussion with your oncologist about the options for you to be functional. ...Read more

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Meds effects (gleevec) or not? 4 wks diarrhea, leg cramps, vomited last nite, no temp. E.R. or wait til 11/17 oncologist?

Meds effects (gleevec) or not?  4 wks diarrhea, leg cramps, vomited last nite, no temp.  E.R. or wait til 11/17 oncologist?

See below: Serious side effects can be severe blistering skin rashes, jaundice, gastrointestinal bleeding, weakness with shortness of breath, severe headaches, swelling, and severe flu-like symptoms. Development of these symptoms requires urgent medical evaluation If none of above, just call oncologist and report symptoms per phone. But do this be4 the 11/17 visit Best wishes for continued health ...Read more

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What is the life expectancy of a man in good general health with cml x 6 years in remission with gleevec (imatinib) 400mgs po qd.?

Good: From the study, about 70-75% people are still being on Gleevec (imatinib) and still on complete remission for over 12 years now. In addition to gleevec, (imatinib) we have 3 other medications available- i.e. Dasatinib ( sprycel), nilotinib ( tasigna) and the newest one- bosutinib ( bosulif) that you can use if needed. So, i will say that for a leukemia, the life expectancy in CML is actually pretty good. ...Read more

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One of the side effects of gleevec (imatinib) is bone pain. I can't take nsaids.I am on a combination of Duragesic and vicodan.Any suggestions other than narcs?

One of the side effects of gleevec (imatinib) is bone pain.  I can't take nsaids.I am on a combination of Duragesic and vicodan.Any suggestions other than narcs?

Adjuvant therapy: There is good evidence that shows anti-epileptic medications, Gabapentin and Lyrica (pregabalin) specifically, can work in conjunction with opioids in reducing pain as they work on different pain receptors. Cymbalta has also been approved for various pain conditions including back pain, osteoarthritis pain, fibromyalgia, diabetic peripheral neuropathy, etc. ...Read more

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Anyone know of effects with gleevec (imatinib)?

Gleevec (imatinib) info: Open this link: http://www.Nlm.Nih.Gov/medlineplus/druginfo/meds/a606018.Html.

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Dr. Chad Levitt
28 doctors shared insights

Imatinib Mesylate (Definition)

Imatinib mesylate is a carbapenem which is a kind of anti-bacterial ...Read more