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Doctor insights on: Girlfriend Clinically Depressed Zoloft Wants Smoke Pot

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My girlfriend is clinically depressed and currently on zoloft (sertraline). She wants to smoke pot..Side efcts?

My girlfriend is clinically depressed and currently on zoloft (sertraline). She wants to smoke pot..Side efcts?

Bad idea: Mixing antidepressant medication with smoking marijuana is a bad idea but unfortunately all to common. The effects are unpredictable and highly individually variable. It may increase depression, render the medication ineffective, cause paranoia, increased mood swings, irritability. Don't join her in smoking pot and encourage her to ask her doctor about it. ...Read more

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Dr. Pamela Pappas
4,484 doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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I am on wellbutrin (bupropion) 150mg for ADD and 25mg zoloft for anxiety. I smoke pot and my highs are better than ever since im on those meds. Why?

I am on wellbutrin (bupropion) 150mg for ADD and 25mg zoloft for anxiety. I smoke pot and my highs are better than ever since im on those meds. Why?

Multiple effects: You are benefitting from the effects of both medications on anxiety. Smoking pot is however countering the effects of Wellbutrin (bupropion) on your ADHD symptoms. Well researched studies have shown that smoking pot as little as once per week results in lowered IQ by about 5 points and brains have been shown to be smaller than average non smokers. ...Read more

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65 yrs old. On 150 mg Zoloft (sertraline) 5 yrs. After very scary severe second clinical depression diagnosed by a psychiatrist, is this dosage ok to continue.

 65 yrs old. On 150 mg Zoloft (sertraline) 5 yrs. After  very scary severe second clinical depression diagnosed by a psychiatrist, is this dosage  ok to continue.

Add expert therapy: That is a high but common dose. In the past use of SSRIs for years was not recommended, but now it is common. Never stop or change dose w/o guidance but do consider adding good talk therapy to optimize gains and resolve issues. All research supports this combo! Best wishes. ...Read more

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I have clinical depression with concentration/memory problems("I dont-remember why I came here" severe). Will zoloft/effexor improve conc/memory a lot?

I have clinical depression with concentration/memory problems("I dont-remember why I came here" severe). Will zoloft/effexor improve conc/memory a lot?

Possibly: Concentration & memory problems are fairly common with major depression. Treating the depression may help with those symptoms. However - I would not prescribe both those meds at the same time. ...Read more

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I've been taking 100mg Zoloft (sertraline) for depression for about a year. Can i smoke marijuana? I am experienced with pot smoking and i no longer feel depressed

I've been taking 100mg Zoloft (sertraline) for depression for about a year. Can i smoke marijuana? I am experienced with pot smoking and i no longer feel depressed

You can, but don't: Of course you are in charge of what you do or don't do. But i suggest refraining from marijuana if you have a history of depression and are on zoloft (sertraline). It doesn't matter that you're "experienced with pot smoking.". ...Read more

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I have depression and took Zoloft (sertraline) but stopped and all I do is sleep all the time i don't know what to do?

I have depression and took Zoloft (sertraline) but stopped and all I do is sleep all the time i don't know what to do?

Normal: Sleeping a lot/fatigue is actually one of the hallmark signs of depression. Sounds like you need to see your doctor again. Is there a particular reason you stopped the zoloft (sertraline)? Were you having side effects, did it not seem to work, etc.? If you thought it wasn't working, how long did you take it before stopping? ...Read more

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I have chronic migraines & depression & take Zoloft (sertraline) & it doesn't work at all. What do you recommend that can work for both.

I have chronic migraines & depression & take Zoloft (sertraline) & it doesn't work at all. What do you recommend that can work for both.

Topiramate: You should see a headache specialist. Stop taking analgesics for your headaches. Go to bed and wake up at the same time each day. No smoking. Limit caffeine use to 2 cups daily. Exercise daily. No meal skipping. Consider using topiramate. ...Read more

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I have been on 100mg Zoloft (sertraline) for a month for anxiety. I don't think i feel better and i might even be depressed? Do i need to increase the dose?

I have been on 100mg Zoloft (sertraline) for a month for anxiety.  I don't think i feel better and i might even be depressed?  Do i need to increase the dose?

Talk w/your doctor: Are you working with a psychiatrist who prescribed the zoloft (sertraline)? It and other antidepressants require at least 4-6 weeks' trial for effectiveness. You may need a higher dose, but you need to discuss this with your own doctor who knows you much better than we on healthtap do. Please also avoid the alcohol since it can dysregulate your sleep and mood. ...Read more

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I'm on 100mg zoloft (sertraline). I don't feel depressed anymore unless its a bad day, but I still worry constantly. What can I do?.

I'm on 100mg zoloft (sertraline). I don't feel depressed anymore unless its a bad day, but I still worry constantly. What can I do?.

See a psychiatrist: Though ssris like zoloft (sertraline) can help some with anxiety (in addition to depression), some anxiety doesn't respond. The options include (1) switching medication, (2) adding an anti-anxiety medication, (3) starting psychotherapy for anxiety/depression (e.g. Cbt), (4) or all of the above. I'd suggest getting a referral to psychiatry to discuss specifics of treatment options. ...Read more

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If Zoloft (sertraline) 50 mg for 2 months didn't work at all for severe sa and reactive depression, will 100mg be supposed to work ?

If Zoloft (sertraline) 50 mg for 2 months didn't work at all for severe sa and reactive depression, will 100mg be supposed to work ?

Zoloft (sertraline) tx: Sa? Is that sad (seasonal affective disorder)? It looks like you have both depression and post traumatic stress disorder (ptsd). Zoloft is a good choice for ptsd. If you have significant ptsd sympotms or typical depressive symptoms that may well respond to the higher dose of zoloft. However, atypical depressive and sad symptoms often respond to a medication like wellbutrin (bupropion). Discuss with your dr. ...Read more

Dr. Donald Jacobson
1,039 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Caroline Cribari
550 doctors shared insights

Melancholia (Definition)

This is an old term for depression or dysthymia (mildly low mood), from the belief that it was caused by excess ...Read more