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Doctor insights on: Getting Off Zoloft Side Effects

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Dr. Donald Jacobson
1,039 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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How common is it to get side effects from taking zoloft (sertraline)?

How common is it to get side effects from taking zoloft (sertraline)?

Common: Side effects are common early on & most often diminish over time (a week or 2). If they are serious, fail to diminish, or are intolerable, then contact your prescriber immediately for instructions & consideration of alternative medication. See comment below. ...Read more

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Can I take 25mg of Zoloft (sertraline) twice daily ? When I take 50mg at once I get horrible side effects

Yes: Dividing the dose to Zoloft (sertraline) 25 mg twice daily is fine. Try to take consistently at the same time each day. Be sure to discuss with prescribing doctor. ...Read more

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My pdoc increased my Zoloft (sertraline) from 50mg daily to 100. Will i get side effects and how long to feel the effects of it working?

My pdoc increased my Zoloft (sertraline) from 50mg daily to 100. Will i get side effects and how long to feel the effects of it working?

Zoloft (sertraline): Not everyone gets side effects with zoloft (sertraline), (sertraline) even when the dose it raised. You are still well within a normal dose range. Many people need 150mg zoloft (sertraline) daily. Generally zoloft (sertraline) requires at least 4-6 weeks for effectiveness, although you may experience this sooner. ...Read more

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I have been on Zoloft (sertraline) 12.5mg for 3 weeks with the most horrible side effects. I no longer want to take this medicine. How do I get off of it?

Talk w/doctor: First, i suggest talking with your doctor about your decision. The zoloft (sertraline) must have been prescribed because of some symptoms you were having, and these may still need treatment even if zoloft (sertraline) is not the best option for you. You also haven't mentioned what "horrible side effects" you're experiencing -- but i'm sure your doctor would want to know so that something more helpful can be given. ...Read more

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About to increase my Zoloft (sertraline) dose from 50mg to 75mg. Will the sexual side effects get worse or stay the same usually?

Not much difference: Sexual side effects on SSRIs are generally dose related, but going from 50-75mg of Zoloft (sertraline) is not big enough to make much difference. If depression/anxiety improve sexual function might improve esp interest. Young men often find it helps sexual function as it prevents premature ejaculation . When I have a young man be very sensitive to sexual side effects of SSRIs, I suspect bipolar disorder. ...Read more

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My pdoc said that i can up the Zoloft (sertraline) dose from 150 to 200mg if i feel 150 doesn't help enough. Would upping it be wise? (i had 0 side effects so far)

My pdoc said that i can up the Zoloft (sertraline) dose from 150 to 200mg if i feel 150 doesn't help enough. Would upping it be wise? (i had 0 side effects so far)

Zoloft (sertraline): Zoloft (sertraline) can be raised to 200mg safely, in general -- but i'm wondering what the diagnosis is? You list "abnormally high sex drive"? Sometimes this can indicate a mood disorder with hypomania or mania -- and taking zoloft (sertraline) without a mood stabilizer can worsen that. I suggest consulting with a psychiatrist about your diagnosis and your medication. There may be more effective options for you. ...Read more

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Dr. Alan Ali
991 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more