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Doctor insights on: Genetics Sickle Cell Anemia

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Can you please tell me genetics of sickle cell anemia?

Can you please tell me genetics of sickle cell anemia?

Inherited disease.: Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Sickle cell anemia:is this birth defect only due to genetics?

Sickle cell anemia:is this birth defect only due to genetics?

Yes: It is a defect present from birth, yes. Would i call it a birth defect, no. It is a genetically derived abnormality in the metabolism of hemoglobin that results in sickling of the red cells under some circumstances. As a metabolic disease, it is inherited in a similar fashion to pku or cystic fibrosis. The term birth defect is more appropriate for a kid with malformation of an organ or body part. ...Read more

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Can the basic genetic defect of sickle cell anemia be treated?

Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells. ...Read more

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Is sickle cell anemia purely a genetic disorder?

Is sickle cell anemia purely a genetic disorder?

I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more

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What type of genetic disorder is sickle cell anemia or trait?

What type of genetic disorder is sickle cell anemia or trait?

Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more

Dr. Liawaty Ho Dr. Ho
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Is sickle cell anemia painful?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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Can I have sickle cell anemia?

Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

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Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Why is sickle cell anemia painful?

Why is sickle cell anemia painful?

Poor circulation: In sickle cell disease red cell stick together and block circulation to extremity and other organ so it cause pain crisis. ...Read more

Dr. Jay Park Dr. Park
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How is sickle cell anemia detected?

Dr. Jay Park Dr. Park
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Blood test: Every newborn baby undergoes "newborn screening" test before they are released from hospital. Most of abnormal hemoglobins, e.g. Hemoglobin s in sickle cell disease, are detected. ...Read more

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How dangerous is sickle cell anemia?

More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more

Dr. Liawaty Ho Dr. Ho
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What are the tests for sickle cell anemia?

Dr. Liawaty Ho Dr. Ho
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What are the tests for sickle cell anemia?

Hb electrophoresis: CBC and hemoglobin electrophoresis have to be done -at least- to make a diagnosis of sickle cell anemia. ...Read more

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What is the symptoms of sickle cell anemia?

Anemia, pain, crises: The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others. Most patients that have sickle cell trait are completely asymptomatic. ...Read more

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What kind of disorder is sickle cell anemia?

What kind of disorder is sickle cell anemia?

Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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What is the 'reverse' of sickle cell anemia?

What is the 'reverse' of sickle cell anemia?

None: Sicle cell anemia is an inherent disorder of the red blood cell. The reverse woould be normal blood cells. ...Read more

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What are the symptoms of sickle cell anemia?

Several symptoms: Sickle cell anemia leads to pain in the bones. It can also lead to shortness of breath, fatigue, chest pain, strokes. ...Read more

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What makes sickle cell anemia so significant?

Chronic disease: Sickle cell disease is so significant in that it is a chronic disease that affects almost every organ. Like diabetes, the effects of sickle cell, crises, and transfusions can permanently affect the heart, the kidneys, the liver, the lungs, and the brain. ...Read more

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Dr. James Ball
356 doctors shared insights

Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


Dr. Steven Ginsberg
1,285 doctors shared insights

Anemia (Definition)

A condition marked by a deficiency of red blood cells or hemoglobin in the blood, resulting ...Read more