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Doctor insights on: Genetic Testing After Miscarriage

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Should everyone have genetic testing before pregnancy?

Should everyone have  genetic testing before pregnancy?

Consultation first: Every couple can learn something from meeting with a clinical geneticist. They evaluate both family trees & can identify genetic issues you may be at risk for. With this information they can focus on which if any conditions to look for. There are in excess of 200 gene related defects they can identify, but there is no test that will identify all & many are studied only in a couple labs in the US. ...Read more

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Dr. Scott McLean
1,252 doctors shared insights

Genetic Testing (Definition)

Prenatal testing for genetic problems may be done before or after conception. Testing for spina bifida or Down syndrome is done after a pregnancy is established. Besides the couples listed above, counseling and diagnosis are also recommended for mothers over the age of 35, and those who have received abnormal screening test results, such as alpha-fetoprotein (AFP). For more information about the alpha-fetoprotein test, and when and why you might have it, see alpha-fetoprotein. For those who may be at risk, genetic counseling and prenatal diagnosis are used to help ...Read more


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Tissue testing after d&c showed up turners syndrome. What's the risk for future pregnancies. This was second early mc. Mother's age 32yrs ?

Tissue testing after d&c showed up turners syndrome. What's the risk for future pregnancies. This was second early mc. Mother's age 32yrs ?

Does not add up!: Women with Turner syndrome are infertile and do not get periods. Either the woman does not have Turner or she did not get pregnant. Please consult a geneticist for proper evaluation. ...Read more

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Do ovum donors undergo genetic testing or pedigree evaluation?

Do ovum donors undergo genetic testing or pedigree evaluation?

Yes: Check with your rei specialist for details, but all ovum donors would be asked to report a detailed family history and would be tested for common recessive disorders, such as cystic fibroisis. Many programs would also request more extensive testing including a panel of 100 such recessive diseases, including such problems as spinal muscular atrophy, the askenazi jewish panel, fragile x, & more. ...Read more

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Does noninvasive prenatal testing(cfDNA )capture baby's genetic defects?Is amniocentesis better for more accurate results? Im 31&12 weeks pregnant.

Does noninvasive prenatal testing(cfDNA )capture baby's genetic defects?Is amniocentesis better for more accurate results? Im 31&12 weeks pregnant.

Some and yes: The cf-DNA can detect many genetic anomalies but it is not 100% and when positive is usually confirmed by an amniocentesis for a full karyotype. The amniocentesis is the gold standard for detecting genetic anomalies . Sampling of the placental tissue _ ie: chorionic villus sampling would be comparable to an amniocentesis and can be performed earlier in the pregnancy. ...Read more

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Can genetic testing for sickle cell disease be done before birth of baby?

Can genetic testing for sickle cell disease be done before birth of baby?

Genetic test Sickle: Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. ...Read more

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What prenatal tests recommended even after PGS tested embryo. History of 3 MCs With turner's & Trisomy 14, age 34.Need 2nd opinion from few docs pls. ?

What prenatal tests recommended even after PGS tested embryo. History of 3 MCs With turner's & Trisomy 14, age 34.Need 2nd opinion from few docs pls. ?

Same tests: The curent recommendation is that patients who underwent preimplantation testing still undergo the usuall genetic testing during pregnancy. Your doctor can discuss options such as Sequential screening and cell free DNA testing. They may want to test for antiphospholipid antibodies based on your 3 miscarriages. ...Read more

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Chances of miscarriage after a miscarriage with chromosome abnormality?

Chances of miscarriage after a miscarriage with chromosome abnormality?

See below: After 1 miscarriage, the chances don't change...Still around 5-10% depending on the study. ...Read more

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Can genetic testing prevent birth defects in pregnancy?

Can genetic testing prevent birth defects in pregnancy?

Nope.: Genetic prenatal testing can detect many chromosomal or microscopic dna defects - but it cannot prevent birth defects! 2-4% of all newborns will have a minor or major birth defect and the vast majority of those have unknown genetic underpinnings at this time, although many of us are working to change that. Take Folic Acid 1-5 mg daily to prevent 75-95% of major neural/cardiac fetal anomalies! ...Read more

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Is it possible to get gestational diabetes after testing negative early in pregnancy?

Is it possible to get gestational diabetes after testing negative early in pregnancy?

Yes: Gestational diabetes can occur anytime during pregnancy. If you have symptoms/signs of diabetes, you should get tested again (just blood tests) despite the fact that you'd tested negative earlier on in pregnancy. ...Read more

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Is a noninvasive prenatal paternity bloodtest, done with blood from alleged fathers, cfdna and 317.000 genetic markers a reliable test?

Is a noninvasive prenatal paternity bloodtest, done with blood from alleged fathers, cfdna and 317.000 genetic markers a reliable test?

Yes: Make sure the identity of the alleged fathers and pregnant mother are confirmed. Make sure no tampering with the blood. Science can reveal the dna. ...Read more

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How early in a pregnancy can I have genetic testing done for downs syndrome?

How early in a pregnancy can I have genetic testing done for downs syndrome?

After10 weeks: First trimester screening can be done at 11-13 weeks. Definitive diagnosis by chromosome analysis can be done through cvs sampling after 10 weeks. ...Read more

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3 MCs no live birth. 2 MCs turner's & trisomy14 in fetus. Parents karyotyping normal. What other genetic tests shld be done. Risk of abnormal child ?

3 MCs no live birth. 2 MCs turner's & trisomy14 in fetus. Parents karyotyping normal. What other genetic tests shld be done. Risk of abnormal child ?

No need extra tests: No need for further tests before pregnancy since the parents chromosomes are normal. For early piece of mind you can consider early non-invasive genetic screening in early pregnancy. ...Read more

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Would a standard genetic test detect 22q11.2 deletion syndrome? My son had genetic testing done at 2 yo.

Would a standard genetic test detect 22q11.2 deletion syndrome? My son had genetic testing done at 2 yo.

Standard genetic ?: There are thousands of genetic related tests I am aware of and each has its uses for specific cases. A simple chromosome study would not pick up this deletion.A high resolution study would likely find it in most specialty labs.Some also do a specific study using a genetic probe.This is a question best answered by the folks who did the study in question. ...Read more

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Is brca genetic testing a simple blood test?

Is brca genetic testing a simple blood test?

Yes: BRCA testing can be performed from either blood or saliva. A significant amount of DNA needs to be present for adequate testing so most companies require more than a finger stick blood draw. Usually a single blood tube containing 3 ccs of blood is adequate ...Read more

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Will a vanishing twin (lost at 7 weeks) affect first trimester downs syndrome testing with blood test and ultrasound?

Will a vanishing twin (lost at 7 weeks) affect first trimester downs syndrome testing with blood test and ultrasound?

Vanishing twin: No, it would not affect your test result. Ultrasound would show it for a while, but the developing twin will eventually grow big enough to hide it from view. ...Read more

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Is HIV antibodies test conclusive at 3 months after exposure?and is DNA PCR test conclusive after 45 days after exposure?

Is HIV antibodies test conclusive at 3 months after exposure?and is DNA PCR test conclusive after 45 days after exposure?

HIV Infection: Technically speaking PCR is conclusive at the time of infection. The moment HIV enters the human blood stream it explodes. Viral tires go into the multiple millions. So testing by PCR would easily catch this. The problem is..it is not intended to be used as a screening test due to the cost. So..the antibody test at 3 months is good..but 6 months out is needed to be conclusive in my opinion. ...Read more

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Genetic testing at 11 weeks pregnant- how will this be done? Blood work?

Genetic testing at 11 weeks pregnant- how will this be done? Blood work?

Genetic testing: They will ask you a lot of questions about your family and the fathers family, they will assess the risk, and they will do a test- can now be done often with mucus but may be blood test ...Read more

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Positive pregnancy test 10 weeks after full term delivery: new pregnancy or residual pregnancy hormone from previous pregnancy?

Positive pregnancy test 10 weeks after full term delivery: new pregnancy or residual pregnancy hormone from previous pregnancy?

Probably a new preg: But, rarely, there is a hormone-producing tumor left from the pregnancy. See your ob/gyn; you may need a 24 hour hormone assay to dfferentiate it from a a normal pregnancy. ...Read more

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IPS test screen negative (17 wks preg). Should I risk amnio due to age and previous trisomy 18?

IPS test screen negative (17 wks preg). Should I risk amnio due to age and previous trisomy 18?

IPS screen: Making a decision about whether to have further testing can be difficult. Speak to your doctor about further testing. For additional in formation you can ask for a referral for genetic counseling. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


Dr. Seth Derman
512 doctors shared insights

Miscarriage (Definition)

A condition in which a woman experiences a loss of a pregnancy, typically prior ...Read more