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Doctor insights on: Genetic Predisposition To Disease

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If someone follows a regimen to avoid the onset of a certain disease but still develops it, is that indicative of a genetic predisposition?

If someone follows a regimen to avoid the onset of a certain disease but still develops it, is that indicative of a genetic predisposition?

Yes: Almost every medical condition has a genetic basis. Family history of disease predicts genetic predisposition & increases one's risk however the road to development of a disease is much more complicated. We know that predisposition is influenced by multi-factorial elements eg. environment, diet, viral triggers, & more. Some diseases appear by spontaneous gene mutation showing no familial trail. ...Read more

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Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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How do I know if I have a genetic predisposition to bipolar disorder?

How do I know if I have a genetic predisposition to bipolar disorder?

Family History: If you have a so-called first-degree relative (sibling, mother, or father), with bd your genetic "loading" for bd is higher than if you don't. However, lots of people have bd with no known family history; and, even if both your mother and father have bd, the risk that you will too still is only about 20%--way higher than the general population but not a sure thing. ...Read more

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Is it possible to test to see if you have a genetic predisposition for bipolar disorder?

Is it possible to test to see if you have a genetic predisposition for bipolar disorder?

Nospecific test: There is not a specific test for this. However, a strong family history of mood disorders including bipolar disorder would increase odds. ...Read more

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Could i be born with a genetic predisposition to bipolar disorder?

Could i be born with a genetic predisposition to bipolar disorder?

Yes: There's an incompletely understood genetic connection in bipolar disorder. The most convincing evidence is studies of monozygotic twins, in which there's increased likelihood of bipolar disorder in both twins if one presents with this disorder. Children of bipolar parents are at higher risk than others, of developing a mood disorder. Growing up with a bipolar parent brings risks also. ...Read more

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Is there a genetic predisposition for paranoia?

Is there a genetic predisposition for paranoia?

yes, but depends: Certain types of paranoia can have a genetic predisposition, and some times it can be caused by drugs or medications. Your best bet is to get a thorough evaluation by a psychiatrist and get a better answer that is specific to you. ...Read more

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Could there be a genetic predisposition to acne?

Could there be a genetic predisposition to acne?

Yes: There's a single good twin study. No locus was identified. Here you go: http://www.Ncbi.Nlm.Nih.Gov/pubmed/12485434. ...Read more

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Can lifestyle affect a genetic predisposition to cancer?

Yes and no: Genetic predisposition is what you are born with, for good or bad (like brca mutations causing breast and ovarian cancer). Can't do anything to change your genes although you can work to decrease the odds if you have a high risk gene. Lifestyle choices may increase the risk even more so avoiding unhealthy choices will be beneficial. In other words, change what you can but be aware of your risk. ...Read more

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Will making lifestyle changes matter if I have a genetic predisposition to being stressed?

Will making lifestyle changes matter if I have a genetic predisposition to being stressed?

Absolutely, yes!: Many of us live in an environment with is predisposed to stress, with or without genetic predisposition. Lifestyle changes can make a huge difference. Start with the basics ("easy", but challenging to incorporate in to your daily schedule): eat a healthy meal/snack every 3-4 hours, go to bed relatively early and get enough sleep, try to limit caffeine and alcohol, and get up and move every day! ...Read more

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Help plz! Can schizophrenia develop due to environmental factors alone without a genetic predisposition?

Psychosis: Psychosis can have different roots and some cases might look very similar to some Schizophrenia(s). But even they may have some predispositional contribution. As far as I've ever heard - Sz does have at least a significant genetic element. Best! ...Read more

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Can lifestyle affect genetic predisposition to get cancer? For example can healthy lifestyle decrease chance of cancer in jewish women

Yes: A healthy lifestyle (no tobacco, eating well, exercising) will reduce the risk of getting cancer in any person, jewish or not. Certain jewish and other ethnic groups have a higher risk than others (e.g. Ashkenazi jews and brca mutations) so gather as much family info as you can and discuss this with your doc. Live healthy please. Best regards. ...Read more

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Was I born with a genetic predisposition to infertility? 46xx

Was I born with a genetic predisposition to infertility? 46xx

46XX = normal female: 46, xx = normal female chromosome pattern. If you're 46, xx & male (very rare) you need to see a specialist. If you're a woman there is usually no identifiable genetic cause of your infertility. Fragile x syndrome is a rare cause of ovarian insufficiency/ early menopause. Some women whose mom had early menopause are increased risk of low ovarian reserve themselves. Chromosome translocations are rare. ...Read more

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Do any particular races have more of a genetic predisposition for developing alzheimer's?

Not really: Regardless of race, roughly 45% of pts by age 85 yrs will develop alzheimer's. A few families carry genetics which result in early presentation, but most cases, by far, are sporadic. This is an "equal opportunity" disease which occurs most often as a risk of the elderly, and any person of any race who ages is at risk. ...Read more

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Docs can you explain what is a genetic predisposition to serotonin imbalance?

Docs can you explain what is a genetic predisposition to serotonin imbalance?

Genetics: The theory is that depression runs in families. Depression is often treated by increasing serotonin levels. Thus, a serotonin imbalance may fe hereditary, . ...Read more

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Of women on birth control pills who have cardiac incidents, what percentage have secondary causes, such as smoking or a genetic predisposition?

Of women on birth control pills who have cardiac incidents, what percentage have secondary causes, such as smoking or a genetic predisposition?

Outstanding question: Excellent question! Let me re-phrase it: what is the risk of having any type of vascular event? It depends on exact formulation, duration of use, & risk factors. No prospective studies have been reported. Here is summary from the NIH: http://www.ncbi.nlm.nih.gov/books/NBK148774/. This reports odds ratios. If the risk is 1 in a million, an OR of 2 is only 2 per million. They're rare. ...Read more

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What are the pros and cons of commercial ( no prescription or doctor involved)snp DNA testing for genetic disorder/disease and/or predisposition to them?

Pros and cons: Pros: cheap, quick, high data quality cons: challenges in interpretation (particularly if no doctor is involved), limited tests available, privacy and potential medical/life insurance issues. ...Read more

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Are there genetic predispositions to a hiatal hernia?

Are there genetic predispositions to a hiatal hernia?

Rarely.: There have been reports of familial hiatal hernias (see reference). Most, however, are thought to be acquired. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc1727703/. ...Read more

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