Doctor insights on:
Genetic Predisposition To Disease
If someone follows a regimen to avoid the onset of a certain disease but still develops it, is that indicative of a genetic predisposition?
Yes: Almost every medical condition has a genetic basis. Family history of disease predicts genetic predisposition & increases one's risk however the road to development of a disease is much more complicated. We know that predisposition is influenced by multi-factorial elements eg. environment, diet, viral triggers, & more. Some diseases appear by spontaneous gene mutation showing no familial trail. ...Read moreSee 2 more doctor answers
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Family History: If you have a so-called first-degree relative (sibling, mother, or father), with bd your genetic "loading" for bd is higher than if you don't. However, lots of people have bd with no known family history; and, even if both your mother and father have bd, the risk that you will too still is only about 20%--way higher than the general population but not a sure thing. ...Read more
Yes: There's an incompletely understood genetic connection in bipolar disorder. The most convincing evidence is studies of monozygotic twins, in which there's increased likelihood of bipolar disorder in both twins if one presents with this disorder. Children of bipolar parents are at higher risk than others, of developing a mood disorder. Growing up with a bipolar parent brings risks also. ...Read more
Family History: Your family history should give you a good idea as to the genetic predisposition. ...Read more
Yes and no: Genetic predisposition is what you are born with, for good or bad (like brca mutations causing breast and ovarian cancer). Can't do anything to change your genes although you can work to decrease the odds if you have a high risk gene. Lifestyle choices may increase the risk even more so avoiding unhealthy choices will be beneficial. In other words, change what you can but be aware of your risk. ...Read more
Absolutely, yes!: Many of us live in an environment with is predisposed to stress, with or without genetic predisposition. Lifestyle changes can make a huge difference. Start with the basics ("easy", but challenging to incorporate in to your daily schedule): eat a healthy meal/snack every 3-4 hours, go to bed relatively early and get enough sleep, try to limit caffeine and alcohol, and get up and move every day! ...Read more
Can lifestyle affect genetic predisposition to get cancer? For example can healthy lifestyle decrease chance of cancer in jewish women
Yes: A healthy lifestyle (no tobacco, eating well, exercising) will reduce the risk of getting cancer in any person, jewish or not. Certain jewish and other ethnic groups have a higher risk than others (e.g. Ashkenazi jews and brca mutations) so gather as much family info as you can and discuss this with your doc. Live healthy please. Best regards. ...Read more
46XX = normal female: 46, xx = normal female chromosome pattern. If you're 46, xx & male (very rare) you need to see a specialist. If you're a woman there is usually no identifiable genetic cause of your infertility. Fragile x syndrome is a rare cause of ovarian insufficiency/ early menopause. Some women whose mom had early menopause are increased risk of low ovarian reserve themselves. Chromosome translocations are rare. ...Read moreSee 1 more doctor answer
Not really: Regardless of race, roughly 45% of pts by age 85 yrs will develop alzheimer's. A few families carry genetics which result in early presentation, but most cases, by far, are sporadic. This is an "equal opportunity" disease which occurs most often as a risk of the elderly, and any person of any race who ages is at risk. ...Read moreSee 1 more doctor answer
Of women on birth control pills who have cardiac incidents, what percentage have secondary causes, such as smoking or a genetic predisposition?
Outstanding question: Excellent question! Let me re-phrase it: what is the risk of having any type of vascular event? It depends on exact formulation, duration of use, & risk factors. No prospective studies have been reported. Here is summary from the NIH: http://www.ncbi.nlm.nih.gov/books/NBK148774/. This reports odds ratios. If the risk is 1 in a million, an OR of 2 is only 2 per million. They're rare. ...Read more
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