Doctor insights on:
Genetic Hemochromatosis And Statins
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Genetic causes- splenomegaly, fatty liver, seizures, fatigue, psychosis and ataxia?
Neg. For np a/b/c, lupus, wilson's and ashkenazi diseases
This is a lot: I wish my answer was as good as your question. Some of your symptoms could be part of an immunologically mediated illness. These as you know can have a genetic basis. You have looked in some important areas. Your evaluation may be a variety of laboratory studies genetics studies and tissue biopsies to help clarify. ...Read more
Most Do: Familial hypercholesterolemia is the most common genetic disorder involving choleterol levels . If a patient has an LDL cholesterol level above 200 he/she has familial hypercholesterolemia. It is transmitted in a way that each child has a 50/50 chance of inheriting this. On a microscopic level there is increased liver fat in all of these patients, it just may not show up on blood tests. ...Read moreSee 2 more doctor answers
Isn't the diagnosis for hemochromatosis based on irish hemochromatosis? Other races like far east have different gene for iron overload
Let me help: Most hemochromatosis worldwide is caused by mutations at the hfe gene locus; most europeans with a worrisome mutation here have c282y, but there are other alleles at this locus, and several other less common loci. Further, having the gene won't give you the disease unless you actually get iron-overloaded, which is how we pick it up. Any primary care doc can diagnose & rx is easy. Stay proactive. ...Read more
If liver enzyme levels are slightly elevated (alt 54) could this be due to fatty liver?Been vaccinated for hep a&b and don't meet hep c risk factors.
Female 61, ls heart failure, af thus metoprolol, history lifelong mitochondrial myopathy, pe, oa and nafld. Safe to take rosuvastatin for cholesterol?
Who knows?: You present a unique group of disorders in which statins have never been tested. Individually, none of your disorders, including your liver disease, are contraindications to rosuvastatin. I would start it and check ck, alt and ast (the known toxicities) at 6 weeks and 6 months. ...Read more
Slightly elevated BP low cholesterol and glucose. No family history. Smoke, regular alcohol, caffeine. No family history. Will good genes prevail ?
Why tempt fate?: Slightly elevated blood pressure does materially increase the work of heart. Losing weight may help. Neither tobacco nor alcohol are doing you any good. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
My father has high cholesterol and essential thrombocytosis (myloprolifitive disorder) his hs, CRP elevated at 4.5. Pravastatin & aspirin good treatm?
Does a normal serum copper level and serum ceruloplasmin level of 21 rule out wilson's disease? Have fatty liver with zero risk factors & mansymptoms
Total risk: It's not wise to treat lab abnormalities in a vacuum. If your total cardiac risk exceeds 7.5% ten year risk, or if you have established vascular disease, a statin is advised (2013 Adult Treatment Panel guidelines, American Heart Assoc) since they've been shown repeatedly to lower risk while supplements and non-statin meds are either ineffective or minimally so. ...Read more
Cholesterol of 5.4 LDL 3.6 and HDL 1.50 and osteoarthritis. Are statins essential? Unsure due to research on joints......
Would an LDL level of 172 at 28 suggest familial hypercholesterolemia? No family hx of heart disease. All grandparents lived well in to 70s & 80s.
Yes: Despite all the talk about "healthy living" and so forth, your LDL level is mostly genetic and if you need meds, you need meds -- remember that other lifestyle factors, especially smoking and fitness habits are under your control. In true familial hypercholesterolemia, the illness that kills folks around their 20's by itself, levels are much higher. Your physician's your best guide. ...Read moreSee 1 more doctor answer
A mild blood clotting disorder that is hereditary? Are there genetic tests both parents can take?
What disorder?: If one has a clotting disorder, and he/she would like to know if it is hereditary or not- he/she would need to complete some work-up. See a hematologist and discuss whether it is necessary that she/he ( not the parents) get the full comprehensive clotting work-up. ( the tests are for the patient and not for the parents. ). ...Read more
How and why is there an increase in urobilinogen levels in hepatocellular dysfunctions like alcoholic liver disease, cirrhosis and malignancy of liver?
Obstruction: When the liver is prevented from doing it's job due to disease it shows itself through elevation of certain chemicals in the blood because it is being blocked by physical disruption of the anatomy and bile goes into the blood causing yellowing of the skin ( jaundice). ...Read moreSee 1 more doctor answer
Can infants with homozygous familial hypercholesterolemia develop xanthomas or xanthelasmas? What are your expert opinions?
Gene dose effect: Hi. Is the infant homozygous or heterozygous for FH? Homozygotes can develop tendon xanthomata or xanthelasma in childhood. Many heterozygotes don't ever get xanthomata. If the infant is a homozygote, he/she has a tough road ahead; heterozygotes too, but very tough for homozygotes. Good luck! ...Read more
Several drugs exist which lower cholesterol by inhibiting an enzyme in liver cells (hmg-coa reductase) that is involved in cholesterol synthesis. These all have generic names that end in -statin, e.g. Atorvastatin (lipitor) and Simvastatin (zocor). Since nearly all of the meds in this class have been shown to have similar cardiovascular benefits, we often discuss them ...Read more