Top
20
Doctor insights on: Genes And Gene Therapy Cloning

Share
1

1
Is cell therapy different from gene therapy?

Is cell therapy different from gene therapy?

Yes: Cell therapy generally involves stem or pluripotent cells that have the potential, under the right triggers, to grow into many different types of cells. These cells are then transplanted to an area of disease. Gene therapy generally involves replacing small dysfunctional segments of dna. Dna is present in almost every cell in our body and is the instruction manual that tells the cell what to do. ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


2

2
Can gene thereapy alter a living persons genome?

Can gene thereapy alter a living persons genome?

No: Not at this point yet. The aim of such therapy would be not to alter the human genome but rather to correct it to make it as closer o normal as possible. ...Read more

3

3
Does alpha thalassemia trait have gene therapy available?

No: Alpha thalassemia trait only causes mild anemia, and the person usually has no symptoms. Gene therapy is not available and would not be needed. ...Read more

See 1 more doctor answer
4

4
Pros of viral vectors in gene therapy?

They work!: For gene therapy to work, material must be transported into cells, such as new genes to insert , or proteins that cleave (break apart) chains or delete genes. Since viruses are capable of entering cells (that is how they infect them) and are able to integrate their own genes into the dna inside the cell, they can be effective in gene therapy. But the virus must be or be made harmless first. ...Read more

5

5
How do dna, mutation, genotype, phenotype, and natural selection interconnect to cause evolution?

How do dna, mutation, genotype, phenotype, and natural selection interconnect to cause evolution?

Modern synthesis: It's as well-established as anything in science, but would take more than 400 characters to explain. You owe it to yourself, as an educated person who must participate in community decision making, to understand it. There are a huge number of good books on the subject. Best wishes. ...Read more

6

6
Are all brca gene mutations hereditary? Can you share some sources?

Are all brca gene mutations hereditary? Can you share some sources?

BRCA mutations: The majority of brca mutations are inherited from your mother or father. There are some which occur de novo(without inheritance). There is considerable information on the website for myriad- this is the company which has been doing the commercial testing in the usa. ...Read more

See 1 more doctor answer
7

7
What are germline gene alterations?

What are germline gene alterations?

Inheritable: "germline" refers to genes that are present in every cell of the body from conception or shortly afterwards, including sperm/ ova, and thus can be passed down to offspring. This term is used to distinguish these types of inherited genetic mutations from those that are not inherited - not present in the dna of sperm or ova. ...Read more

9

9
Cause of a positive monoclonal T cell beta gene rearrangement?

Cause of a positive monoclonal T cell beta gene rearrangement?

Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more

10

10
What are hox genes and their role in development?

What are hox genes and their role in development?

Hox genes: not enough room here to give good answer. I would go to wikipedia and then if you need more information go yto https://www.ncbi.nlm.nih.gov/pubmed/ and search hox genes AND reviews. ...Read more

11

11
How do a gene mutation and a chromosomal mutation differ?

How do a gene mutation and a chromosomal mutation differ?

Mutations: A chromosome will contain many genes, so a chromosome mutation will effect many genes. A gene mutation will have an effect only on that gene. ...Read more

12

12
Can you tell me, are all brca gene mutations hereditary?

Can you tell me, are all brca gene mutations hereditary?

Good question. : The answer is no, a small number of patients with early onset breast cancer who carry a bad brca 1 or 2 mutation develop it "de novo", meaning that it started with them (after all, someone has to be the first to have it). Depending at which stage in development it happens, it may affect them to a different degree and may or may not be passed to their children. Some other cancer syndromes.. ...Read more

See 1 more doctor answer
14

14
Will stem cell therapy ever help kids with trisomy?

Will stem cell therapy ever help kids with trisomy?

No: With any trisomy every cell in the body has an extra chromosome in the nucleus.That extra chromosome interferes with the normal information that tells each metabolic function how to proceed. Those trisomy's that are compatible with a rather normal life have less interference shown than others, but stem cells would never cancel or remove the extra chromosome. ...Read more

See 1 more doctor answer
15

15
Can comprehensive chromosome screening (CCS) in IVF screen for (1) partial trisomy, (2) unbalanced translocation, and (3) balanced translocation? Does testing parental karyotyping before CCS help?

Can comprehensive chromosome screening (CCS) in IVF screen for (1) partial  trisomy, (2) unbalanced translocation, and (3) balanced translocation? Does testing parental karyotyping before CCS help?

Test for Aneuploidy: Aneuploidy is the term used to describe any embryo with either too many or too few chromosomes. It is the cause of greater than 60% of miscarriages, as well as the most likely reason that patients do not get pregnant from an IVF cycle. The purpose of CCS is to analyze, select and transfer only embryos that do not have abnormalities in their number of chromosomes. A genetic consult is needed; ...Read more

17

17
With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter , DNA mutation (mthfr, a1at ...) methylation etc.

Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients. ...Read more

See 4 more doctor answers
18

18
What are pros and cons of genetic engineering such as stem cell research, cloning?

What are pros and cons of genetic engineering such as stem cell research, cloning?

Controversial: Significant moral and scientific controversies in use of genetic engineering and cloning. Limited experience in the long-term outcomes make both issues limited to laboratory and animal studies. ...Read more

19

19
Gene expression profiling predicts clinical outcome of breast cancer?

Gene expression profiling predicts clinical outcome of breast cancer?

We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more

20

20
Can gene therapy help with mitochondrial disorders?

Not yet: To date I have not heard of gene therapy applicable to mitochondrial disorders. ...Read more

Gene (Definition)

A hereditary unit consisting of a sequence of dna that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their ...Read more


Dr. HARRY OPSIMOS
1,104 doctors shared insights

Gene Therapy (Definition)

Genes are the hereditary units of DNA. Gene therapy is a new area of research in which individuals with genetic diseases can be treated by the insertion, modification, or removal of ...Read more