Doctor insights on:
Gene Therapy For Color Blindness
In theory yes: As sickle cell anemia is a genetic disease, correction of the gene defect by stem cell transplantation or gene therapy would theoretically correct the genetic defect. Gene therapy is experimental at this time. Stem cell transplantation is more common, but is limited by the availability of suitable tissue matched donors. In either case, correction of the genetic defect will not fix prior strokes. ...Read moreSee 1 more doctor answer
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Nearsightedness is a recessive trait. red-green color blindness is a sex-linked recessive trait, what does this mean?
An Autosomal: Recessive disorder: Both parents are unaffected carriers of a mutant gene. Each of their children has a 25% chance of inheriting the mutant gene from both & having the disorder. X-linked recessive: Mom carries a defective gene on one of her X chromosomes. Each son has a 50% chance of inheriting the X chromosome with the mutant gene & having the disorder; each daughter, 50% of being a carrier. ...Read more
Sex linked: The most common form is carried on the X chromosome and so it manifests more commonly by far in males who lack a corresponding X (as women do ) to compensate (males have a sort Y chromosome). It is therefore passed on to a male child from his mother who carries a defective X (and most likely a normal X matching it so she is not color deficient.). ...Read more
Gene therapy for HIV: Gene therapy for HIV could be coming. A company called sangamo pharm. Has developed a gene modification tool called a zinc-finger endonuclease that can alter on of the lymphocyte genes that allows HIV to enter the cells; called a chemokine receptor. They are involved in clinical studies at this time that look promising. ...Read more
It varies: Retinitis pigmentosa, or rp for short, can be caused by mutations in about 3 dozen different genes. Depending on the gene involved for a particular family, the inheritance can be dominant, recessive, x linked, digenic, or mitochondrial. Complicated! your family history and a thorough medical evaluation are the most important tools for figuring out the inheritance pattern what genes to test. ...Read more
Yes: Mutations in one of these several genes will cause colorblindness. These are autosomal recessive mutations. The genes are: achm2-alpha subunit of the cone photoreceptor cgmp-gated cation channel, on chromosome 2q11; achm3- cngb3 gene, the beta subunit of the cone cyclic nucleotide-gated cation channel, on chromosome 8q21; achm4- gnat2 gene, Alpha subunit of cone transducing, on chromosome 1p13. ...Read more
Please advice about the following therapy for thalassemia purpose-
Bluebird Bio Gene Therapy
When the therapy will be available?
Yes: Cell therapy generally involves stem or pluripotent cells that have the potential, under the right triggers, to grow into many different types of cells. These cells are then transplanted to an area of disease. Gene therapy generally involves replacing small dysfunctional segments of dna. Dna is present in almost every cell in our body and is the instruction manual that tells the cell what to do. ...Read more
What are you asking?: Can you clarify? Genetic testing for DNA isn't subject to much in the way of outside influences. Genetic work on colorblindness is available but we're not sure what to do with the data. The former is life-and-death. The latter is perhaps a target for gene therapy that will give fullcolor vision to those who haven't enjoyed it. ...Read more
Unrelated: These are products of abnormal genes acting upon an entirely separate system within the body. They can occur together but are not related in any way. ...Read more
No and yes: Safe effective gene therapy for CF is a dream that we have yet to realize, but there are many excellent CF centers in the us. The CF foundation is an excellent source of information on these centers. The treatments for CF are improving, and expanding constantly. The life expectancy for patients with CF has steadily increased but is still limited by pulmonary disease. ...Read more
My father is suffering from retinitis pigmentosa(RP). Is there any new treatment available to cure RP in USA?
RP: no new treatments are currently available but lots of research is being currently being conducted ...Read more
Mutations (changes) : Changes in genes (regulatory elements) in every cell are inherited and may affect color vision. Thede changes are statistically much more significantt in males than females because the latter often have normal color vision genes to compensate. Inhered color blindness thus is more common in males, but color deficit also can result from some eye diseases, in either sex. ...Read more
Ophthalmologist prefer to use the term color deficit as blindness conveys other meanings. Lowered color perception can be inherited (many forms), can result from advanced loss of retinal cells, inherited retinal disease, and some forms occur due to CNS injury. There are excellent tests for the various types and they can be functionally ...Read more
Vision impairment and blindness are conditions in which a person cannot see well or see at all, even with glasses or contact lenses. If a person's best vision (with correction) out of either eye is only 20/70 - 20/200, he is impaired. If he can see no better than 20/200 or his visual field is no more than 20 degrees (severe "tunnel" vision), ...Read more