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Doctor insights on: Gemzar Herceptin

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Want to stay on herceptin (trastuzumab) and switch from Taxol to gemzar. What is the difference?

Want to stay on herceptin (trastuzumab) and switch from Taxol to gemzar.  What is the difference?

Less neuropathy: Unlike taxol, (paclitaxel) gemcitabine does not cause neuropathy. It can cause low platelets. It can also cause fluid retention. Also it is usually given 2 weeks on and 1 week off. Unlike Taxol (paclitaxel) which typically is given weekly. That is about it in regards to the difference. Hope this helps. ...Read more

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Dr. Michael Kleerekoper
56 doctors shared insights

Trastuzumab (Definition)

Trastuzumab is an antibody based agent which is a kind of ...Read more


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What are trastuzumab and herceptin?

What are trastuzumab and herceptin?

Biologic Therapy: Herceptin/trastuzumab is an antibody to a cell surface proteint coded for by the her2neu gene. Its present in some normal cells but in a subset of breast cancers (10-15%) there are multiple copies of the gene producing large amounts of the protein. The herceptin/trastuzumab antibody binds to that protein and reduces that aggressive nature of her2+cancer. It is usually given with chemo. ...Read more

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What are the effects of herceptin (trastuzumab)?

What are the effects of herceptin (trastuzumab)?

Killing cancer cells: Herceptin (trastuzumab) is an antibody, which is the y-shaped green thing in the picture. It sticks to the her2 protein which is present on some breast cancers (and other cancers). Herceptin (trastuzumab) seems to help the body's immune cells "see" and attack the cancer cells. For women with her2 positive breast cancer, it decreases the risk of the cancer returning by almost 50%! ...Read more

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What is Gemzar (gemcitabine)?

What is Gemzar (gemcitabine)?

Gemzar (gemcitabine): "Gemzar is used to treat cancers of the pancreas, lung, ovary, and breast. See: http://www.drugs.com/gemzar.html ...Read more

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What causes herceptin (trastuzumab) headache?

What causes herceptin (trastuzumab) headache?

Let me explain: The thoery is Herceptin (trastuzumab) infusion cause contious vasodilatation which is thought to provoke the headache. ...Read more

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What side effects are associated with Gemzar (gemcitabine)?

Gemzar (gemcitabine): See: http://www.drugs.com/sfx/gemcitabine-side-effects.html

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How long should I wait to get pregnant after herceptin (trastuzumab)?

Maybe 60 days or so : Herceptin (trastuzumab) has been reported to be associated with oligohydramnios (scant amniotic fluid) during pregnancy but there are also reports of normal fetuses born even in women who received Herceptin (trastuzumab) sometime during pregnancy. The half-life of Herceptin (trastuzumab) is about 12 days. After 5 half-lives (60 days) hardly any drug should be left in the body. However, check with your doctor before planning any pregnancy. ...Read more

Dr. Andrew Seibert
12 doctors shared insights

Gemcitabine Hydrochloride (Definition)

Gemcitabine hydrochloride ...Read more


Dr. James Lin
62 doctors shared insights

Herceptin (Definition)

Herceptin ...Read more