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Doctor insights on: Gastrin Level

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Particular mechanism that increases the gastrin level?

Particular mechanism that increases the gastrin level?

Acid feedback loop: Gastrin is a hormone that responds to the amount of stomach acid produced--not enough acid causes gastrin levels to rise to stimulate acid production. Gastrin is suppressed when acid levels are adequate in normal patients. However, in those with hypersecretory states like zollinger-ellison syndrome, gastrin is continually produced in high concentration resulting in excess acid, diarrhea, ulcers. ...Read more

Dr. Ralph Wharton
32 doctors shared insights

Gastrin (Definition)

Gastrin is a protein hormone released by special cells called g cells. This hormone stimulates the ...Read more


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If i stop taking my Prilosec will my gastrin levels return to normal permanently ?

If i stop taking my Prilosec will my gastrin levels return to normal permanently ?

No: I am going to assume you've been found to have an elevated gastrin level and this is causing you to make extra stomach acid. The Prilosec will help protect your stomach from the gastrin. This isn't a forum to evaluate a complete history, but if you have a gastrinoma, there are often additional ways to manage it though Prilosec is a good start. Stay proactive and good luck. ...Read more

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Was on high doses of ppi's now high gastrin levels, achlorhdria and gastroparesis - could they be linked?

Was on high doses of ppi's now high gastrin levels, achlorhdria and gastroparesis  - could they be linked?

Yes, mostly: The purpose of a PPI is to stop the production of hydrochloric acid.. Achlorhydia is the abscence of that acid. So the answer is yes. Gastrin stimulates acid production, so when the PPI blocks it's production, the body reacts by producing more gastrin trying to overcome the effect of the PPI. Both these can resolve after PPI is stopped or dose decreased. Gastroparesis is not related to PPI. ...Read more

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If you have a pituitary tumor and high gastrin levels but an octreoscan came back negative, what is likely wrong?

If you have a pituitary tumor and high gastrin levels but an octreoscan came back negative, what is likely wrong?

There is a condition: Called men (multiple endocrine neoplasia) that can be associated with pituitary tumors, gastrin producing tumors (and other tumors of the pancreas) and parathyroid tumors. It is caused by a certain gene mutation. Things to consider-1. If you are on a proton pump inhibitor, that can raise your gastrin level. 2. Octreotide scans are not the most sensitive imaging technique, and may miss some tumors. ...Read more

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I have constant diahrria , high thyroid levels, extremely high gastrin levels, and pernicious anemia , plus my gallbladder removed .What is wrong ?

I have constant diahrria , high thyroid levels, extremely high gastrin levels, and pernicious anemia , plus my gallbladder removed .What is wrong ?

Easy diagnosis but: I do not want to give your disease one label. You could have more than one disease. Pain or heart burn?High thyroid needs treatement. Diarrhoea related to thyroid and/or high gastrin? Gastrin and pernicious anemia could be connected. During gall bladder surgery, what did the surgoen and pathologist report? A cancer doctor could easliy help you, hope that you know answer soon? The sooner, better. ...Read more

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Gastrin level 138, EGD showing small stomach inflammation, colonoscopy normal, . Lots of burning sensation, thirst, and ear ringing. What to testfor?

Gastrin level 138, EGD showing small stomach inflammation, colonoscopy  normal, . Lots of burning  sensation, thirst, and ear ringing. What to testfor?

Talk to your GI: Gastrin of 138 is higher than expected normal but it's not severely high. It can be elevated due to just gastritis (inflammation of the stomach). The gastroenterologist likely tested for things while doing the EGD such as testing for h.pylori and taking biopsies. ...Read more

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