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Doctor insights on: Gamma Globulin Anemia

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What causes pernicious anemia and a mild increase in gamma globulin?

What causes pernicious anemia and a mild increase in gamma globulin?

Pernicious anemia...: Is due to B12 def arising from loss of intrinsic factor production by parietal cells in the stomach and required for B12 absorption in the gut. Anything that produces B12 def can cause these symptoms. Classically, pa is one such diagnosis that is due to destruction of parietal cells by the immune system (ie., an autoimmune disorder). I suspect elevated igg is true, true and unrelated. See your dr. ...Read more

Dr. Steven Ginsberg
1,239 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more


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I have inconsistent tests that lean toward multiple myeloma or MGUS. First xray lytic lesion; globulin series serum & urine monoclonal positive to gamma; 24 hr electopherurine neg; beginning anemia; BUN off; other small abnormals. Bone survey neg.

I have inconsistent tests that lean toward multiple myeloma or MGUS. First xray lytic lesion; globulin series serum & urine monoclonal positive to gamma; 24 hr electopherurine neg; beginning anemia; BUN off; other small abnormals. Bone survey neg.

Need second opinion: The criteria for myeloma vs Mgus changed recently but both changes include exact percentages and size of lytic bone lesions. Your data as you summarized are not adequate and since mgus vs multiple myeloma are like dawn and day, you need to be seen and your precise numbers verified. That said, please see hemeonc in centers experienced in myeloma dx,management,and treatment. ...Read more

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What is immune gamma globulin treatment?

What is immune gamma globulin treatment?

Antibody replacement: Combined antibody from a pool of healthy donors is given to patients who either do not make antibody for themselves or cannot make specific antibody against a pathogen. The product is also given in the context of several hyperinflamatory or autoimmune disorders because the pooled antibody either blocks the activity of rogue/autoimmune antibodies or downregulates overactive white blood cells. ...Read more

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Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

No: Very unlikely, unless the patient is already immune compromised, other causes for this low level would be diseases/disorders leading to loss of protein from gut, kidneys or malnutrition, are mainly the causes for such, low level of immunoglobulins has other causes in addition,mainly lymphocytes problems, either T cells or B cells problems mainly are the causes for immunodeficiency states 1ry / 2ry ...Read more

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Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Lo gamma globulins: Well that isn't an isolated number, meaning it should be interpreted in the context of a clinical picture, so why did you have this done and repeated in the first place? Several reasons for such, mainly protein losing disorders either from a gut or from kidneys, malnutrition/ primary immunodeficiency can be a cause too, replacement therapy available,but you need to be rightfully diagnosed,goodluck ...Read more

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I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

Maybe: Reference ranges are set so that several percent of healthy folks fall outside on either side. This may just be you. It is no danger. Stop worrying. If this continues or you are very curious, you can get the various types quantitated. Some folks run way-low on one of the three major types. Usually they still do okay. ...Read more

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Recently I had lab work done. My globulin level was 5.8. My dr did further testing and total globulin was 4.9. My gamma globulin was a little elevated?

Recently I had lab work done. My globulin level was 5.8. My dr did further testing and total globulin was 4.9. My gamma globulin was a little elevated?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have helped to have the actual results. Elevated gamma globulins may indicate the presence of inflammation. ...Read more

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Gamma globulin level in test is 22.6%, results page they gave says this is higher than normal, normal range is listed as 11.1-18.8%. Concerned Myeloma?

Gamma globulin level in test is 22.6%, results page they gave says this is higher than normal, normal range is listed as 11.1-18.8%. Concerned Myeloma?

Means nothing: Reference ranges are set so that several percent of healthy folks fall outside on either end. This has actually happened to me as well. At age 27 you do not have myeloma, and even myeloma patients usually suppress the other gamma globulins. ...Read more

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What are gamma globulin injections?

What are gamma globulin injections?

Gamma globulin: Igg, gamma globulin is a protein for some one elses immunity to a disease. It is passive, and usually gone in 3-6 months. It can protect you from the said disease for a short period of time. ...Read more

Dr. Robert Dracker
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Immune Globulin (Definition)

The immune globulins are a class of blood proteins elaborated by the immune system to fight infection, and then remember the antigens of the infecting agent to use for ...Read more