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Doctor insights on: Gaba Supplements That Pass The Blood Brain Barrier

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Is magnesium l-threonate the only type of mg that crosses the blood brain barrier? What type of mg would help for GABA receptor upregulation?

Is magnesium l-threonate the only type of mg that crosses the blood brain barrier? What type of mg would help for GABA receptor upregulation?

Not really: Other forms of magnesium get into brain but at lower levels. There is one study in rats, not humans, that shows enhancement of learning & memory with magnesium l-threonate. In the study, the rats drank the compound in water -- 604 mg/kg/day. Of course supplement companies like life extension foundation are happy to sell you preparations of this although there are no clinical studies in humans.

Dr. Randy Baker
2,052 Doctors shared insights

Supplements (Definition)

A dietary supplement, also known as food supplement or nutritional supplement, is a preparation intended to supplement the diet and provide nutrients, such as vitamins, minerals, fiber, fatty acids, or amino acids, that may be missing or may not be consumed in sufficient quantities in a person's diet. Some countries define dietary supplements as foods, while ...Read more


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Do the rabies virus passes the blood-brain barrier?

Do the rabies virus passes the blood-brain barrier?

Rabies: The rabies virus enters the brain by entering peripheral nerves and spreading thruough the nerves to the brain.

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Before the rabies virus passes the blood-brain barrier, how come the body does not destroy it?

Before the rabies virus passes the blood-brain barrier, how come the body does not destroy it?

Only if immune: This will only happen if you have previously been immunized and have antibodies to the virus.

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Why should we pay attention to the blood-brain barrier development?

Why should we pay attention to the blood-brain barrier development?

DISEASE INDICATOR: During intrauterine development, infancy and childhood the brain develops very rapidly. The ability to selectively protect the brain from some blood borne substances is essential. Viral illnesses of the brain can disrupt the blood brain barrier.

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What are the advantages of a drug that can cross the blood brain barrier?

What are the advantages of a drug that can cross the blood brain barrier?

BBB: It can reach its target in the brain to exert effect, such as some antibiotics to treat bacteria in the brain.

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Why can't dopamine cross the blood brain barrier?

Why can't dopamine cross the blood brain barrier?

Biochemistry: Actually this why we give patient Levodopa-Carbidopa together, or SINEMT. Dopamine just as molecule can not, but Levo can. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier.

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How do infections cross the blood-brain barrier?

How do infections cross the blood-brain barrier?

Depends on infection: Some bugs (viruses, bacterias, etc.) are small enough, and if they circulate in blood, can easy cross the barrier, others require trauma or surgery to penetrate the brain.

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How does secondary brain cancer get into the brain? Can it cross the blood brain barrier?

How does secondary brain cancer get into the brain? Can it cross the blood brain barrier?

Yes!: Cabncer cells travel via the blood and can get to the brain just like they do to all other body parts/sites. They are very invasive and are capable of breaking the blood brain barrier easily!

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Between Allegra and Desloratadine, which drug has less blood-brain barrier permeability and is less anticholinergic?

Between Allegra and Desloratadine, which drug has less blood-brain barrier permeability and is less anticholinergic?

Allegra: Fexofenadine and loratadine, allegra and claritin, respectively, are the least sedating of all anti-histamines according to a recent NIH review. All anti-histamines cross the blood brain barrier to some extent. The real issue is sedation and allegra and claritin appear to win the context. They are also less anticholinergic than many others.

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Heard that perfumes contain toxic chemicals capable of remaining in the brain for decades once crossed the blood brain barrier, is this true?

Heard that perfumes contain toxic chemicals capable of remaining in the brain for decades once crossed the blood brain barrier, is this true?

I don't think so: Our world's full of causes, and an understandable fear of "chemicals" has prompted some people to demand a "perfume-free workplace." I don't want to get into any arguments here, but I think most healthtap members will tell you these fears are not evidence-based. The most inflammatory claim about neurotoxicity is a non-peer-reviewed poster. I'll add that I very much dislike artificial fragrances.

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Could you please describe some of the negative consequences that can occur when the blood-brain barrier is weakened?

Could you please describe some of the negative consequences that can occur when the blood-brain barrier is weakened?

Multiple causes: Inflammation due to infection, Multiple Sclerosis, arteritis or vasculitis can cause breakdown of the brain-blood barrier, as can brain hemorrhage and stroke. The outcomes depend on the nature of the causative process. Recommend information from AAN. Com, or the Mayo Clinic site.

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What is the role of the blood brain barrier in cerebral auto regulation?

What is the role of the blood brain barrier in cerebral auto regulation?

Modest role: Central autoregulation responds to carbon dioxide and pH levels, and both blood flow and blood pressure respond based on fluctuations. The brain blood barrier will allow interactions with outside and inside contacts for these situations.

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Could you tell me if there's a blood brain barrier, how do people get metastatic/secondary brain tumors?

Could you tell me if there's a blood brain barrier, how do people get metastatic/secondary brain tumors?

Imperfect barrier.: The blood brain barrier separates circulating blood from the brain proper. The barrier consists of tight junctions in cells lining the blood vessels in the brain as well as a thick basement membrane and processes from astrocytes (structural/supporting brain cells). This barrier helps to limit pathogens (bacteria) and cancers from entering the brain; however, no physiologic system is "perfect".

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Is there an antihistamine you could recommend that would have a very low probability of crossing the blood brain barrier to deter mental impairment?

Is there an antihistamine you could recommend that would have a very low probability of crossing the blood brain barrier to deter mental impairment?

2nd generation: Antihistamines as desloratadine or fexofenadine have much lower probability of crossing to the brain, in recommended daily doses, some people would still be sedated despite the recommended dose, yet to try different formulations to reach the desired effect, safety critical jobs as pilots need to work with their doctors closely, you better see an allergist/immunologist for alternatives, take care

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Do fungal infections cross the blood-brain barrier?

Do fungal infections cross the blood-brain barrier?

They can: While the blood-brain barrier is a critical regulator of interaction between the blood stream and the brain, it cannot keep everything "out". Many infections, including fungal can spread to involve the brain. Some very serious fungal infections commonly involve the brain (central nervous system-cns).

Gaba (Definition)

Gamma-aminobutyric acid (also known as gaba)is used as a supplement ...Read more