Doctor insights on:
2.8 oligoclonal bands IgG in CSF. Zero serum bands in CSF. Why does Mayo Clinic standards require 4 oligoclonal IGg CSF for MS diagnosis?
Other causes: Oligoclonal bands can be present in some other conditions such as infections and inflammation of the central nervous system. Increasing the threshold for diagnosing MS by requiring at least 4 oligoclonal bands, allows to exclude these other causes and diagnose MS with greater certainty. ...Read more
Difficult question: Glycine is an Amino Acid that is the product of normal protein metabolism. Rare cases of inborn errors of metabolism result in a defect in metabolism of certain Amino Acids including glycine. A very rare disorder is non-ketotic hyperglycinemia where the glycine in the CSF is many times normal. The range of normal varies with ingestion of protein and depending on the form of laboratory assay. ...Read more
Many causes: CSF protein results can be high in many conditions. It is best to interpret the results in the context of all the other results of CSF fluid analysis. Some causes are viral meningitis, demyelinatinfg diseases, diabetes, brain abscess, syphillis, brain tumor, alcoholism, and epilepsy ...Read more
Lumbar puncture results:
Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF.
IgG value 9.43, range 6 - 15
Is this MS?
Consistent: But diagnosis of MS should be based on history, physical exam, results of MRI films, and spinal fluid is useful in ambiguous cases. However, elevation of oligoclonal bands can be seen in several disorders and NOT definitive on its own. Have your doctor now put the whole picture in place. Most likely MS, but other possibilities exist. ...Read more
Sonhashydrocephalus with chari II malformation CSF many rbcs wbcs 55/cmm protein 30 mg glucose 50 mg shunt not responding or get blocked will he walk?
Don't know: This answer is too specific. Too many variables. ...Read more
Is there CSF IgG subclass deficiency?
I have lowish IgG and IgG subclass deficiencies (1, 3, 4) and CSF IgG of 685 .
LP Done. Monocytes 1%, Serum IgG 587/mg/DL,Albumin 4100ml,IGG Index 1.1mg,WBC 23/mm3,RBC 1/mm3, CSF IGG 3.6 mg/DL,Lymphocytoid 97%, protein, neutrophils, glucose, CSF albumin all norm. Any ideas?
CSF Results: If I am reading the results correctly, there appears to be a mononuclear pleocytosis with normal protein, glucose and essentially normal immune response. The fluid analysis cn be seen in many disorders including viral meningitis. Need additional information. ...Read moreSee 1 more doctor answer
Leak: They are not usually relatedGet a more detailed answer ›
See an immunologist: Immunoglobulin g (igg) is the main type of antibody found in the blood and is used by your body to help fight off infections. Some people may have a slightly low igg but be perfectly healthy. In others, it may indicate a problem with the immune system that can put one at risk for getting infections. An immunologist can perform additional tests to determine the cause of the low igg. ...Read moreSee 1 more doctor answer
CSF IgG is 2.6, CSF Albumin is 28, CFS IgG/Albumin Ratio is 9%. Could this indicate MS or Lyme Disease if clinically the symptoms fit?
Test results: The IGG Index requires a comparison to the IGG in blood and CSF. It is a nonspecific test for inflammatory diseases like those you referred to. What were the blood levels? A better test for MS is CSF oligoclonal bands. Do you have that? Along with an MRI result? For Lyme disease you would want a CSF ELISA or Western blot for Lyme proteins. Hope that helps. ...Read moreSee 1 more doctor answer
Dizziness, one sided numbness, one sided temp loss of function, uncontrollable body jerks, oligoclonal bands in CSF and serum. Neuro behcets or ms?
Suggest : The oligoclonal bands should be significantly increased in spinal fluid as contrasted to serum to be c/w multiple sclerosis, and some of your problems are likewise supportive of ms. However, do you have history of eye and skin problems more in keeping with behcets, and are MRI studies of both head and neck c/w ms? This should be fairly easy to sort out, and if ambiguous, perhaps a second opinion. ...Read more
?+oligoclonal in csf, + opt neuritis,vep abn,EMG Abn, ocular CT abn,neuro cog test abn. No lesions. ? MS. +s/s- n/t legs,balance,speech.ms imitat.Neg
Clarification: You have multiple issues, and most would strongly implicate MS. But if an MRI of both brain and spinal cord is normal, you do NOT have MS. However, several other possibilities exist, and you need to clarify your diagnosis. May help to obtain another opinion. ...Read moreSee 2 more doctor answers
Iga low, IG subclass 2&4 very low, total IG low, subclass 1&3 low normal. Could prednisone taper 1wk before labs or zonisamide cause these results?
Had two spinal taps.. 1st high opening pressure. 4 o bands, high protien, mild bbb disruption. 2nd 1 band, normal pressure and protein. Significance?
Spinal tap results. Csf beta% raised slighty. Csf albumin raised slighty. Cytology report showed increased immature and mature lymphocytes and monocyt?
Check with oncology: The cytology report is a bit concerning and you need to follow-up with your oncologist. Anytime you see increased lymphocytes in the absence of an infection, you have to watch for lymphoma. Your oncologist should be able to give you more information depending on how increased the lymphocyte # is above the normal for your lab. ...Read more
Low gamma globulin: By itself, a slightly low level of one igg subclass is a very nonspecific finding. A very low level would be worrisome, but really, what is needed is to look at this information in the context of vaccine responses to Pneumovax vaccine. If the functional antibodies made by the immune system are at normal levels, the gross levels of antibody are less worrisome. ...Read more
Wiki says B12 injections can cause transient drop in k levels through rapid intake of k into RBC production. Hypokalemia. T or f?
"Anecdotal": And transient. And only reported when people are severely deficient. A B12 injection in someone gravely sick from pernicious anemia causes a massive rebound in the marrow, with as much as a pound of new vital blood-forming in a few days. Why extra k is required at the time. This has been misrepresented by "pop" amateur doctors. I'm glad you're skeptical about internet distortions. Best wishes. ...Read moreSee 1 more doctor answer
Can you explain my lumbar puncture results - CSF alpha Feto protein 0.555 Beta HCG 0.322(iu/l) I have a pineal tumour. Tested CSF for germ cell.
These values are OK: These levels do not look out of ordinary. You need to relate these levels to previous levels of these markers. if they were high before then this test might have some meaning. Your oncologist is your best guide to explain what it all means. ...Read more