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Doctor insights on: Folinic Acid Warnings And Recalls

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What's folinic acid?

What's folinic acid?

Leucovorin: Essentially a vitamin but a reduced form of folic acid. Commonly used in combination with certain chemotherapy drugs when treating cancer. In colon cancer it is used because the tumor is deficient in folinic acid so by replacing it, the chemo works better. When using high dose methotrexate, you have to use this called leucovorin rescue, otherwise the side effects are terrible. ...Read more

Dr. Brad Goldenberg
22 doctors shared insights

Leucovorin (Definition)

Leucovorin is an anti-cell breakdown agent which is a ...Read more


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My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For 1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For  1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

Folic acid ok!: She will do fine with the folic acid! 10mg of mtx is a low dose. By the way, recent paper suggested that the drugs your mom takes very effective for ra. Just read it today! ...Read more

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What are Leucovorin injections used for?

Leucovorin injection: "Leucovorin calcium rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Leucovorin calcium is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists. Leucovorin calcium is indicated in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy > ...Read more

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Who should not use Leucovorin injections?

Leucovorin injection: "Leucovorin is improper therapy for pernicious anemia and other megaloblastic anemias secondary to the lack of vitamin B12. A hematologic remission may occur while neurologic manifestations continue to progress." See: http://www.drugs.com/pro/leucovorin-injection.html ...Read more

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If I take 5 fu / leucovorin, should I not take B12?

Yes Avoid it for now: Since you are taking chemotherapy, we would discourage you from taking any Vitamins or antioxidants as they can interfere with the benefit of chemotherapy. ...Read more

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Do you need a prescription for Leucovorin injections?

Leucovorin: The injection is prescribed. See: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608038.html

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Should cytoxan, fludara, (fludarabine) leucovorin be taken together?

Should cytoxan, fludara, (fludarabine) leucovorin be taken together?

Porbably not: The combination of chemotherapy is dependent on the disease being treated. The drugs you mention are not generally given in combination together. ...Read more

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How effective are Leucovorin injections for treating colon cancer?

How effective are Leucovorin injections for treating colon cancer?

Not anti tumor: Leukovorum is used as an adjuvant or modifier of single or combinations of chemotherapeutic agents. It helps to prevent the toxic side effects of a number of chemotherapeutic agents including methotrexate. It also can be used to treat anemia caused by a lack of folic acid. It is added to combination of drugs employed in the supportive care of patients with colon cancer but does not have anticancer effects on diseases such as colon cancer, . ...Read more

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For the past 5 days i've been vomiting food, water, and stomach acid multiple times a day. It comes with little warning and i cant control it.

For the past 5 days i've been vomiting food, water, and stomach acid multiple times a day. It comes with little warning and i cant control it.

Need an EGD: Don't know your age. If older, If this is not now resolving /resolved - suggesting a stomach flu - you will then assuredly need an EGD by a gastroenterologist and maybe even a CT scan of the abdomen. For something like this, it either self resolves quickly or you need a work-up by an internist (blood tests and urine tests) and a referral to a gastroenterologist. ...Read more

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I sing all the time. After warning up today my throat started burning really badly. I'm on omeprazole for acid reflux. What could this be? A hemorage?

I sing all the time. After warning up today my throat started burning really badly. I'm on omeprazole for acid reflux. What could this be? A hemorage?

Possibly: Did your voice change with this burning sensation? If not, it's not likely a hemorrhage. Any burning from reflux should have felt like, well, reflux. If your voice did change with this, you need to rest it fora few days, and it would help to have it examined by an ent. It might be nice to see someone who specializes in voice problems, but most ent's could help with this. ...Read more

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Blood test showed folic acid level that my doc said was "higher than he thought was possible". I can't recall exact numbers. Should i be concerned?

Blood test showed folic acid level that my doc said was "higher than he thought was possible". I can't recall exact numbers. Should i be concerned?

No need for concern: High Folic Acid levels either indicate that you are taking a lot of Folic Acid through your diet and/or vitamins or you cannot process Folic Acid and so it builds up to high levels in the blood. This can be due to a genetic abnormality called mthfr, which can be tested through a regular blood test. Treatment is usually a different form of Folic Acid called methylfolate along with methylb12. ...Read more

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What is the early warning signs of kidny failure?

What is the early  warning  signs of kidny failure?

Kidney failure: Many times there are no early signs. One sign to watch for is leg swelling and fluid retention. A blood test can detect poor kidney function. Consult a doctor. ...Read more

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What are the warning signs of type I diabetes?

What are the warning signs of type I diabetes?

See below: Early signs and symptoms of diabetes include increased urination, increased thirst and weight changes. Diabetes can only be diagnosed by a physician though. ...Read more

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What are the warning signs that a stroke is coming?

What are the warning signs that a stroke is coming?

Stroke / TIA: Two type of stroke: hemorrhagic (bleeding) stroke ischemic (non-bleeding) stroke common symptoms: speech difficulty loss of speech double vision focal weakness focal numbness imbalance memory loss facial weakness (abnormal face). ...Read more

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What are considered the common warning signs that you might have diabetes?

What are considered the common warning signs that you might have diabetes?

Multiple: Frequent urination unusual thirst extreme hunger unusual weight loss extreme fatigue and irritability frequent infections blurred vision cuts/bruises that are slow to heal tingling/numbness in the hands/feet recurring skin, gum, or bladder infections. ...Read more

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What are the warning signs of cfs?

What are the warning signs of cfs?

Fatigue: With our polluted environment and poor diets this has become a common issue! find a functional medicine doc in your area at a4m.Com using doc locator function. They can help you find cause of your cfs - usually environmental toxins, food allergens, and metabolic derangements. Then you can live a normal life rather than take meds that just mask symptoms and cause side effects! it is treatable! ...Read more

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What are warning signs of meningitis?

What are warning signs of meningitis?

Do you mean symptoms: Fever, headache, increased sensitivity to light and sound, stiff neck, nausea and vomiting, changes in thinking, level of consciousness, and so on. If you think you are getting meningitis go see a doctor asap instead of trying to diagnose yourself. ...Read more

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What are warning signs of male anorexia?

What are warning signs of male anorexia?

The same: The signs of anorexia are the same for men and women. Essentially, it is denying oneself of nutrition, losing weight so that you are well below a healthy weight for your height, both coupled with the belief that you are not thin enough. Anorexia can be a very serious condition. Other things can cause a poor appetite and weight loss, such as depression or a medical problem. Hope this helps. ...Read more

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What are the warning signs for concussion?

What are the warning signs for concussion?

Concussion: Concussions typically can occur after a head injury. It doesn't have to be a severe head injury or have loss of consciousness. It depends on the severity of the injury. The symptoms can include headache, dizziness, vision change (blurred vision/ double vision), nausea/vomiting. If your symptoms or headache are severe, or if you have a loss of consciousness, you should get evaluated immediately ...Read more

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