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Doctor insights on: Folinic Acid Warnings And Recalls

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What's folinic acid?

What's folinic acid?

Leucovorin: Essentially a vitamin but a reduced form of folic acid. Commonly used in combination with certain chemotherapy drugs when treating cancer. In colon cancer it is used because the tumor is deficient in folinic acid so by replacing it, the chemo works better. When using high dose methotrexate, you have to use this called leucovorin rescue, otherwise the side effects are terrible. ...Read more

Dr. Brad Goldenberg
22 doctors shared insights

Leucovorin (Definition)

Leucovorin is an anti-cell breakdown agent which is a ...Read more


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My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For 1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

My mom, 60, is on methotrex 10 mg per week and leflunomide 10 mg/day for her r.A. For  1 year. Does she require folinic acid or is folate (folic acid) 5mg/day ok?

Folic acid ok!: She will do fine with the folic acid! 10mg of mtx is a low dose. By the way, recent paper suggested that the drugs your mom takes very effective for ra. Just read it today! ...Read more

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What are Leucovorin injections used for?

Leucovorin injection: "Leucovorin calcium rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Leucovorin calcium is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists. Leucovorin calcium is indicated in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy > ...Read more

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Who should not use Leucovorin injections?

Leucovorin injection: "Leucovorin is improper therapy for pernicious anemia and other megaloblastic anemias secondary to the lack of vitamin B12. A hematologic remission may occur while neurologic manifestations continue to progress." See: http://www.drugs.com/pro/leucovorin-injection.html ...Read more

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If I take 5 fu / leucovorin, should I not take B12?

Yes Avoid it for now: Since you are taking chemotherapy, we would discourage you from taking any Vitamins or antioxidants as they can interfere with the benefit of chemotherapy. ...Read more

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Do you need a prescription for Leucovorin injections?

Leucovorin: The injection is prescribed. See: http://www.nlm.nih.gov/medlineplus/druginfo/meds/a608038.html

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