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Doctor insights on: Folfox Side Effects

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For a 30 year female patient diagnosed with stage iii-b colon cancer, what are the expected specific rather than general side effects of folfox?

For a 30 year female patient diagnosed with stage iii-b colon cancer, what are the expected specific rather than general side effects of folfox?

Depends on person: Folfox is a combination of chemo drugs, including oxaliplatin and Fluorouracil (5fu), and leucovorin and varies a bit by how and when they are given. The side effect profile includes suppression of bone marrow function, neuropathy (numbness or tingling), GI symptoms, fatigue, hair loss, mouth sores, , rash, and others. Individuals will experience varying degrees and types of side effects. ...Read more

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My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?

My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?

Serious diagnosis: Stage 4 colon cancer has a very poor prognosis. No one can give you a life expectancy that is exact. It depends upon her response to the treatment. Some people respond very well. Of all people that have this diagnosis only about 8% of them are still alive at 5 years. But still she could be one of that 8%. I hope she responds well to the treatments. ...Read more

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I had surgery last nov and had a t1n1 tumor (2 mm) at the base of my appendix. I finished 12 treatments of folfox. What are my chances of a cure?

I had surgery last nov and had a t1n1 tumor (2 mm) at the base of my appendix.  I finished 12 treatments of folfox.  What are my chances of a cure?

Probably good: It is unusual to have spread to a lymph node from such a small tumor. I need more information about the surgical procedure and the type of cancer to give a proper opinion about your prognosis. However, with just 1 node involved, and a proper surgical resection and chemotherapy, your outlook is much better than if 4 or more were involved. Your cure rate could be as high as 75 or 85%. Good luck! ...Read more

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Our two different radiologists disagree about Folfox vs. CapeOx for stage III-B CRC for a 30 year old female. We already know about both drugs and their doses, but we can't decide on which drug to use!

Our two different radiologists disagree about Folfox vs. CapeOx for stage III-B CRC for a 30 year old female. We already know about both drugs and their doses, but we can't decide on which drug to use!

Convenience, side fx: Capecitabine causes more diarrhea and can make hands and feet very sore, but you avoid the need for a pump at home which may allowore freedom. The efficacy is equivalent so it depends on what is more important to you. ...Read more

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How soon can a colon re-connection reversal be performed? I finished my last round of chemo on 10/14/2005 with the social medicine program in Mexico. I plan to return to Texas to have this surgery preformed. I was on the FOLFOX regimen. What would cau

How soon can a colon re-connection reversal be performed?  I finished my last round of chemo on 10/14/2005 with the social medicine program in Mexico.  I plan to return to Texas to have this surgery preformed.  I was on the FOLFOX regimen.  What would cau

Colostomy reversal: There is no set time table for the ability to perform a colostomy reversal. It depends on a lot of factors, most importantly how much of the colon was removed, which portions they were, and how your blood counts are doing after your chemotherapy. Whatever surgeon you see in Texas should be able to give you a ballpark date. Best of luck! ...Read more

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My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer.She's on folfox. Life expectancy??

My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer.She's on folfox. Life expectancy??

Varies from months/y: The overall survival of stage 4 colon cancer varies from 1 to 3 years. Most patients have at least 2 years if their tumor responds to chemo. If you tumors regresses after chemo, it may even be surgically removable in which case long term survival(even a cure) can be possible. Ask more questions to your treating oncologist. ...Read more

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My 63 yr old mom w/ colon cancer, stge 4, is on folfox. Multiple chemo's have failed to shrink or slow down the cancer. Is folfox better/any other?

My 63 yr old mom w/ colon cancer, stge 4, is on folfox.  Multiple chemo's have failed to shrink or slow down the cancer.  Is folfox better/any other?

Use Immunochemo: Chemo combination therapy known to have limited activity with recurrence secondary to resistant stem cells. Immunochemo a better choice with use of Avastin, (bevacizumab) Erbotix in combination with chemo such as Gemzar. Newer monoclonal therapy employing derivatives of the post translational modification of the oncofetalprotein MUC5ac now entering Phase III appears to be enhanceing survival interval. ...Read more

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What can my mother expect who has colon cancer and will be on the folfox 4 regimen for chemotherapy?

It depends: Results depend upon the stage of cancer. It is active for the adjuvant treatment and in metastatic disease. The side effects can include nausea and diarrhea. Occasionally there can be some blood count issues. The other side effect can be cold related temporary nerve injury that lasts a very short time. There also is a more long term nerve injury. Most people do tolerate this well. Hope this helps. ...Read more

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What other treatment that folfox for 6 months do you reccomend for someone with a stage 3b colon cancer T4 , n1c without lymph nodes involvement? Any o

What other treatment that folfox for 6 months do you reccomend for someone with a stage 3b colon cancer T4 , n1c without lymph nodes involvement? Any o

Tough one: Well if it is n1, than lymph nodes are positive. If n0 that means lymph nodes are clear or negative. I think folfox 6 months is usually given for stage 3 (lymph node +) disease. Ilook at age, family history, grade of tumor, lvi, oncotype recurrence score if MMR +, perforation or not and if pt really high risk, than 2 years of Xeloda (capecitabine) as risk of relapse is high in first 2 yrs. It is not standard. ...Read more

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