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Doctor insights on: Folfox Side Effects

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For a 30 year female patient diagnosed with stage iii-b colon cancer, what are the expected specific rather than general side effects of folfox?

For a 30 year female patient diagnosed with stage iii-b colon cancer, what are the expected specific rather than general side effects of folfox?

Depends on person: Folfox is a combination of chemo drugs, including oxaliplatin and Fluorouracil (5fu), and leucovorin and varies a bit by how and when they are given. The side effect profile includes suppression of bone marrow function, neuropathy (numbness or tingling), GI symptoms, fatigue, hair loss, mouth sores, , rash, and others. Individuals will experience varying degrees and types of side effects. ...Read more

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My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?

My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?

Serious diagnosis: Stage 4 colon cancer has a very poor prognosis. No one can give you a life expectancy that is exact. It depends upon her response to the treatment. Some people respond very well. Of all people that have this diagnosis only about 8% of them are still alive at 5 years. But still she could be one of that 8%. I hope she responds well to the treatments. ...Read more

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I had surgery last nov and had a t1n1 tumor (2 mm) at the base of my appendix. I finished 12 treatments of folfox. What are my chances of a cure?

I had surgery last nov and had a t1n1 tumor (2 mm) at the base of my appendix.  I finished 12 treatments of folfox.  What are my chances of a cure?

Probably good: It is unusual to have spread to a lymph node from such a small tumor. I need more information about the surgical procedure and the type of cancer to give a proper opinion about your prognosis. However, with just 1 node involved, and a proper surgical resection and chemotherapy, your outlook is much better than if 4 or more were involved. Your cure rate could be as high as 75 or 85%. Good luck! ...Read more

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Our two different radiologists disagree about Folfox vs. CapeOx for stage III-B CRC for a 30 year old female. We already know about both drugs and their doses, but we can't decide on which drug to use!

Our two different radiologists disagree about Folfox vs. CapeOx for stage III-B CRC for a 30 year old female. We already know about both drugs and their doses, but we can't decide on which drug to use!

Convenience, side fx: Capecitabine causes more diarrhea and can make hands and feet very sore, but you avoid the need for a pump at home which may allowore freedom. The efficacy is equivalent so it depends on what is more important to you. ...Read more

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How soon can a colon re-connection reversal be performed? I finished my last round of chemo on 10/14/2005 with the social medicine program in Mexico. I plan to return to Texas to have this surgery preformed. I was on the FOLFOX regimen. What would cau

How soon can a colon re-connection reversal be performed?  I finished my last round of chemo on 10/14/2005 with the social medicine program in Mexico.  I plan to return to Texas to have this surgery preformed.  I was on the FOLFOX regimen.  What would cau

Colostomy reversal: There is no set time table for the ability to perform a colostomy reversal. It depends on a lot of factors, most importantly how much of the colon was removed, which portions they were, and how your blood counts are doing after your chemotherapy. Whatever surgeon you see in Texas should be able to give you a ballpark date. Best of luck! ...Read more

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My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer.She's on folfox. Life expectancy??

My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer.She's on folfox. Life expectancy??

Varies from months/y: The overall survival of stage 4 colon cancer varies from 1 to 3 years. Most patients have at least 2 years if their tumor responds to chemo. If you tumors regresses after chemo, it may even be surgically removable in which case long term survival(even a cure) can be possible. Ask more questions to your treating oncologist. ...Read more

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My 63 yr old mom w/ colon cancer, stge 4, is on folfox. Multiple chemo's have failed to shrink or slow down the cancer. Is folfox better/any other?

Avastin (bevacizumab): Folfox or folfiri seem to be the best agents for advance colorectal cancer. In some patients the addition of Avastin (bevacizumab) can be added in some patients. I would expect her oncologist has discussed these options. ...Read more

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What can my mother expect who has colon cancer and will be on the folfox 4 regimen for chemotherapy?

It depends: Results depend upon the stage of cancer. It is active for the adjuvant treatment and in metastatic disease. The side effects can include nausea and diarrhea. Occasionally there can be some blood count issues. The other side effect can be cold related temporary nerve injury that lasts a very short time. There also is a more long term nerve injury. Most people do tolerate this well. Hope this helps. ...Read more

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What other treatment that folfox for 6 months do you reccomend for someone with a stage 3b colon cancer T4 , n1c without lymph nodes involvement? Any o

What other treatment that folfox for 6 months do you reccomend for someone with a stage 3b colon cancer T4 , n1c without lymph nodes involvement? Any o

Tough one: Well if it is n1, than lymph nodes are positive. If n0 that means lymph nodes are clear or negative. I think folfox 6 months is usually given for stage 3 (lymph node +) disease. Ilook at age, family history, grade of tumor, lvi, oncotype recurrence score if MMR +, perforation or not and if pt really high risk, than 2 years of Xeloda (capecitabine) as risk of relapse is high in first 2 yrs. It is not standard. ...Read more

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Mum has taken the 2nd session of folfox. She was discharged on wed. Today she really feels weak and tired. No diarrhea, no fever but huge headache during night and day. What shall we expect now?

Mum has taken the 2nd session of folfox. She was discharged on wed. Today she really feels weak and tired. No diarrhea, no fever but huge headache during night and day. What shall we expect now?

Chemo side effects : Side effects of chemo include fatigue and headache, but when symptoms are severe, it's always important to contact your oncologist's office and at LEAST discuss it with the nurse and ask her to ask the doctor about it . They might want to check blood counts or have mom come in for an exam , and certainly she needs medication to feel better. Don't suffer in silence, it could be serious! Can't tell! ...Read more

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I had stage iii-b colon cancer and the tumor was removed surgically. I went to 2 oncologists who suggested different chemos: folfox vs. Capeox. I know that folfox is the standard. Does this mean it's better?

Equivalent choices: Capox is really an equivalent regimen to folfox. The difference is that the folfox regimen uses a drug (5- fluorouracil) that is given intravenously via a pump, wile the other regimen utilizes Capecitabine which is an oral version of the same drug which is activated preferentially in the tumor cells. There is a slight difference in the schedule, but these are really considered interchangeable. ...Read more

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Day 3, 1st round folfox regimen for stage iib colon ca. Severe chest pain with eating. Ekg normal, awaiting lab results. Could the chemo cause this?

Day 3, 1st round folfox regimen for stage iib colon ca. Severe chest pain with eating. Ekg normal, awaiting lab results. Could the chemo cause this?

Yes!: The medications in folfox (5-fu, leucovorin and oxaliplatin) can cause gastric reflux. If you are not taking an acid-blocking drug (like Pepcid (famotidine) or prilosec), you might want to ask your doctor if this will help. Another side effect called mucositis causes sores throughout your mouth and throat. Sometimes the mucositis can occur in the esophagus, causing chest pain with eating. ...Read more

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30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

Trust oncologist: 30 yr old stage iii b needs all that is needed to prevent recurrence , both drugs have oxaplatin , folfox has 5 fu & Folic Acid , xelox has Capecitabine , all comparative studies showed almost equal results, please rely and trust your oncologist advise , as therapies are changing so fast for good , will encourage if you want to take a second opinion good luck ...Read more

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My mum, 67 , was diagnosed with colon cancer with liver metastases, lesions in lungs and kidneys. Starting folfox tomorrow?? Life expectancy?

Not enough: Need to assess for Kras and Nras mutation IF she is wild type she should receive FOLFIRI and Erbitux If she has mutation the treatment of choice FOLFOX and Avastin Life expex 22 - 26 months... If responsive disease can be extended with other agents and survival can extend several years. New agents add to OS sequencing of therapy is important to extend Overal survival ...Read more

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My sister is on chemotherapy (folfox for metastatic colon cancer). Recent blood test shows high WBC (14, 000) and platelets (429). Is this okay?

My sister is on chemotherapy (folfox for metastatic colon cancer).  Recent blood test shows high WBC (14, 000) and platelets (429). Is this okay?

No worries.: High WBC can be due to many causes: infection, stress, steroid use, dehydration, or the use of growth factor (such as neupogen). If there is no evidence of infection, then there is nothing to worry about. High platelet count is not uncommon since it is a body's reaction to stress of any cause (platelet is an acute phase reactant). Again, nothing to worry about. All the best, hk. ...Read more

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