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Doctor insights on: Folfiri Erbitux

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How effective is the FOLFIRI chemotherapy regimen for treating colon cancer?

How effective is the FOLFIRI chemotherapy regimen for treating colon cancer?

Some effect: Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. ...Read more

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How effective is the FOLFIRI-Bevacizumab chemotherapy regimen for treating colon cancer?

How effective is the FOLFIRI-Bevacizumab chemotherapy regimen for treating colon cancer?

Moderately useful: FOLFIRI-Bev is the standard, commonly used first line chemotherapy for metastatic Colon cancer. It can add about 12 to 18 months extra to your life such that an average patient can live for 2 to 3 years(some live upto 5-6 years... depending on sites of metastases and their response to chemotherapy. You need tell us more about your history such as dates of diagnosis and treatments/results so far?? ...Read more

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Is folfiri alone effective for metastic colon cancer than irinotecan alone ?

Is folfiri alone effective for metastic colon cancer than irinotecan alone ?

Two drugs vs one dru: Folfiri contains two drugs in the combination: 5-FY(Folinic acid) and Irinotecan. This combination is more effective than using irinotecan alone. It is often combined with Avastin (bevacizumab) in case it is being used to treat colon cancer. ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Who should not use Cetuximab injections?

Who should not use Cetuximab injections?

Cetuximab injections: Although no contraindications were listed by Drugs.Com. there is potential for serious infusion reactions, See: http://www.drugs.com/pro/erbitux.html ...Read more

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How effective are Cetuximab injections for treating colon cancer?

How effective are Cetuximab injections for treating colon cancer?

Some response: Erbitux was one of the first monoclonals develoed. It targets epidermal growth Factor 1 and is used in metastatic colon Ca that has the wild mutated KRAS. The best response is like Herceptin (trastuzumab) where this epidermal growth factor 2 mAb requires added chemo. As such when Colon Ca is treated with Erbitux + chemo there is an improvement in response for a number of months. No cures have been seen. ...Read more

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Is erbitux safe for women who are pregnant or breastfeeding?

Is erbitux safe for women who are pregnant or breastfeeding?

No: Erbitux is a class c medication for pregnancy, meaning it is not considered safe (generally because animal studies have shown adverse fetal effects). It is also considered unsafe for lactation because data suggests high risk of significant adverse effects. Obviously, it is only used in very serious illnesses, but pregnancy should then be avoided and formula feeding would likewise be recommended. ...Read more

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