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Doctor insights on: Focal Segmental Glomerular Sclerosis

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MRI brain results Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

MRI brain results  Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

Covering the bases: That signal that is seen in patients who age is seen very frequently. Most of the time it is what has become known as microangiopathic disease or small vessel disease. Demyelination and gliosis come with a more notable history. Gliosis or scarring and demyelination also produces symptoms that MRI is useful for. Depends on why you had the MRI in the first place. The first entity more common than 2 ...Read more

Dr. Jeffrey Wint
3 doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


Dr. Ashu Syal Dr. Syal
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Please explain: renal cortex contains 29 glomeruli, 13 of which are globally sclerosed. There is focal segmental mesangial hypercellularity.

Dr. Ashu Syal Dr. Syal
2 doctors agreed:
Please explain: renal cortex contains 29 glomeruli, 13 of which 
are globally sclerosed. There is focal segmental mesangial 
hypercellularity.

Sclerosis: So Glomeruli are Filteration units of Kidney. Since kidney's main function is Filteration; the health of glome is directly related to renal function. Sclerosis in layman term means scarring. So 13/29 glomes are scarred. Which means approximately 50% of functional units are scarred or non functional. Mesengial hypercellularity refers to the inflammation in the kidney. Very common with FSGS ...Read more

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Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people. Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more

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What is tubular sclerosis (or tuberous sclerosis)?

What is tubular sclerosis (or tuberous sclerosis)?

Neurological disorde: Tuberous sclerosis is a disorder involving brain structure, skin manifestations and cognitive function. Brain malformations called tubers are characteristic. Skin abnormalities of sebaceous adenomas and subungual fibromas. See a neurologist for more information. ...Read more

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Cure of diffuse renal parenchymal disease?

Kidney: None, all you can do is protect the remaining portion of your kidneys under the care of a nephrologist. ...Read more

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MRI showed moderate supratenatorial white matter disease suspicious of demyelinating process. Multiple nodular foci periventricular Could you explain?

MRI showed moderate supratenatorial white matter disease suspicious of demyelinating process. Multiple nodular foci periventricular Could you explain?

Concern for MS, But: Phyllis, talk to the doctor who ordered the MRI, since he/she can interpret the MRI in the context of the symptoms that brought you to the clinic. In some cases, periventricular white matter lesions are the result of migraines, old head trauma, neuron migration issues, or MS. It is hard to know from just a description of the MRI which is the cause. Good Luck and Stay Healthy! ...Read more

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F,48. Pls detail(1)"nonspec hyperintense FLAIR foci involving L.parietal+bilateral.frontal.lobes" +(2)"signal void along main intracranial vasculature?

F,48. Pls detail(1)"nonspec hyperintense FLAIR foci involving L.parietal+bilateral.frontal.lobes" +(2)"signal void along main intracranial vasculature?

Radiology terms: This is specialized radiology terminology and isn't helpful by itself. The radiologist should provide a conclusion at end of report as to what it all means. This must then be interpreted in context of what symptoms led to study in first place. Too much for any of us to answer in this format. Talk to the doctor who ordered the study. Good luck. ...Read more

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Abnormal FDG activity involving pleural thickening in Rt lower lateral lung base compatible with inflammatory VS early neoplasticism disease. Meaning?

Abnormal FDG activity involving pleural thickening in Rt lower lateral lung base compatible with inflammatory VS early neoplasticism disease. Meaning?

Pleural thickening: It means that the pleural thickening is metabolically active(i.e. It is not chronic scarring, which would be inactive). The 2 main possibilities for this, as you mention, are an active inflammation, which is benign, or neoplastic disease(tumor). Speak with your doctor. If the answer is not clear based on your entire clinical picture, biopsy could be needed to determine what it is. ...Read more

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Attenuation of hep parenchyma. Diffuse capsular enhancement and focal capsular retraction on liver ct. No focal lesions. Could sle serositis cause ?

Attenuation of hep parenchyma. Diffuse capsular enhancement and focal capsular retraction on liver ct.  No focal lesions.  Could sle serositis cause ?

Possibly, but: Possibly, but I am unfamiliar with such a liver effect. Perhaps fibrosis from an associated disease, such as retroperitioneal fibrosis? ...Read more

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What is diffuse renal parenchymal disease?

What is diffuse renal parenchymal disease?

Kidney Disease: "diffuse" means all over the kidney, "parenchymal" means the solid part of the kidney that filters the liquid waste products out of the blood, and "disease" means something is wrong. Typically "diffuse parenchymal disease" means an overall medical problem with the kidney, such as diabetic nephropathy, or post-streptococcal nephritis. In the pediatric world we use this term slightly differently. ...Read more

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Help me interpret vulvar biopsy. Focal squamous atypia. Ki-67 shows mild increase cell proliferation focal vin can't be excluded. Lichen sclerosis?

Nothing serious yet: This report suggests slightly abnormal changes (atypia & increased cell proliferation) which can be a reaction to irritation but there is no definitive evidence of precancerous change (VIN). In short there is nothing to worry about right now unless you are concerned and you'd like a second opinion ...Read more

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Result for my brain MRI -asymmetric decreased attenuation in the left basal ganglia, variant dilated perivascular spaces or punctate chronic lacune. ?

Result for my brain MRI -asymmetric decreased attenuation in the left basal ganglia, variant dilated perivascular spaces or punctate chronic lacune.  ?

MRI report: This is language used in radiology to describe what they see. Ordinarily, they cannot distinguish a small stroke (lacune) from a perivascular space. A "puntate lacune" though is very small. It is probably just the side view of a blood vessel (aka perivascular). Do you smoke? Do you have high blood pressure? Do you have diabetes mellitus? Atrial fibrillation? These are stroke risk factors. ...Read more

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MRI scan shows two small focal flair hot spots in either frontal lobes subcortically. Mild peri ventricular gliosis. Age related mild diffuse atrophy.

MRI scan shows two small focal flair hot spots in either frontal lobes subcortically. Mild peri ventricular gliosis. Age related mild diffuse atrophy.

Probably not...: ...significant. A few small lesions can be seen in many patients without an underlying problem. If there is any concern, then a repeat MR in 4-6 months can be performed. Without any interval change, then you should not worry. However, atrophy at your age is more worrisome and not common, and your Doctor should examine you closely for any underlying cause. ...Read more

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Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

Skin biopsy result: superficial to mid dermal perivascular lymphocytic infilitrate with focal basal vacuolar changes.does thismean allergic vasculitis?

No: There is no involvement of the blood vessels themselves- thus not vasculitis by definition. This is a very common skin biopsy finding which has no diagnostic meaning other than ruling out a more serious condition. ...Read more

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Cellular focul segmental glomular sclerosis is it curable? And what is the prognosis?

Cellular focul segmental glomular sclerosis is it curable? And what is the prognosis?

Need data: Is it primary or secondary fsgs. In addition how much protein is in the urine and what is the current kidney function? If the kidney function is significantly depressed the prognosis is poor. If there is more than 4000mg protein in the urine the prognosis is poor. Primary fsgs has a worse prognosis than secondary fsgs. Follow up with a nephrologist for appropriate treatment. ...Read more

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Are Few tiny scattered nonenhancing T2/T2 FLAIR hyperintensities involving periventricular/ subcortical Zones supratentorial compartment bilat normal?

Are Few tiny scattered nonenhancing T2/T2 FLAIR hyperintensities involving periventricular/ subcortical Zones supratentorial compartment bilat normal?

MRI: You can talk to your doctor about what this finding means in the context of your clinical picture, but usually what you are describing is an incidental, age-related finding that is probably of not much concern. ...Read more