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Doctor insights on: Fluoxetine

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Dr. Heidi Fowler
1,037 doctors shared insights

Fluoxetine (Overview)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better tolerated than previous antidepressants.


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What is Prozac (fluoxetine)?

What is Prozac (fluoxetine)?

SSRI antidepresant : Its been around a while now, but pretty revolutionary when it first came out. It is a selective serotonin reuptake inhibitor most commonly used to treat depression. The ssris were a big step forward due to far less side effects than the tricyclic antidepressants that were the main treatment for depression prior to that. ...Read more

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Dr. Heidi Fowler
1,037 doctors shared insights

Fluoxetine (Overview)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better tolerated than previous antidepressants.


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Please describe the medication: fluoxetine?

Please describe the medication: fluoxetine?

Milestone Medication: Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better tolerated than previous antidepressants. ...Read more

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My doctor took me off clozapine cold turkey. He said he won't prescribe that if the fluoxetine works well. What am i to expect regarding withdrawal?

My doctor took me off clozapine cold turkey. He said he won't prescribe that if the fluoxetine works well. What am i to expect regarding withdrawal?

Variable: The answer depends on how much you were taking and how long you were taking it. Typically, a temporary episode of mild agitation and possibly insomnia will occur but dissipate within 2-4 weeks. You may experience nothing. However, it is best not to take if not absolutely necessary. Don't believe your doctor would have stopped it if he/she thought it would seriously harm you. ...Read more

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Is it dangerous if i was prescribed 40mg of fluoxetine (prozac) , but i've been taking 60mg?

Is it dangerous if i was prescribed 40mg of fluoxetine (prozac) , but i've been taking 60mg?

Probably not: This is probably not dangerous. However, I do not know the basics of your condition. One should never adjust their medications without consulting their doctor. ...Read more

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Is it okay to use fluoxetine (prozac) while on the Depo-Provera shot?

Is it okay to use fluoxetine (prozac) while on the Depo-Provera shot?

Yes: Depo-provera is a great contraceptive for short term (2 years or so), but it can cause some side-effects. It may cause a depression or worsen a pre-existing depression. Prozac (fluoxetine) (or any ssri) is safe to use with depo-provera. ...Read more

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Can the antidepressant fluoxetine used in the treatment of menopause?

Can the antidepressant fluoxetine used in the treatment of menopause?

Yes: Its used for pms with a medical indication and therefore might also be helpful with some of the mood symptoms of menopause. ...Read more

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How effective is fluoxetine in comparison to sertraline & escitalopram?

How effective is fluoxetine in comparison to sertraline & escitalopram?

For what condition?: It's important to know what condition is being treated -- so a good evaluation always comes first. Then helpful medicines can be selected if they're needed. Fluoxetine, sertraline, and escitalopram are all excellent ssri antidepressants with good anti-anxiety effects -- but there are some differences. An individual person may respond to one but not the others. Your psychiatrist can help select. ...Read more

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How does fluoxetine work to change the way I feel?

How does fluoxetine work to change the way I feel?

SSRI: Fluoxetine is one of a category of medications that iselectively increase serotonin levels in the brain by iinhibiting reuptake. Normally when serotonin is released between 2 nerve cells it is taken back into the cell that released it to control the effect. Ssri's prevent this to increase the effect of serotonin. Decreased serotonin in certain areas of the brain plays a role in depression. ...Read more

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How long does it take for fluoxetine to kick in after stoppinc it?

Depends: If the length of time you have not taken fluoxetine has been greater than 2 weeks, then restarting fluoxetine will require 2-4 weeks of taking it regularly for you feel its benefits once again. ...Read more

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How can you safely cut down your dose of fluoxetine?

How can you safely cut down your dose of fluoxetine?

Easily with doc help: Fluoxetine has a 5 day half life in the body, which makes withdrawal problems rare, and tapering not necessary. But do do this with the advice and consultation of your doctor so that you don't risk the return of the symptoms it was helping with. Sometimes you don't realize how much a medication was helping until you lower or stop it. ...Read more

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Do the side effects of fluoxetine get less bothersome the longer I take it?

Do the side effects of fluoxetine get less bothersome the longer I take it?

Yes most do: Most fade as the positive effects kick in--sexual side effects usually don't however. ...Read more

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Should I wait for however long it takes for the citalopram to get out of my system to start fluoxetine?

Should I wait for however long it takes for the citalopram to get out of my system to start fluoxetine?

What did your: physician/ psychiatrist say? No, you don't have to have a drug holiday before changing from citalopram to fluoxetine. ...Read more

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How long does the side effects lasts for fluoxetine 20mg? I've been taking it once a day for 2 days now. I take it for clinical depression & bpd.

How long does the side effects lasts for fluoxetine 20mg? I've been taking it once a day for 2 days now. I take it for clinical depression & bpd.

Borderline PD?: Fluoxetine is a very long-acting medication -- its half-life is 70 hours and that of its main metabolite, norfluoxetine, is 330 hours. This means it will take several weeks to reach steady-state in your system, and that any side effects could take at least a couple of weeks to dissipate. Fluoxetine is usually well-tolerated and can help both depression and aggression common in bordeline pd. ...Read more

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How long should the effects of fluoxetine last?

Unknown: If you are asking how long the medication lasts, the half-life is 72 hours. If you are asking about the overall treatment of depression, it can last a lifetime. ...Read more

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How long do the side effects of fluoxetine last?

Several weeks: The side effects of fluoxetine can last more than 2 weeks, because the drug is transformed into an active metabolite norfluoxetine which takes that long to clear half of it from the body. It takes 1-2 months to clear most of it from the body. It may take longer than 2 months to stop having withdrawal symptoms, especially in the elderly, and those with liver disease or drug-drug interactions. ...Read more

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How long do fluoxetine side effects last? Heard long half life.

Usually 1-2 weeks: The amount of time it takes for side effets to go away is how long it takes certain receptors to change and thus get used to the effect. This is somewhat independent of how long the drug takes to go away, so long as the concentration remains constant. The half life means that the drug stays in the system a long time and is important when mixing other drugs with it. ...Read more

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Why do I bloat when my fluoxetine wears off in evening?

Doesn't wear off: Prozac (fluoxetine) lasts 7-9 days from a single dose, so it doesn't wear off in the evening, your bloating is due to something else. ...Read more

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Should I wait until citalopram is out of my system to start fluoxetine cause it says they can interact or does that mean if they are taken together?

Consult provider: The provider directing this change should advise you on this, but if you must decide on your own - play it as safe as possible. Even for your own ability to evaluate the new drug, it will be clearer if the old one is not clouding the water. But the doctor is responsible and needs to be involved if possible. Best! ...Read more

Dr. Alan Ali
758 doctors shared insights

Prozac (Definition)

Prozac is a serotonin reuptake blocker which is a kind of ...Read more