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Doctor insights on: Fluctuating Ca 125 Recurrence Endometrial Cancer Ovarian

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Dr. Barry Rosen
4,223 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Mom has stg 4 ovarian cancer with recurrence. Is now on avastin (bevacizumab). She feels good, ascetis has gone down, however ca125 has gone from 211 to 3000. Why?

Mom has stg 4 ovarian cancer with recurrence. Is now on avastin (bevacizumab). She feels good, ascetis has gone down, however ca125 has gone from 211 to 3000. Why?

Good question: Why? It is definitely something her oncologist should be concerned about and should try to answer the question. Your mom should get some evaluation done-i.e. Some imaging studies- like ct and or pet scan to answer the question and to see whether Avastin (bevacizumab) alone perhaps is not enough. ...Read more

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7 CM ovarian cyst, ca-125 levels elevated (48), roma score & all blood tests good. Previously had nasopharyngeal cancer. Recurrence or endometrioma?

7 CM ovarian cyst, ca-125 levels elevated (48), roma score & all blood tests good. Previously had nasopharyngeal cancer. Recurrence or endometrioma?

Likely endometrioma: At your age, ovarian cancer would be exceedingly rare. Ca-125 levels can be elevated in young women for a variety of reasons that have nothing to do with cancer. Nasopharyngeal cancer and ovarian have no relation to each other. Your doctor should tell you what features or characteristics the ovarian cyst has, this will tell you what kind of cyst it is. Good luck! ...Read more

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How accurate is ca125 test for ovarian cancer?

How accurate is ca125 test for ovarian cancer?

99% when cancer: Ca-125 is 99% accurate if an ovarian cyst or tumor happens to be cancer. The problem with this blood test is that it is very inaccurate when there is no cancer (called a false positive), sometimes up to 45%. This is why ob/gyns do not use this test as a screening test, or at patient request. ...Read more

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How reliable is the ca125 test for ovarian cancer?

How reliable is the ca125 test for ovarian cancer?

CA 125: Ca 125 is not a reliable test to look for ovarian cancer. It is used in follow up of a woman with ovarian cancer or similar cancers. ...Read more

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Can a woman have a normal ca125 blood test and still have ovarian cancer?

Can a woman have a normal ca125 blood test and still have ovarian cancer?

Ovarian cancer: Yes. Only 85% of ovarian cancers have an elevated ca 12 at presentation. Therefore, 15 of every 100 women with a diagnosis of ovarian cancer have a ca 125 within the normal range. Ca 125 is not a diagnostic test. But is used to follow the progress of chemotherapy. ...Read more

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In stage 4 ovarian cancer, what does it usually mean if your ca-125 goes from 600 to 222 then back up to 350?

Some response: If therapies are changed we look at the ca125 levels to guide the choice of chemotherapy. This would be compatible with a temporary response to type of therapy. ...Read more

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How precise is the ca-125 test for ovarian cancer?

Other conditions too: Ca25 test can be positive in many conditions pregnancy endometriosis uterine fibroids pancreatitis liver disease normal menstruation other malignancies like lung, breast.Pacreas and GI tract cysts of the ovaries so here you have it it is not a specific test for ovarian cancer, thogh it may be positive as well. ...Read more

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How accurate is the ca-125 test for an ovarian cancer?

Not very.: Ca 125 is touted as a screening tool for ov ca but is elevated in only 50% of those with early stage disease. Approx 1% of normals have a high ca 125. Since ovarian cancer is relatively uncommon, the ability of a positive test to predict ca is about 3%. There is general consensus that ca 125 is not a good screening tool for average risk females. Consider ca 125 for those with high risk. ...Read more

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Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area. ...Read more

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Dr. Suzanne Galli
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Dr. John Geisler
234 doctors shared insights

Endometrial Cancer (Definition)

The endometrium is the lining of the inside of the uterus. Endometrial Cancer is cancer that starts in the cells of the endometrium and begins to spread to ...Read more