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Doctor insights on: First Sine Pregnancy

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On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree with my diagnosis of pd.?

On sinemet (carbidopa and levodopa) 2 times per day 62.5.  I want off this to try  other alternatives first  how do I safely do this.  I do not agree 
with my diagnosis of pd.?

See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read more

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Dr. Mark Pack
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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What is the typical starting dose for sinement for parkinson's?

What is the typical starting dose for sinement for parkinson's?

Small dose: In view of the reactions at the start (mostly gastrointestinal ) it is best to start with a very small dose e.g. Half a tablet of 25/100 and very gradually increase by increments on a daily basis even people tolerating much bigger dosages later should start slowly. ...Read more

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Have trouble getting up after DBS surgery for Parkinson’s. Could it be due to reduction in Sinement about 50% or has to do with suboptimal stimulation?

Have trouble getting up after DBS surgery for Parkinson’s. Could it be due to reduction in Sinement about 50% or has to do with suboptimal stimulation?

Need to talk: Directly to your movement specialist. This could be related to some many things from your reduction of Sinemet (carbidopa and levodopa) to some complication related to your DBS implantation. Don't get caught up spending too much time online, seek the input of your caregivers who know you best. Best of luck. ...Read more

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Parkinsons - Is it true that the bioequivalent dose of Sinement CR is 75-80% of the regular Sinemet (carbidopa and levodopa)?

Answer varies: The bioequivalent dose actually depends on the dose that is needed, your metabolism, what other medicines you use, an your experience with these medicines. The ratio of sinemet (carbidopa and levodopa) CR to regular sinemet (carbidopa and levodopa) may vary from 50% to 100% of the regular dose. Your number (75%) is right inbetween. For 600 mg regular sinemet (carbidopa and levodopa), most would start with 300 mg sinemet (carbidopa and levodopa) CR. ...Read more

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Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?

Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?

Different timing: CR is sustained release. Regular lasts only a few hours and tends to have more peaks and troughs. One can use both. Regular is given 3 to 4 times a day. ...Read more

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Please describe the medication: sinemet (carbidopa and levodopa)?

Please describe the medication: sinemet (carbidopa and levodopa)?

Carbidopa/levodopa: Sinemet (carbidopa and levodopa) is a combination drug that contains Carbidopa and levodopa. It is most commonly prescribed for parkinson's disease but may also be prescribed for other conditions including restless legs syndrome. ...Read more

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What is the typical dosage of sinemet (carbidopa and levodopa) cr?

What is the typical dosage of sinemet (carbidopa and levodopa) cr?

Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more

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What does sinemet (carbidopa and levodopa) consist of and what is cr?

What does sinemet (carbidopa and levodopa) consist of and what is cr?

See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read more

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I took 9 sinemet (carbidopa and levodopa) tablet a day, is that to much?

Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more

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What is the maximum dosage per day for Sinemet (carbidopa and levodopa) tablets?

What is the maximum dosage per day for Sinemet (carbidopa and levodopa) tablets?

Variable, but: In my experience, the maximum Sinemet (carbidopa and levodopa) dosing is the 25/250 tab four times daily, and if this seems to wear off, one can add Comtan (entacapone). Problem with going too high with L-DOPA is incidence of dyskinesias. ...Read more

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Is generic sinemet (carbidopa and levodopa) cr is not effective as the branded version?

Is generic sinemet (carbidopa and levodopa) cr is not effective as the branded version?

It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more

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Can I get levadopa without the carbidopa that's added in sinemet (carbidopa and levodopa)?

Not wise: The Carbidopa is there to prolong the effect of the L-DOPA, and without it the medication benefit will be very brief and needs to be taken several more times daily. ...Read more

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Which is more potent sinemet (carbidopa and levodopa) or the generic of carbidopa/levodopa?

Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more

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Milligrams for 6 hour sinemet (carbidopa and levodopa)? What is the dosage for this medication?

Milligrams for 6 hour sinemet (carbidopa and levodopa)? What is the dosage for this medication?

Dosages : Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more

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When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?

When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?

Not usually: You can usually use the same dose of Sinemet (carbidopa and levodopa) CR as you had of the regular Sinemet (carbidopa and levodopa). You may not feel it "kick in" as strongly but it should work just as effectively and hopefully last longer for you. Good luck. ...Read more

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What is the recommended taper schedule when discontinuing sinemet (carbidopa and levodopa)?

Slowly: Depends on dosing/schedule, but its very important to taper very slowly. It would be best to call your prescribing doctor and have them give you a clear tapering schedule. ...Read more

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How do you wean off sinemet (carbidopa and levodopa)?

Slow taper: If sinemet (carbidopa and levodopa) needs to be stopped, depending on the amount and indication for the medication, the most desire able way is to taper the medication. Parkinson's patients can have severe side effects if sinemet (carbidopa and levodopa) is abruptly stopped. ...Read more