Doctor insights on:
First Sine Pregnancy
On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree
with my diagnosis of pd.?
See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read moreSee 1 more doctor answer
When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more
I take Aricept (donepezil) 1o mg and sinement 100 mg. I want to know how is best taken. Like with or without food?
Small dose: In view of the reactions at the start (mostly gastrointestinal ) it is best to start with a very small dose e.g. Half a tablet of 25/100 and very gradually increase by increments on a daily basis even people tolerating much bigger dosages later should start slowly. ...Read moreSee 1 more doctor answer
Have trouble getting up after DBS surgery for Parkinson’s. Could it be due to reduction in Sinement about 50% or has to do with suboptimal stimulation?
Need to talk: Directly to your movement specialist. This could be related to some many things from your reduction of Sinemet (carbidopa and levodopa) to some complication related to your DBS implantation. Don't get caught up spending too much time online, seek the input of your caregivers who know you best. Best of luck. ...Read more
Parkinsons - Is it true that the bioequivalent dose of Sinement CR is 75-80% of the regular Sinemet (carbidopa and levodopa)?
Answer varies: The bioequivalent dose actually depends on the dose that is needed, your metabolism, what other medicines you use, an your experience with these medicines. The ratio of sinemet (carbidopa and levodopa) CR to regular sinemet (carbidopa and levodopa) may vary from 50% to 100% of the regular dose. Your number (75%) is right inbetween. For 600 mg regular sinemet (carbidopa and levodopa), most would start with 300 mg sinemet (carbidopa and levodopa) CR. ...Read more
Why is Sinemet (carbidopa and levodopa) CR is inferior to regular Sinement in terms of strength even though they carry the same mg in terms of dose for Parkinsons?
Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more
See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read moreSee 1 more doctor answer
Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more
Yes: But the GI side effects would make it intolerable. ...Read more
It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more
Dosages : Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more
When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?
Slowly: Depends on dosing/schedule, but its very important to taper very slowly. It would be best to call your prescribing doctor and have them give you a clear tapering schedule. ...Read more
Slow taper: If sinemet (carbidopa and levodopa) needs to be stopped, depending on the amount and indication for the medication, the most desire able way is to taper the medication. Parkinson's patients can have severe side effects if sinemet (carbidopa and levodopa) is abruptly stopped. ...Read more