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Doctor insights on: Fibrous Displasia

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How common are monostotic or polyostotic fibrous dysplasia?

How common are monostotic or polyostotic fibrous dysplasia?

Mono more common: Fibrous dysplasia nonheritable disease in which abnormal fibrous tissue develops in place of normal bone. Abnormalities may involve a single bone (monostotic form; 70% of cases) or many bones (polyostotic form; 30% of cases). Fibrous dysplasia represents five percent of bone tumors. ...Read more

Dr. Sanjiv Kaul
1 doctor shared a insight

Dysplasia (Definition)

Abnormal cells which may be pre-malignant, but can also result ...Read more


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Please interpret this tissue biopsy. Fibrous pericardium with granulation tissue and fibrinous exudate. There is mild fibroplasia?

Please interpret this tissue biopsy. Fibrous pericardium with granulation tissue and fibrinous exudate.  There is mild fibroplasia?

Healing: The pericardium has been injured in some way, perhaps by surgery or there may be a healing infection. What is means most of all is there isn't tumor. ...Read more

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Benign endocervical tissue showing immature squamous metaplasia, what is that?

Benign endocervical tissue showing immature squamous metaplasia, what is that?

ask yiour Gynecologi: The doctor who did the test can explain it better. But basically the test is looking for cancer cells which your report says you do not have at the present time. But continue to follow with annual pap tests so that this abnormalityy(minimal abnormality) resolves or gets monitored for any worsening. It is all a very slow process, not of any immediate concern but not always predictable. ...Read more

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What does this mean? Inverted papilloma with dysplasia and foci of in situ invasive squamous cell carcinoma (transitional)?

What does this mean? Inverted papilloma with dysplasia and foci of in situ invasive squamous cell carcinoma (transitional)?

Premalignant: An inverted papilloma is a tumor in which surface epithelial cells grow downward into the underlying supportive tissue. It may occur in the nose and/or sinuses or in the urinary tract (bladder, renal pelvis, ureter, urethra).. With dysplasia and in-situ squamous Ca this would probably be a premalignant sinus carcinoma bordering on squamous cell Ca needing resection. ...Read more

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Is fibromatosis a soft tissue sarcoma?

Is fibromatosis a soft tissue sarcoma?

Yes: Fibromatosis, while it doesn't have "sarcoma"in the name is actually a low-grade sarcoma. However, this only applies to cases occurring in the abdomen. Less commonly, these tumors can occur on the extremity. Cases of Palmar and Plantar fibromatosis are not aggressive and generally behave in a benign fashion. Have your sarcoma pathology checked by an expert david.stockman@orthopath.com ...Read more

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Superficial fragments of oesophagel mucosa lined by stratified squamous epithelium showing mild acanthosis and papillomatosis. Please explain?

Superficial  fragments of oesophagel mucosa lined by stratified squamous epithelium showing mild acanthosis and papillomatosis.  Please explain?

Fancy med talk: I just looked up in a medical dictionary: acanthosis means a thickening of a layer of the mucosa of the esophagus. This can be seen with chronic inflammation ( like with reflux disease). The word papillomatosis refers to papilla or projection of tissue sticking out. This can occur if there is chronic injury to the tissue and regeneration. Please ask your GI doctor to take the time to review this. ...Read more

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What is inverted papilloma with dysplasia and foci of in situto invasive squamous cell carcinoma(transitional)?

What is inverted papilloma with dysplasia and foci of in situto invasive squamous cell carcinoma(transitional)?

Location: What is the source of the biopsy? In the paranasal sinuses inverted papilloma is a sinus tumor traditionally treated with surgery, especially if there are foci of carcinoma. ...Read more

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Cyst with papillary excrescences is solid compact tissue?

Cyst with papillary excrescences is solid compact tissue?

No: A cyst is not solid. That's why it is called a cyst, because there is space inside which contains, or at some time had contained, material. ...Read more

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Breastduct excision fibrocystic changes,ductal hyperplasia w/o atypical,apocrine metaplasia,dilated benign ducts with thermal artifact.this means what?

Breastduct excision fibrocystic changes,ductal hyperplasia w/o atypical,apocrine metaplasia,dilated benign ducts with thermal artifact.this means what?

No cancer: All of the changes in your breast are benign and there is no cancer. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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What is focul intestinal metaplasia without displasia?

What is focul intestinal metaplasia without displasia?

A reactive change: "intestinal metaplasia" occurs when some other epithelial lining (like esophagus) is changed over time into intestinal epithelium- like found in the intestine. "focal" means this involves a limited area. "without dysplasia" means that although this intestinal epithelium is in the wrong place, it is healthy and not showing changes that are atypical or in danger of turning into a cancer. ...Read more

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Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?

Marker not prognosis: CK7 and calretinin are used to verify that the tumor is mesothelial in origin (versus adenocarcinoma of the lung). It does not provide information about prognosis. Factors associated with pleural mesothelioma prognosis include: functional status, blood counts, histology (epithelial best vs fibrosarcomatous poorest), and tumor size (degree of involvement of pleural cavity). Several new trials. ...Read more

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Could osteogenesis imperfecta affect the collagen within fibrous joints?

Could osteogenesis imperfecta affect the collagen within fibrous joints?

Osteogenenisis imper: OI affects or has to do with the collagen all over the body. Either too little or a variation in the structure of the collagen . These conditions are due to genes not coding for the correct or sufficient protein structure of the collagen. There are last count about 8 different subtypes of OI. So yes the collagen with in a fibrous joint can be affected as is the collagen in the body everywhere. ...Read more

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Diagnosis? Grade 2 chondromalacia, mucoid degeneration to acl, subchondral cyst tibial spines,soft tissue swelling in prepatellar- soft tissue lateral

Diagnosis? Grade 2 chondromalacia, mucoid degeneration to acl, subchondral cyst tibial spines,soft tissue swelling in prepatellar- soft tissue lateral

Diagnosis MRI?: Looks like a summary of an MRI Report. Grade 2 chondromalacia means you have some like age and activity related softening or wearing away of the articular cartilage in your knee. Age related changes to your ACL, but not a tear. Soft tissue swelling usually implies some swelling or bruising in the fat beneath your skin, but outside your joint ...Read more

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I was Diagnosed with Severe Dysplasia(CIN3)involving ectocervical squamous mucosa and fragments of benign endocervical glandular epithelium. ?

Cervical Cancer: CIN3 is a high risk precursor to cervical cancer and needs to be treated and followed up. Local procedures like LEEP or cone biopsy are important to exclude possible occult invasion. Follow-up following those with visual exam, pap and HPV testing to exclude recurrence or residual are vital. Visual exam to exclude HPV disease of vagina or vulva are also important. ...Read more

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CT scan shows "greater prominence of triangular soft tissue in anterior-superior mediastinum suggestive of reactive thymic tissue" Concerned?

CT scan shows "greater prominence of triangular soft tissue in anterior-superior mediastinum suggestive of reactive thymic tissue" Concerned?

May not be: The only concern would be if this a thymoma. This is something to evaluate by your physician. It can be associated with other medical problems and rarely can be malignant ...Read more

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Large detached squamous epithelium in bone marrow biopsy. What does that mean?

Large detached squamous epithelium in bone marrow biopsy. What does that mean?

Large chunk of skin: A chunk of skin must have been sent along with the bone fragment from the biopsy. Squamous epithelium is the skin cell type found in the outer layer of skin (& on contiguous surfaces like the inside of your mouth). It looks distinct under the microscope. In some cases, squamous cell cancer can invade the bone marrow, but I doubt that it is your case because the cells were detached, not mixed in. ...Read more

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Pathology report states: Postmenapausal Weakly-proliferative endometrium with focal glandular crowding. Focal mucinous metaplasia. Is this something t?

Pathology report states: Postmenapausal Weakly-proliferative endometrium with focal glandular crowding. Focal mucinous metaplasia. Is this something t?

Excess estrogen : This is suggestive of an increased estrogen state and maybe be a precursor to endometrial hyperplasia. alternatively it may be a component of a polyp. If you are in hormone supplements or tamoxifen you should consider stopping them. It warrants follow up with periodic re biopsy yo make sure nothing else is brewing. The good news is they didn't see any tumor. ...Read more

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Grade 2 invasive ductal carcinoma infiltrating as cords and tumour cells in a fibroadipose stroma, what does this mean?

Grade 2 invasive ductal carcinoma infiltrating as cords and tumour cells in a fibroadipose stroma, what does this mean?

Grade 2: There are 2 basic forms of breast cancer, ductal and lobular. Yours tumor is a ductal but it sounds like it has some lobular features, in particular it's infiltrating as cords sometimes called "Indian file infiltration". I don't think this has any clinical significance. See your oncologist and follow their advice. Most important is knowing lymph node status. Best of luck and God bless. ...Read more

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